Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability

Autor: Benelkebir, Hanae, Marie, Sabrina, Hayden, Annette L., Lyle, Jason, Loadman, Paul M., Crabb, Simon J., Packham, Graham, Ganesan, A.

Publikováno v: In Bioorganic & Medicinal Chemistry 2011 19(12):3650-3658

Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator

Autor: Silva,Anna C., Benelkebir,Hanae, Lopes,Rosangela S. C., Lopes,Claudio C., Ganesan,A.

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 29, Issue: 5, Pages: 1157-1161, Published: MAY 2018
Journal of the Brazilian Chemical Society v.29 n.5 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

The total synthesis of the plant natural product altissimacoumarin D was achieved by the Mitsunobu alkylation of isofraxidin by geraniol. Isofraxidin was prepared from 2,4-dihydroxybenzaldehyde in five steps. The key reaction was the Knoevenagel cond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e9ad5174cb2eaf3f537c393542cdf9bd
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000501157&lng=en&tlng=en

MOESM1 of LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

Autor: Mota, Sergio Regufe Da, Bailey, Sarah, Strivens, Rosemary, Hayden, Annette, Douglas, Leon, Duriez, Patrick, M. Borrello, Benelkebir, Hanae, A. Ganesan, Packham, Graham, Crabb, Simon

Additional file 1: FIgure S1. Figure S1 Molecular structure of the LSD1 inhibitors used in this work. Figure S2. In vitro LSD1 inhibition assay for the indicated compounds. Data points show percentage of LSD1 activity when compared with the DMSO trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63644a898d2f408147fc0ae91fe9263c

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