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Akademický článek

Slipped-strand mispairing within a polycytidine tract in transcriptional regulator mga leads to M protein phase variation and Mga length polymorphism in Group A Streptococcus

Autor: Benfang Lei, Tracey S. Hanks, Yunjuan Bao, Mengyao Liu

Publikováno v: Frontiers in Microbiology, Vol 14 (2023)

The M protein, a major virulence factor of Group A Streptococcus (GAS), is regulated by the multigene regulator Mga. An unexplained phenomena frequently occurring with in vitro genetic manipulation or culturing of M1T1 GAS strains is the loss of M pr

Externí odkaz: https://doaj.org/article/912ef860dd954de59bd431f274b3646e

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Akademický článek

Contemporary Pharyngeal and Invasive emm1 and Invasive emm12 Group A Streptococcus Isolates Exhibit Similar In Vivo Selection for CovRS Mutants in Mice.

Autor: Wenchao Feng, Mengyao Liu, Daniel G Chen, Rossana Yiu, Ferric C Fang, Benfang Lei

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0162742 (2016)

Group A Streptococcus (GAS) causes diverse infections ranging from common pharyngitis to rare severe invasive infections. Invasive GAS isolates can have natural mutations in the virulence regulator CovRS, which result in enhanced expression of multip

Externí odkaz: https://doaj.org/article/506eae42e2024c51a02e925d7ec23548

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Akademický článek

Serotype M3 and M28 Group A Streptococci Have Distinct Capacities to Evade Neutrophil and TNF-α Responses and to Invade Soft Tissues.

Autor: Zachary W Stetzner, Dengfeng Li, Wenchao Feng, Mengyao Liu, Guanghui Liu, James Wiley, Benfang Lei

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129417 (2015)

The M3 Serotype of Group A Streptococcus (GAS) is one of the three most frequent serotypes associated with severe invasive GAS infections, such as necrotizing fasciitis, in the United States and other industrialized countries. The basis for this asso

Externí odkaz: https://doaj.org/article/cc28a017e1804c2fa1783626c8c4c579

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Akademický článek

Non-heme-binding domains and segments of the Staphylococcus aureus IsdB protein critically contribute to the kinetics and equilibrium of heme acquisition from methemoglobin.

Autor: Hui Zhu, Dengfeng Li, Mengyao Liu, Valerie Copié, Benfang Lei

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100744 (2014)

The hemoglobin receptor IsdB rapidly acquires heme from methemoglobin (metHb) in the heme acquisition pathway of Staphylococcus aureus. IsdB consists of N-terminal segment (NS), NEAT1 (N1), middle (MD), and heme binding NEAT2 (N2) domains, and C-term

Externí odkaz: https://doaj.org/article/5a031e33503f4fbda41b7788e6f27cd3

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Akademický článek

Direct heme transfer reactions in the Group A Streptococcus heme acquisition pathway.

Autor: Chunmei Lu, Gang Xie, Mengyao Liu, Hui Zhu, Benfang Lei

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37556 (2012)

The heme acquisition machinery in Group A Streptococcus (GAS) consists of the surface proteins Shr and Shp and ATP-binding cassette transporter HtsABC. Shp cannot directly acquire heme from methemoglobin (metHb) but directly transfers its heme to Hts

Externí odkaz: https://doaj.org/article/32a35d0548f3462b8c312fea8276beb0

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Akademický článek

Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion.

Autor: Mengyao Liu, Hui Zhu, Jinquan Li, Cristiana C Garcia, Wenchao Feng, Liliya N Kirpotina, Jonathan Hilmer, Luciana P Tavares, Arthur W Layton, Mark T Quinn, Brian Bothner, Mauro M Teixeira, Benfang Lei

Publikováno v: PLoS Pathogens, Vol 8, Iss 4, p e1002624 (2012)

The innate immune system is the first line of host defense against invading organisms. Thus, pathogens have developed virulence mechanisms to evade the innate immune system. Here, we report a novel means for inhibition of neutrophil recruitment by Gr

Externí odkaz: https://doaj.org/article/76e8c2cf16ef4a73b8f2efef86117004

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Host-to-Host Group A Streptococcus Transmission Causes Infection of the Lamina Propria but Not Epithelium of the Upper Respiratory Tract in MyD88-Deficient Mice

Autor: Dylan Minor, Benfang Lei, Mark T. Quinn, Savannah Ontiveros, Thea Johnson, Jacob Cavon, Daniel Gao

Publikováno v: Infect Immun

To understand protective immune responses against the onset of group A Streptococcus respiratory infection, we investigated whether MyD88 KO mice were susceptible to acute infection through transmission. After commingling with mice that had intranasa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6111be0a57331da6282451f2000df0a
https://doi.org/10.1128/iai.00423-21

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Isolation of Neutrophils from Nonhuman Species

Autor: Daniel W, Siemsen, Liliya N, Kirpotina, Natalia, Malachowa, Igor A, Schepetkin, Adeline R, Porter, Benfang, Lei, Frank R, DeLeo, Mark T, Quinn

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2087

The development of new advances in understanding the role of neutrophils in inflammation requires effective procedures for isolating and purifying neutrophils. Methods for isolating human neutrophils are fairly standard, and some are covered in other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13f817b2eb41a9bfd4eb143bcea60405
https://pubmed.ncbi.nlm.nih.gov/31728982

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Isolation of Neutrophils from Nonhuman Species

Autor: Benfang Lei, Igor A. Schepetkin, Natalia Malachowa, Adeline R. Porter, Frank R. DeLeo, Mark T. Quinn, Daniel W. Siemsen, Liliya N. Kirpotina

Publikováno v: Methods in Molecular Biology ISBN: 9781071601532

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60db79a807edc195408865a2a820276e
https://doi.org/10.1007/978-1-0716-0154-9_4

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