Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Benedito A, Carneiro"'
Autor:
Jennifer Li, Andy Yang, Benedito A. Carneiro, Ece D. Gamsiz Uzun, Lauren Massingham, Alper Uzun
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background The variant call format (VCF) file is a structured and comprehensive text file crucial for researchers and clinicians in interpreting and understanding genomic variation data. It contains essential information about variant positi
Externí odkaz:
https://doaj.org/article/6e7ebf4e867b46669d834b7c1dd326aa
Autor:
Dmitriy Zamarin, Diwakar Davar, Adel Samson, Kevin J Harrington, Siddharth Sheth, Eric Tu, Mitesh J Borad, Grace K Dy, Evanthia Galanis, Fernanda Arnaldez, Sandip P Patel, Nicholas Durham, Benedito A Carneiro, Sonia Agrawal, Zhongying Chen, Chunling Fan, Maozhen Gong, Jenny Burton, Kevin Laubscher
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background MEDI5395 is a recombinant attenuated Newcastle disease virus engineered to express a human granulocyte-macrophage colony-stimulating factor transgene. Preclinically, MEDI5395 demonstrated broad oncolytic activity, augmented by concomitant
Externí odkaz:
https://doaj.org/article/9b8ca43a8d514a34aab835d920738e15
Autor:
Jarushka Naidoo, Maria L Ascierto, Matthew D Hellmann, Ding Wang, Susana Banerjee, Mayukh Das, Panagiotis Kourtesis, Jennifer R Diamond, Teresa Alonso-Gordoa, Sandip P Patel, Nathan E Standifer, Doug C Palmer, Lin-Yang Cheng, Benedito A Carneiro
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background The combination of monalizumab (anti-NKG2A/CD94) and durvalumab (anti-programmed death ligand-1) may promote antitumor immunity by targeting innate and adaptive immunity. This phase 1/2 study of monalizumab and durvalumab evaluated safety,
Externí odkaz:
https://doaj.org/article/53d0d5cbaca340b3995a64a938291778
Autor:
Andrew Hsu, Kelsey E. Huntington, Andre De Souza, Lanlan Zhou, Adam J. Olszewski, Nirav P. Makwana, Diana O. Treaba, Ludimila Cavalcante, Francis J. Giles, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 417-423 (2022)
GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell functi
Externí odkaz:
https://doaj.org/article/92cb5ee1490243b8bd245afdd67c0799
Autor:
Cassandra Duarte, Junxiao Hu, Benoit Beuselinck, Justine Panian, Nicole Weise, Nazli Dizman, Katharine A. Collier, Nityam Rathi, Haoran Li, Roy Elias, Nieves Martinez-Chanza, Tracy L. Rose, Lauren C. Harshman, Dharmesh Gopalakrishnan, Ulka Vaishampayan, Yousef Zakharia, Vivek Narayan, Benedito A. Carneiro, Anthony Mega, Nirmish Singla, Cheryl Meguid, Saby George, James Brugarolas, Neeraj Agarwal, Amir Mortazavi, Sumanta Pal, Rana R. McKay, Elaine T. Lam
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 102018- (2023)
Summary: Background: Metastatic renal cell carcinoma (mRCC) is a heterogenous disease with poor 5-year overall survival (OS) at 14%. Patients with mRCC to endocrine organs historically have prolonged OS. Pancreatic metastases are uncommon overall, wi
Externí odkaz:
https://doaj.org/article/153c01ff313644d0bf2fd30f76560d5d
Autor:
Andrew George, Ilyas Sahin, Benedito A. Carneiro, Don S. Dizon, Howard P. Safran, Wafik S. El-Deiry
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 17, Iss 8, Pp 2595-2601 (2021)
Recent years have seen the emergence of immunotherapy as a promising modality for treating a variety of cancers. However, the initial data have led to the ultimate reality that such a treatment does not work effectively in all cancers, nor does it un
Externí odkaz:
https://doaj.org/article/8208f4199ace4aa7b266b3bc7d746d97
Autor:
Sourat Darabi, David R. Braxton, Joanne Xiu, Benedito A. Carneiro, Jeff Swensen, Emmanuel S. Antonarakis, Stephen V. Liu, Rana R. McKay, David Spetzler, Wafik S. El-Deiry, Michael J. Demeure
Publikováno v:
Medicina, Vol 58, Iss 12, p 1818 (2022)
Background: Reversion mutations in BRCA1/2, resulting in restoration of the open reading frame, have been identified as a mechanism of resistance to platinum-based chemotherapy or PARP inhibition. We sought to explore the incidence of BRCA1/2 reversi
Externí odkaz:
https://doaj.org/article/ba50c0656e284a5c8fe58a59c2af572c
Autor:
Antonio V. Alves da Silva, Francisco Martins Neto, Ana Claudia da Silva M. de Oliveira, Benedito A. Carneiro, Marclesson Alves, Cleto Dantas Nogueira, Fabio Tavora
Publikováno v:
Surgical and Experimental Pathology, Vol 2, Iss 1, Pp 1-6 (2019)
Abstract Background As Immune checkpoint inhibitors (ICPIs) are changing the standard-care in lung cancer with good clinical activities and durable responses, its indication must be based on the appropriate patient selection once only a fraction of p
Externí odkaz:
https://doaj.org/article/ea429c559c52457788981f1f15eb99fa
Autor:
Justin Hwang, Xiaolei Shi, Andrew Elliott, Taylor E. Arnoff, Julie McGrath, Joanne Xiu, Phillip Walker, Hannah E. Bergom, Abderrahman Day, Shihab Ahmed, Sydney Tape, Allison Makovec, Atef Ali, Rami M. Shaker, Eamon Toye, Rachel Passow, John R. Lozada, Jinhua Wang, Emil Lou, Kent W. Mouw, Benedito A. Carneiro, Elisabeth I. Heath, Rana R. McKay, W. Michael Korn, Chadi Nabhan, Charles J. Ryan, Emmanuel S. Antonarakis
Publikováno v:
Clinical Cancer Research. :OF1-OF12
Purpose: In patients with metastatic prostate cancer (mPC), ATM and BRCA2 mutations dictate differences in PARPi inhibitor response and other therapies. We interrogated the molecular features of ATM- and BRCA2-mutated mPC to explain the divergent cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d167d2d8a4d064f76b84d6fc7c1b06cd
https://doi.org/10.1158/1078-0432.ccr-22-3394
https://doi.org/10.1158/1078-0432.ccr-22-3394
Autor:
Stephen K. Tahir, Emiliano Calvo, Benedito A. Carneiro, Junichiro Yuda, Aditya Shreenivas, Mojca Jongen-Lavrencic, Eelke Gort, Kenichi Ishizawa, Daniel Morillo, Carla Biesdorf, Morey Smith, Dong Cheng, Monica Motwani, David Sharon, Tamar Uziel, Dimple A. Modi, Fritz G. Buchanan, Susan Morgan-Lappe, Bruno C. Medeiros, Darren C. Phillips
Publikováno v:
Blood, 141(17), 2114-2126. American Society of Hematology
Activation of apoptosis in malignant cells is an established strategy for controlling cancer and is potentially curative. To assess the impact of concurrently inducing the extrinsic and intrinsic apoptosis-signaling pathways in acute myeloid leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298281c9a9769a2760e6484a88646b4
https://doi.org/10.1182/blood.2022017333
https://doi.org/10.1182/blood.2022017333