Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Benedikt B. Kaufer"'
Autor:
Yu You, Ahmed M. Kheimar, Tereza Vychodil, Lisa Kossak, Mohammad A. Sabsabi, Andelé M. Conradie, Sanjay M. Reddy, Luca D. Bertzbach, Benedikt B. Kaufer
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-8 (2024)
Abstract Marek’s disease virus (MDV) integrates its genome into the telomeres of host chromosomes and causes fatal lymphomas in chickens. This integration is facilitated by telomeric repeat sequences (TMRs) at the ends of the viral genome, and is c
Externí odkaz:
https://doaj.org/article/dbb9de82470d45bb8b74af901a62836e
Autor:
Mohammad A. Sabsabi, Ahmed Kheimar, Yu You, Dominik von La Roche, Sonja Härtle, Thomas W. Göbel, Theresa von Heyl, Benjamin Schusser, Benedikt B. Kaufer
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that causes deadly lymphomas in chickens. In chickens, up to 50% of all peripheral T cells are gamma delta (γδ) T cells. Until now, their role in MDV pathogenesis and tumor for
Externí odkaz:
https://doaj.org/article/0c96e4576b904e06a16d362eecd77b83
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cell receptor (TCR) repertoire sequencing has emerged as a powerful tool for understanding the diversity and functionality of T cells within the host immune system. Yet, the chicken TCR repertoire remains poorly understood due to incomplete genome
Externí odkaz:
https://doaj.org/article/20fe5ed6d96c48a8af86d05b829b1605
Autor:
Ahmed Kheimar, Laetitia Trapp-Fragnet, Andelé M. Conradie, Luca D. Bertzbach, Yu You, Mohammad A. Sabsabi, Benedikt B. Kaufer
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Human telomerase RNA (hTR) is overexpressed in many cancers and protects T cells from apoptosis in a telomerase-independent manner. The most prevalent cancer in the animal kingdom is caused by the highly oncogenic herpesvirus Marek’s disea
Externí odkaz:
https://doaj.org/article/acaf75580841497ba8661c2605be03eb
Autor:
Luca D. Bertzbach, Marina Kohn, Yu You, Lisa Kossak, Mohammad A. Sabsabi, Ahmed Kheimar, Sonja Härtle, Benedikt B. Kaufer
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102343- (2023)
Summary: Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that infects immune cells and causes a deadly lymphoproliferative disease in chickens. Cytokines and monoclonal antibodies promote the survival of chicken lymphocytes in vi
Externí odkaz:
https://doaj.org/article/6b80953abc8044f2bb0169e3344fbe22
Autor:
DongHoon Yu, Sabrina Wagner, Martin Schütz, Yeejin Jeon, Mooyoung Seo, Jaeseung Kim, Nadine Brückner, Jintawee Kicuntod, Julia Tillmanns, Christina Wangen, Friedrich Hahn, Benedikt B. Kaufer, Frank Neipel, Jan Eickhoff, Bert Klebl, Kiyean Nam, Manfred Marschall
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 158 (2024)
The repertoire of currently available antiviral drugs spans therapeutic applications against a number of important human pathogens distributed worldwide. These include cases of the pandemic severe acute respiratory coronavirus type 2 (SARS-CoV-2 or C
Externí odkaz:
https://doaj.org/article/bc65e804ec3a43f1ab41539356429fa9
Autor:
Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B. Kaufer, Peter H. Seeberger
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-7 (2021)
Abstract Background Traditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Tea
Externí odkaz:
https://doaj.org/article/08f0993f1b6c476ab4fae874f97b0cab
Autor:
Luca D. Bertzbach, Clive A. Tregaskes, Rebecca J. Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M. Kheimar, Andelé M. Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B. Kaufer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens. Chickens possess a single predominantly-expressed class I molecule with strong associations between disease resistance and MHC haplotyp
Externí odkaz:
https://doaj.org/article/4095716551bc420a801d0a73a8cb8715
Publikováno v:
Microorganisms, Vol 11, Iss 3, p 805 (2023)
Marek’s disease virus (MDV), an Alphaherpesvirus belonging to the genus Mardivirus, causes T cell lymphomas in chickens and remains one of the greatest threats to poultry production worldwide [...]
Externí odkaz:
https://doaj.org/article/df9796038db74e488e3e63a87bd9c8bc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Marek’s disease virus (MDV), an avian alphaherpesvirus, infects chickens, transforms CD4+ T cells, and induces immunosuppression early during infection. However, the exact mechanisms involved in MDV-induced immunosuppression are yet to be identifie
Externí odkaz:
https://doaj.org/article/8ef9b155eae1450fb46c81651de219ee