Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Benfang Ruan"'
Autor:
Xiaoli Zhang, Wei Chen, Qiong Gao, Junsheng Yang, Xueni Yan, Han Zhao, Lin Su, Meimei Yang, Chenlang Gao, Yao Yao, Ken Inoki, Dan Li, Rong Shao, Shiyi Wang, Nirakar Sahoo, Fumitaka Kudo, Tadashi Eguchi, Benfang Ruan, Haoxing Xu
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000252 (2019)
Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a
Externí odkaz:
https://doaj.org/article/7572bdcdbb8b4629856919a744d68590
Autor:
Benfang Ruan, William K. Wilson, Jihai Pang, Nicolas Gerst, Frederick D. Pinkerton, James Tsai, Richard I. Kelley, Frank G. Whitby, Dianna M. Milewicz, James Garbern, George J. Schroepfer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 5, Pp 799-812 (2001)
Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol. Using rigorous analytical methods in
Externí odkaz:
https://doaj.org/article/7f841e5d40b7466db2e839c565d2650b
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 11, Pp 1772-1782 (2000)
Minor aberrant pathways of cholesterol biosynthesis normally produce only trace levels of abnormal sterol metabolites but may assume major importance when an essential biosynthetic step is blocked. Cholesta-5,8-dien-3β-ol, its Δ5,7 isomer, and othe
Externí odkaz:
https://doaj.org/article/ffc54446ec45413e856fe005cedc3171
Autor:
Benfang Ruan, Shinya Watanabe, John J. Eppig, Christopher Kwoh, Natasha Dzidic, Jihai Pang, William K. Wilson, George J. Schroepfer, Jr.
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 10, Pp 2005-2020 (1998)
4,4-Dimethyl-5α-cholesta-8,14,24-trien-3β-ol (I) from human follicular fluid and 4,4-dimethyl-5α-cholesta-8,24-dien-3β-ol (II) from bull testes have been reported to activate meiosis in mouse oocytes (Byskov et al., 1995. Nature. 374: 559–562).
Externí odkaz:
https://doaj.org/article/6e1289a21e394d7890b29866ce405844
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(11)
The rate of drug-induced proliferation (DIP) has been proposed as an unbiased alternative drug effect metric. However, current assays are not easy and precise enough to track minor changes in cell growth. Here, we report the optimized EZMTT based det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957b840f8075dfe6e2bd23a86329fdb9
https://pubmed.ncbi.nlm.nih.gov/32253062
https://pubmed.ncbi.nlm.nih.gov/32253062
Autor:
Benfang Ruan, Ning Xu
Publikováno v:
2018 9th International Conference on Information Technology in Medicine and Education (ITME).
The era of taking data as king is coming. How to relate big data to education reform and from whichapplication of study analysis derived, have gradually become hot research topics. This article took teacher educationMOOC training platform as example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222f7e59b169d7264f438d7eb4c7c55b
https://doi.org/10.1109/itme.2018.00159
https://doi.org/10.1109/itme.2018.00159
Autor:
Andrew R. Wood, Guy T. Carter, Edmund I. Graziani, Menelas N. Pangalos, Kevin Pong, Frank E. Koehn, Benfang Ruan, Ronald L. Magolda, Magid Abou-Gharbia, Robert A. Crozier, Flora Jow, Frann Bennett, Danni Liu, Mark R. Bowlby, Peter H. Reinhart, Xidong Feng, Mary Lynn T. Mercado, Leonard A. McDonald, Shi Liang, Yi Chen, Jerauld S. Skotnicki, Margaret M. Zaleska, David von Schack
Publikováno v:
Proceedings of the National Academy of Sciences. 105:33-38
Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c60bb03f86803494ea3efa91d69a376
https://doi.org/10.1073/pnas.0710424105
https://doi.org/10.1073/pnas.0710424105
Autor:
Meik Sacher, Christopher S. Francklyn, Constantinos Stathopoulos, Karl Poralla, Benfang Ruan, Dieter Söll, Michael L. Bovee
Publikováno v:
Journal of Biological Chemistry. 280:571-577
Borrelidin, a compound with anti-microbial and anti-angiogenic properties, is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). The inhibition mechanism of borrelidin is not well understood. Archaea contain archaeal and ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783528e7d481aeadcb13ce498321cfc8
https://doi.org/10.1074/jbc.m411039200
https://doi.org/10.1074/jbc.m411039200
Autor:
Ivan Ahel, Benfang Ruan, Anselm Sauerwald, Debra Tumbula-Hansen, D Kennedy, Dieter Söll, Alexandre Ambrogelly, Satwik Kamtekar
Publikováno v:
Cellular and Molecular Life Sciences. 61:2437-2445
Aminoacyl-tRNA ( transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd10d80b24357242fea8c5e0fb143a3
https://doi.org/10.1007/s00018-004-4194-9
https://doi.org/10.1007/s00018-004-4194-9
Autor:
Hiroaki Nakano, K. Brooks Low, John R. Battista, Bokkee Min, Joseph A. DeVito, Jonathan A. Mills, Benfang Ruan, Dieter Söll, Masashi Tanaka
Publikováno v:
Journal of Bacteriology. 186:8-14
Most organisms form Cys-tRNA Cys , an essential component for protein synthesis, through the action of cysteinyl-tRNA synthetase (CysRS). However, the genomes of Methanocaldococcus jannaschii , Methanothermobacter thermautotrophicus , and Methanopyru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14688e15835905baf489e8db919a013e
https://doi.org/10.1128/jb.186.1.8-14.2004
https://doi.org/10.1128/jb.186.1.8-14.2004