Genetic Evidence Reveals the Indispensable Role of the rseC Gene for Autotrophy and the Importance of a Functional Electron Balance for Nitrate Reduction in Clostridium ljungdahlii

Autor: Christian-Marco Klask, Benedikt Jäger, Isabella Casini, Largus T. Angenent, Bastian Molitor

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

For Clostridium ljungdahlii, the RNF complex plays a key role for energy conversion from gaseous substrates such as hydrogen and carbon dioxide. In a previous study, a disruption of RNF-complex genes led to the loss of autotrophy, while heterotrophy

Externí odkaz: https://doaj.org/article/b61cfd35f7c04172a8d5d6c1827554ae

Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis.

Autor: Jonas Christian Schupp, Harald Binder, Benedikt Jäger, Giuseppe Cillis, Gernot Zissel, Joachim Müller-Quernheim, Antje Prasse

Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0116775 (2015)

BACKGROUND:Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a common cause of disease acceleration in IPF and has a major impact on mortality. The role of macrophage activation in AE of IPF has never been addressed before. METHODS:We

Externí odkaz: https://doaj.org/article/50be1b63f020418ba27ad65c680c2633

The NLRP3-inflammasome-caspase-1 pathway is upregulated in idiopathic pulmonary fibrosis and acute exacerbations and is inducible by apoptotic A549 cells

Autor: Oliver Terwolbeck, Tobias Welte, Christian Bode, Benjamin Seeliger, Antje Prasse, Benedikt Jäger

Publikováno v: Mechanisms of lung injury and repair.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7647cb98097ecabb8fca6f268266a383
https://doi.org/10.1183/13993003.congress-2021.oa2697

CXCR4/MIF axis amplifies tumor growth and epithelial-mesenchymal interaction in non-small cell lung cancer

Autor: Axel Schambach, Denise Klatt, Philippe Dänzer Barbosa, Benedikt Jäger, Antje Prasse, Stefan Lienenklaus, Heiko Golpon, Linda Plappert

Publikováno v: Cellular signalling. 73

Overexpression of C-X-C chemokine receptor type 4 (CXCR4) has been shown in several cancers, including non-small cell lung cancer (NSCLC) and is linked to early metastasis and worse prognosis. The crosstalk between cancer cells and tumor stroma promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6264eb0262e137c0dcaebd27f843628
https://pubmed.ncbi.nlm.nih.gov/32428553

Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung

Autor: Torsten Goldmann, Mathias Gugger, Thomas Geiser, Anis Feki, Luca Tamò, Cedric Simillion, Benedikt Jäger, Antje Prasse, Youssef Hibaoui, Amiq Gazdhar

Publikováno v: Tamò, Luca Giuseppe Athos; Simillion, Cedric; Hibaoui, Youssef; Feki, Anis; Gugger, Mathias; Prasse, Antje; Jäger, Benedikt; Goldmann, Torsten; Geiser, Thomas; Gazdhar, Amiq (2018). Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung. Stem cell reviews and reports, 14(3), pp. 412-424. Springer 10.1007/s12015-017-9790-9
Stem Cell Reviews

Idiopathic pulmonary fibrosis (IPF) is a complex disease involving various cell types. Macrophages are essential in maintenance of physiological homeostasis, wound repair and fibrosis in the lung. Macrophages play a crucial role in repair and remodel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bab0c8d896e40ef4304d931ea94b34
https://doi.org/10.1007/s12015-017-9790-9