Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Benedikt Wanner"'
Publikováno v:
CHIMIA, Vol 74, Iss 10, Pp 808-813 (2020)
Despite recent advances in reaction methodologies, organic synthesis remains complex and challenging. Many of the fundamental processes in use have not changed in over 100 years, with a large proportion of the work being carried out manually, using l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d135c4a8252fa7939864c875045f61d
https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000010/art00015
https://www.ingentaconnect.com/contentone/scs/chimia/2020/00000074/00000010/art00015
Autor:
Paula L. Nichols, Kuang-Yen Chen, Jeffrey W. Bode, Angus McMillan, Tuo Jiang, Fumito Saito, Benedikt Wanner, Samuele Bordi
Publikováno v:
Chemical Science, 12 (20)
Chemical Science
Chemical Science
The current laboratory practices of organic synthesis are labor intensive, impose safety and environmental hazards, and hamper the implementation of artificial intelligence guided drug discovery. Using a combination of reagent design, hardware engine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4275bf3fa4b8d5fd537cce568668ab12
https://hdl.handle.net/20.500.11850/488670
https://hdl.handle.net/20.500.11850/488670
Autor:
Tuo Jiang, Samuele Bordi, Angus E. McMillan, Kuang-Yen Chen, Fumito Saito, Paula Nichols, Benedikt Wanner, Jeffrey Bode
The current laboratory-based practice of organic synthesis renders automation difficult, suffers from safety and environmental hazards, and hampers the implementation of artificial intelligence guided drug discovery. Using a combination of innovative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae5696b7824a1a9b4d242dce99202fc
https://doi.org/10.26434/chemrxiv.7882799
https://doi.org/10.26434/chemrxiv.7882799
Publikováno v:
Angewandte Chemie (International ed. in English)
Nonribosomal peptide synthetases (NRPSs) are multifunctional enzymes that produce a wide array of bioactive peptides. Here we show that a single tryptophan-to-serine mutation in phenylalanine-specific NRPS adenylation domains enables the efficient ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240bca54031d878a20cd9bc626c8c01d
https://doi.org/10.1002/anie.201405281
https://doi.org/10.1002/anie.201405281
Autor:
Benedikt Wanner, Jeffrey W. Bode, Philip Wheeler, Sheng-Ying Hsieh, André M. Beauchemin, Tomislav Rovis
Publikováno v:
Chemistry-A European Journal, 20 (24)
The kinetic resolution of N-heterocycles with chiral acylating agents reveals a previously unrecognized stereoelectronic effect in amine acylation. Combined with a new achiral hydroxamate, this effect makes possible the resolution of various N-hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd996704e15a7cf464aff9dbd8845ac
https://doi.org/10.1002/chem.201402818
https://doi.org/10.1002/chem.201402818
Publikováno v:
ChemInform. 47
The catalytic kinetic resolution of cyclic amines with achiral N-heterocyclic carbenes and chiral hydroxamic acids has emerged as a promising method to obtain enantio-enriched amines with high selectivity factors. In this report, we describe the cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b200c6b37b15e810b11f80768123159
https://doi.org/10.1002/chin.201605021
https://doi.org/10.1002/chin.201605021
Publikováno v:
Journal of the American Chemical Society, 137 (35)
Journal of the American Chemical Society, 137 (35)
ISSN:0002-7863
ISSN:1520-5126
ISSN:0002-7863
ISSN:1520-5126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93275897f826be97119e5ec4dcf3d784
https://hdl.handle.net/20.500.11850/260482
https://hdl.handle.net/20.500.11850/260482
Autor:
André M. Beauchemin, Tomislav Rovis, Philip Wheeler, Jeffrey W. Bode, Benedikt Wanner, Sheng-Ying Hsieh
Publikováno v:
ChemInform. 45
A novel chiral acyl hydroxamate reagent is developed and its application to the kinetic resolution of N-heterocycles is demonstrated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23391a595a50bc7fdd0f45637008637
https://doi.org/10.1002/chin.201450146
https://doi.org/10.1002/chin.201450146
Publikováno v:
ChemInform. 43
N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their α′-hydroxyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdaeeab6cdfa4c7e8d825808858a1baf
https://doi.org/10.1002/chin.201205169
https://doi.org/10.1002/chin.201205169
Publikováno v:
Organic letters. 13(19)
N-Heterocyclic carbene catalyzed aza-Claisen annulations of enals or their α′-hydroxyenone surrogates with vinylogous amides afford dihydropyridinones. The reaction proceeds with a broad range of substrates, and no nitrogen protecting group is req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064e250fe6e7df4dfab17407475c89c4
https://pubmed.ncbi.nlm.nih.gov/21905682
https://pubmed.ncbi.nlm.nih.gov/21905682