Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Benedikt, Kaufmann"'
Hepatocellular Brg1 promotes CCl4-induced liver inflammation, ECM accumulation and fibrosis in mice.
Autor:
Baocai Wang, Benedikt Kaufmann, Carolin Mogler, Suyang Zhong, Yuhan Yin, Zhangjun Cheng, Roland M Schmid, Helmut Friess, Norbert Hüser, Guido von Figura, Daniel Hartmann
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294257 (2023)
IntroductionHepatic fibrosis is a progressive pathological process involving the exhaustion of hepatocellular regenerative capacity and ultimately leading to the development of cirrhosis and even hepatocellular carcinoma. Brg1, the core subunit of th
Externí odkaz:
https://doaj.org/article/888e4bdaf26d4e89930db833f3af5847
Autor:
Andrea D. Kim, Sung Eun Kim, Aleksandra Leszczynska, Benedikt Kaufmann, Agustina Reca, Dong Joon Kim, Ariel E. Feldstein
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Inflammatory changes in the liver represent a key feature of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD). Innate immune activation including hepatic neutrophilic infiltration acts a
Externí odkaz:
https://doaj.org/article/fed38ca200d94965a77ccb3131e9ccc6
Autor:
Ulrich Nitsche, Constance Weber, Benedikt Kaufmann, Guido von Figura, Volker Assfalg, Gregor Miller, Helmut Friess, Norbert Hüser, Daniel Hartmann
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105973- (2020)
Between 2007 and 2016, 140 consecutive patients who underwent resection of colorectal cancer with simultaneous liver metastases at a single university hospital were retrospectively analysed. In order to gather information regarding potential survival
Externí odkaz:
https://doaj.org/article/172348f2ee6449eaa0f781d2a1760728
Autor:
Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M. Booshehri, Janset Onyuru, Aleksandra Leszczynska, Anna Uri, Sven Michel, Richard Klar, Frank Jaschinski, Ariel E. Feldstein, Lori Broderick, Hal M. Hoffman
Publikováno v:
The Journal of Immunology.
Antisense oligonucleotides (ASOs) are a novel therapeutic strategy that targets a specific gene and suppresses its expression. The cryopyrin-associated periodic syndromes (CAPS) are a spectrum of autoinflammatory diseases characterized by systemic an
Autor:
Andrea D. Kim, Lin Kui, Benedikt Kaufmann, Sung Eun Kim, Aleksandra Leszczynska, Ariel E. Feldstein
Publikováno v:
Journal of Molecular Medicine.
Abstract Chitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic liver diseases including non-alcoholic steatohepatitis (NASH). However, the mechanisms by which CHI3L1 contributes to fibro
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology.
The use of probiotics, prebiotics and synbiotics has become an important therapy in numerous gastrointestinal diseases in recent years. Modifying the gut microbiota, this therapeutic approach helps to restore a healthy microbiome. Nonalcoholic fatty
Autor:
Antonio Abbate, Ivona Aksentijevich, Marcelo Pires Amaral, Magaiver Andrade-Silva, Diego Angosto-Bazarra, Luca Antonioli, Kübra Aral, Juan I. Aróstegui, Jillian Barlow, Laura Benvenuti, Nunzia Bernardini, Massimo Bertinaria, Monika Biasizzo, Karina Ramalho Bortoluci, Dave Boucher, Laura Migliari Branco, David Brough, Petr Broz, Clare E. Bryant, Mark Cahill, Matthew Campbell, Soo Jung Cho, Shelbi Christgen, Rebecca C. Coll, Isabelle Couillin, Brianna Cyr, Sarah Dalmon, Juan Pablo de Rivero Vaccari, Francesco Di Virgilio, Andrea Dorfleutner, Sarah L. Doyle, Vanessa D'Antongiovanni, Ariel E. Feldstein, Matteo Fornai, Carlos García-Palenciano, Simone Gastaldi, Matthias Geyer, François Ghiringhelli, Anna Lisa Giuliani, José Manuel González-Navajas, Iva Hafner-Bratkovič, Shaima'a Hamarsheh, Michael T. Heneka, Thomas Henry, Jun-ichi Hikima, Inga V. Hochheiser, Alexander Hogg, Alexander Hooftman, Christopher Hoyle, Yin Huang, Sarah Huot-Marchand, Laura Hurtado-Navarro, Sushmita Jha, Thirumala-Devi Kanneganti, Benedikt Kaufmann, Andrea D. Kim, Nataša Kopitar-Jerala, Jordana Kron, Silvia Lucena Lage, Beatriz Lozano-Ruiz, Elisabetta Marini, Billie Matchett, Adolfo G. Mauro, Eleonora Mezzaroma, Michael R. Milward, Ingrid Kazue Mizuno Watanabe, Natsuki Morimoto, Sandip Mukherjee, Mar Orzáez, Luke A.J. O'Neill, Pablo Pelegrín, Carolina Pellegrini, Anaïs Perrichet, Joanna Picó, Nicola Potere, Alexander Pronko, Kishore Aravind Ravichandran, Nicolas Riteau, Kim S. Robinson, Cédric Rébé, Fadi N. Salloum, Mónica Sancho, Andrew Sandstrom, Niels Olsen Saraiva Câmara, Florian I. Schmidt, Liang Shan, Eoin Silke, Paula M. Soriano-Teruel, Christian Stehlik, Heather Stout-Delgado, Arianne L. Theiss, Jenny P.-Y. Ting, Stefano Toldo, Elviche L. Tsakem, Rebecca E. Tweedell, Amalia Tzoumpa, K. Venuprasad, Rose Wellens, Robert Zeiser, Franklin L. Zhong, Alessia Zotta
Publikováno v:
Inflammasome Biology ISBN: 9780323918022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df40277879d3530be000cf63f0ec15f
https://doi.org/10.1016/b978-0-323-91802-2.01002-1
https://doi.org/10.1016/b978-0-323-91802-2.01002-1
Publikováno v:
Inflammasome Biology ISBN: 9780323918022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecaab5065f5428ac1dc812aa181179e4
https://doi.org/10.1016/b978-0-323-91802-2.00017-7
https://doi.org/10.1016/b978-0-323-91802-2.00017-7
Autor:
Benedikt, Kaufmann, Lin, Kui, Agustina, Reca, Aleksandra, Leszczynska, Andrea D, Kim, Laela M, Booshehri, Alexander, Wree, Helmut, Friess, Daniel, Hartmann, Lori, Broderick, Hal M, Hoffman, Ariel E, Feldstein
Publikováno v:
Cellular and molecular gastroenterology and hepatology, vol 14, iss 4
Background & aimsNonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. The NLRP3 inflammasome, a platform for caspase-1 activation and release of interleukin 1β, is increasingly recognized in the induction
Autor:
Benedikt Kaufmann, Aleksandra Leszczynska, Agustina Reca, Laela M Booshehri, Janset Onyuru, ZheHao Tan, Alexander Wree, Helmut Friess, Daniel Hartmann, Bettina Papouchado, Lori Broderick, Hal M Hoffman, Ben A Croker, Yanfang Peipei Zhu, Ariel E Feldstein
Publikováno v:
EMBO reports. 23
Sterile inflammation is a central element in liver diseases. The immune response following injurious stimuli involves hepatic infiltration of neutrophils and monocytes. Neutrophils are major effectors of liver inflammation, rapidly recruited to sites