Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benedikt S. Nilges"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Ribosome profiling has become the gold standard to analyze mRNA translation dynamics, and the translation inhibitor cycloheximide (CHX) is often used in its application. Here the authors systematically demonstrate that CHX does not bias the outcome o
Externí odkaz:
https://doaj.org/article/6fc16742fd5346298a852f3763b9b39b
Autor:
Percival P. D’Gama, Tao Qiu, Mehmet Ilyas Cosacak, Dheeraj Rayamajhi, Ahsen Konac, Jan Niklas Hansen, Christa Ringers, Francisca Acuña-Hinrichsen, Subhra P. Hui, Emilie W. Olstad, Yan Ling Chong, Charlton Kang An Lim, Astha Gupta, Chee Peng Ng, Benedikt S. Nilges, Nachiket D. Kashikar, Dagmar Wachten, David Liebl, Kazu Kikuchi, Caghan Kizil, Emre Yaksi, Sudipto Roy, Nathalie Jurisch-Yaksi
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109775- (2021)
Summary: Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We
Externí odkaz:
https://doaj.org/article/1dd717feda074446b65e421f9b70e01f
Autor:
Magnus E. Jakobsson, Jędrzej M. Małecki, Levon Halabelian, Benedikt S. Nilges, Rita Pinto, Srikanth Kudithipudi, Stephanie Munk, Erna Davydova, Fawzi R. Zuhairi, Cheryl H. Arrowsmith, Albert Jeltsch, Sebastian A. Leidel, Jesper V. Olsen, Pål Ø. Falnes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Eukaryotic elongation factor 1 alpha (eEF1A) is subject to extensive post-translational methylation but not all responsible enzymes are known. Here, the authors identify METTL13 as an eEF1A methyltransferase with dual specificity, which is involved i
Externí odkaz:
https://doaj.org/article/1682b8aad27f487895096c47624bca86
Autor:
Andreas Geipel, Frank Reinecke, Silvia Groiss, Melina Hardt, Benedikt S. Nilges, Conny Unger, Daniela Pabst, Sascha Strauss, Annette Bogdoll, Christian Korfhage, Andreas Meier, Kurt Zatloukal, Cynthia Faber, Esther Foederl-Hoebenreich
Single-cell spatial transcriptomics technologies leveraged the potential to transcriptionally landscape sophisticated reactions in cells. Current methods to delineate such complex interplay lack the flexibility in rapid target adaptation and are part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d177a94a06e776d3fcd98803f626e4a6
https://doi.org/10.1101/2021.10.11.463936
https://doi.org/10.1101/2021.10.11.463936
Autor:
Caghan Kizil, Sudipto Roy, Nachiket D. Kashikar, David Liebl, Kazu Kikuchi, Dagmar Wachten, Emre Yaksi, Mehmet Ilyas Cosacak, Benedikt S. Nilges, Christa Ringers, Astha Gupta, Francisca Acuña-Hinrichsen, Nathalie Jurisch-Yaksi, Ahsen Konac, Dheeraj Rayamajhi, Charlton Kang An Lim, Subhra Prakash Hui, Percival P. D’Gama, Jan N. Hansen, Yan Ling Chong, Chee Peng Ng, Tao Qiu, Emilie W. Olstad
Publikováno v:
Cell reports 37(1), 109775 (2021). doi:10.1016/j.celrep.2021.109775
Cell Reports, Vol 37, Iss 1, Pp 109775-(2021)
Cell reports
Cell Reports
Cell Reports, Vol 37, Iss 1, Pp 109775-(2021)
Cell reports
Cell Reports
Summary Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1fd9d411a42424d116a6de37aaa405
https://pub.dzne.de/record/162905
https://pub.dzne.de/record/162905
Autor:
Katja Hartstock, Ann‐Marie Lawrence‐Dörner, Sebastian A. Leidel, Andrea Rentmeister, Nikolai Püllen, Nicolas V. Cornelissen, Anna Ovcharenko, Benedikt S. Nilges
Publikováno v:
Angewandte Chemie. 130:6451-6455
Autor:
Nicolas V. Cornelissen, Benedikt S. Nilges, Sebastian A. Leidel, Nikolai Püllen, Andrea Rentmeister, Katja Hartstock, Ann‐Marie Lawrence‐Dörner, Anna Ovcharenko
Publikováno v:
Angewandte Chemie International Edition. 57:6342-6346
m6 A is the most abundant internal modification in eukaryotic mRNA. It is introduced by METTL3-METTL14 and tunes mRNA metabolism, impacting cell differentiation and development. Precise transcriptome-wide assignment of m6 A sites is of utmost importa
Autor:
Pål Ø. Falnes, Benedikt S. Nilges, Jędrzej Małecki, Anders Moen, Magnus E. Jakobsson, Sebastian A. Leidel
Publikováno v:
Nucleic Acids Research
Many cellular proteins are methylated on lysine residues and this has been most intensively studied for histone proteins. Lysine methylations on non-histone proteins are also frequent, but in most cases the functional significance of the methylation
The translation inhibitor cycloheximide affects ribosome profiling data in a species-specific manner
Ribosome profiling provides genome-wide snapshots of translation dynamics by determining ribosomal positions at sub-codon resolution. To maintain this positional information, the translation inhibitor cycloheximide (CHX) has been widely used to arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a3a1307b8a1147214a0356f7c83a4c
https://doi.org/10.1101/746255
https://doi.org/10.1101/746255
Autor:
Sebastian A. Leidel, Juliane P. Schwarz, Puneet Sharma, Aarón Lecanda, Danny D. Nedialkova, Juan M. Vaquerizas, Benedikt S. Nilges
Publikováno v:
Methods (San Diego, Calif.)
Protein translation is at the heart of cellular metabolism and its in-depth characterization is key for many lines of research. Recently, ribosome profiling became the state-of-the-art method to quantitatively characterize translation dynamics at a t