Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Benedikt, Goretzki"'
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Oliver Simic, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Stimulator of interferon genes (STING) is a central component of the cytosolic nucleic acids sensing pathway and as such master regulator of the type I interferon response. Due to its critical role in physiology and its’ involvement in a v
Externí odkaz:
https://doaj.org/article/d64305878b7f4abe9dd92a3040e7b4f4
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large
Externí odkaz:
https://doaj.org/article/164d0c141a984b619e153ae313a859dd
Autor:
Arens Taga, Margo A. Peyton, Benedikt Goretzki, Thomas Q. Gallagher, Ann Ritter, Amy Harper, Thomas O. Crawford, Ute A. Hellmich, Charlotte J. Sumner, Brett A. McCray
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 3, Pp 375-391 (2022)
Abstract Objective Distinct dominant mutations in the calcium‐permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically cause nonoverlapping diseases of either the neuromuscular or skeletal systems. However, accumulating evid
Externí odkaz:
https://doaj.org/article/55b4815090ee4ddda93b31e6a1e0a6ea
Autor:
Brett A. McCray, Erika Diehl, Jeremy M. Sullivan, William H. Aisenberg, Nicholas W. Zaccor, Alexander R. Lau, Dominick J. Rich, Benedikt Goretzki, Ute A. Hellmich, Thomas E. Lloyd, Charlotte J. Sumner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of ne
Externí odkaz:
https://doaj.org/article/c12c32fb25af4c0fbec8907050b017a1
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Spider silk is of interest in material science research. Here the authors show that the tight binding of a spider silk protein domain relies on the amino acid methionine, which is abundant in the domain core where it facilitates dynamic shape adaptio
Externí odkaz:
https://doaj.org/article/cbb044ff25df467b8fda4b6d45554c9a
Autor:
Christoph Wiedemann, Benedikt Goretzki, Zoe N. Merz, Frederike Tebbe, Pauline Schmitt, Ute A. Hellmich
Publikováno v:
Biomolecular NMR Assignments. 16:289-296
The mammalian Transient Receptor Potential Vanilloid (TRPV) channels are a family of six tetrameric ion channels localized at the plasma membrane. The group I members of the family, TRPV1 through TRPV4, are heat-activated and exhibit remarkable polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883161995a24e3eebc9073bde0f5c4c8
https://doi.org/10.1007/s12104-022-10093-4
https://doi.org/10.1007/s12104-022-10093-4
Autor:
Merve Mutlu, Isabel Schmidt, Andrew I. Morrison, Benedikt Goretzki, Felix Freuler, Damien Begue, Nicolas Pythoud, Erik Ahrne, Sandra Kapps, Susan Roest, Debora Bonenfant, Delphine Jeanpierre, Thi-Thanh-Thao Tran, Rob Maher, Shaojian An, Amandine Rietsch, Florian Nigsch, Andreas Hofmann, John Reece-Hoyes, Christian N. Parker, Danilo Guerini
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2e8d59f2b3487af480f725db360e69
https://doi.org/10.1101/2023.02.08.527642
https://doi.org/10.1101/2023.02.08.527642
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44518da6b4f14f311d51b48232e18bc
https://doi.org/10.1101/2022.12.21.521430
https://doi.org/10.1101/2022.12.21.521430
Publikováno v:
Biomolecular NMR assignments. 16(2)
Transient receptor potential (TRP) channels are important pharmacological targets due to their ability to act as sensory transducers on the organismic and cellular level, as polymodal signal integrators and because of their role in numerous diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db60dc96ddb32b3b04587fb528bb441
https://pubmed.ncbi.nlm.nih.gov/35451798
https://pubmed.ncbi.nlm.nih.gov/35451798
Autor:
Stefan Schütz, Christian Bergsdorf, Benedikt Goretzki, Andreas Lingel, Martin Renatus, Alvar D. Gossert, Wolfgang Jahnke
Publikováno v:
Journal of Molecular Biology. 434:167833
The intrinsically disordered protein MYC belongs to the family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors (TFs). In complex with its cognate binding partner MAX, MYC preferentially binds to E-Box promotor sequences where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ee7d9298f979e00b96afd7e668bc1
https://doi.org/10.1016/j.jmb.2022.167833
https://doi.org/10.1016/j.jmb.2022.167833