Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Benedikt Brommer"'
Autor:
Benedikt Brommer, Miao He, Zicong Zhang, Zhiyun Yang, Jessica C. Page, Junfeng Su, Yu Zhang, Junjie Zhu, Emilia Gouy, Jing Tang, Philip Williams, Wei Dai, Qi Wang, Ryan Solinsky, Bo Chen, Zhigang He
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
After complete spinal cord injury, spinal segments below the lesion maintain inter-segmental communication via the intraspinal propriospinal network. Here, the authors show that neurons in these circuits can be chemogenetically modulated to improve l
Externí odkaz:
https://doaj.org/article/0b0fd2c9e2db49508b02ef527b81b2d1
Autor:
Jessica C. Page, Yu Zhang, Emilia Gouy, Philip R. Williams, Qi Wang, Wei Dai, Miao He, Zicong Zhang, Zhiyun Yang, Bo Chen, Benedikt Brommer, Junfeng Su, Jing Tang, Zhigang He, Ryan Solinsky, Junjie Zhu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
After complete spinal cord injuries (SCI), spinal segments below the lesion maintain inter-segmental communication via the intraspinal propriospinal network. However, it is unknown whether selective manipulation of these circuits can restore locomoto
Autor:
Bruce R. Ksander, Morgan E. Levine, Emma Hoffmann, Luis A. Rajman, Zhigang He, Meredith S Gregory-Ksander, Michael Bonkowski, Anitha Krishnan, Jae-Hyun Yang, Chen Wang, Alice E. Kane, Ekaterina Korobkina, Songlin Zhou, Xiao Tian, Margarita Meer, George M. Church, Yu D, Michael B. Schultz, Karolina Chwalek, Noah Davidsohn, Steve Horvath, Yuancheng Lu, Qiurui Zeng, Konrad Hochedlinger, David A. Sinclair, Daniel L. Vera, Vadim N. Gladyshev, Margarete M. Karg, Benedikt Brommer
Publikováno v:
Nature
Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity1
Autor:
Ralf Watzlawick, Julian Rind, Emily S Sena, Benedikt Brommer, Tian Zhang, Marcel A Kopp, Ulrich Dirnagl, Malcolm R Macleod, David W Howells, Jan M Schwab
Publikováno v:
PLoS Biology, Vol 14, Iss 5, p e1002468 (2016)
Olfactory ensheathing cell (OEC) transplantation is a candidate cellular treatment approach for human spinal cord injury (SCI) due to their unique regenerative potential and autologous origin. The objective of this study was, through a meta-epidemiol
Externí odkaz:
https://doaj.org/article/a5bdbd026fe74a8a85e368598cb2d8ff
Autor:
Agnieszka Münster-Wandowski, Astrid Rohrbeck, Jan M. Schwab, Hans-Georg Kuhn, Markus Höltje, Andrej Adolf, Benedikt Brommer, Gudrun Ahnert-Hilger, Ingo Just, Malin Johansson, Marcel A. Kopp
Publikováno v:
Glia. 67:703-717
Clostridium botulinum C3 transferase (C3bot) ADP-ribosylates rho proteins to change cellular functions in a variety of cell types including astrocytes and neurons. The intermediate filament protein vimentin as well as transmembrane integrins are invo
Autor:
Harald Prüss, Berit Rosche, Aaron B Sullivan, Benedikt Brommer, Oliver Wengert, Karsten Gronert, Jan M Schwab
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55859 (2013)
The severity and longevity of inflammation is controlled by endogenous counter-regulatory signals. Among them are long-chain polyunsaturated fatty acid (PUFA)-derived lipid mediators, which promote the resolution of inflammation, an active process fo
Externí odkaz:
https://doaj.org/article/483a136db1304ee6afdb15e292aadde3
Autor:
Jan M. Schwab, Eva Santos-Nogueira, Rubèn López-Vales, Aaron B. Sullivan, Benedikt Brommer, Marcel A. Kopp, Karsten Gronert, Isaac Francos-Quijorna, Samuel David
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Universitat Autònoma de Barcelona
Resolution of inflammation is defective after spinal cord injury (SCI), which impairs tissue integrity and remodeling and leads to functional deficits. Effective pharmacological treatments for SCI are not currently available. Maresin 1 (MaR1) is a hi
Autor:
David A. Sinclair, Benedikt Brommer, Michael Bonkowski, Anitha Krishnan, Konrad Hochedlinger, Margarita Meer, Yu D, Bruce R. Ksander, James Chih-Hsin Yang, Noah Davidsohn, Karolina Chwalek, Shao-Ming Zhou, Yuancheng Lu, Qiurui Zeng, Daniel L. Vera, Vadim N. Gladyshev, Michael B. Schultz, Steve Horvath, Xiao Tian, George M. Church, Emma Hoffmann, Chen Wang, Luis A. Rajman, Meredith S Gregory-Ksander, Ekaterina Korobkina, Zhigang He
Ageing is a degenerative process leading to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise, which disrupts youthful gene expression patterns that are required for cells to function optimally and recov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1aa13f06cd1ee4d4508a57d3d466f9d
https://doi.org/10.1101/710210
https://doi.org/10.1101/710210
Autor:
Yi Ping Zhang, Wei Huang, Lisa B E Shields, Guofeng Yan, Benedikt Brommer, Melissa J. Walker, Kemin Chen, Zhengwen Ma, Yao Li, Christopher B. Shields, Wei Liu, Xiao Ming Xu, Yi Lu, Xuejin Chen, Maiying Kong
Publikováno v:
Experimental Neurology. 279:261-273
Most in vivo spinal cord injury (SCI) experimental models use rodents. Due to the anatomical and functional differences between rodents and humans, reliable large animal models, such as non-human primates, of SCI are critically needed to facilitate t
Autor:
Benedikt Brommer, Zhigang He, Luis Bonet-Ponce, Chen Wang, Christo Kole, Mohor Sengupta, Naoki Nakaya, Stanislav I. Tomarev, Wei Li, Tantai Zhao
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To investigate the possible role of activating transcription factor 3 (ATF3) in retinal ganglion cell (RGC) neuroprotection and optic nerve regeneration after optic nerve crush (ONC). Methods Overexpression of proteins of interest (ATF3, phos