Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Benedikt, Asbach"'
Autor:
Sneha Vishwanath, George William Carnell, Martina Billmeier, Luis Ohlendorf, Patrick Neckermann, Benedikt Asbach, Charlotte George, Maria Suau Sans, Andrew Chan, Joey Olivier, Angalee Nadesalingam, Sebastian Einhauser, Nigel Temperton, Diego Cantoni, Joe Grove, Ingo Jordan, Volker Sandig, Paul Tonks, Johannes Geiger, Christian Dohmen, Verena Mummert, Anne Rosalind Samuel, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-9 (2024)
Abstract Updates of SARS-CoV-2 vaccines are required to generate immunity in the population against constantly evolving SARS-CoV-2 variants of concerns (VOCs). Here we describe three novel in-silico designed spike-based antigens capable of inducing n
Externí odkaz:
https://doaj.org/article/82ef274560d34dc98c35687c198efcf5
Autor:
Patrick Neckermann, Madlen Mohr, Martina Billmeier, Alexander Karlas, Ditte R. Boilesen, Christian Thirion, Peter J. Holst, Ingo Jordan, Volker Sandig, Benedikt Asbach, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated
Externí odkaz:
https://doaj.org/article/04652d8cafeb4982bcb8ca46679fd314
Autor:
Beatriz Perdiguero, Alexandra Hauser, Carmen Elena Gómez, David Peterhoff, Elefthéria Sideris, Carlos Óscar S. Sorzano, Sarah Wilmschen, Marion Schaber, Laura Stengel, Benedikt Asbach, Song Ding, Dorothee Von Laer, Yves Levy, Giuseppe Pantaleo, Janine Kimpel, Mariano Esteban, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe generation of an HIV-1 vaccine able to induce long-lasting protective immunity remains a main challenge. Here, we aimed to modify next-generation soluble, prefusion-stabilized, close-to-native, glycan-engineered clade C gp140 envelope
Externí odkaz:
https://doaj.org/article/8678f1d6bd254349ba452be5f5fce815
Autor:
George W. Carnell, Martina Billmeier, Sneha Vishwanath, Maria Suau Sans, Hannah Wein, Charlotte L. George, Patrick Neckermann, Joanne Marie M. Del Rosario, Alexander T. Sampson, Sebastian Einhauser, Ernest T. Aguinam, Matteo Ferrari, Paul Tonks, Angalee Nadesalingam, Anja Schütz, Chloe Qingzhou Huang, David A. Wells, Minna Paloniemi, Ingo Jordan, Diego Cantoni, David Peterhoff, Benedikt Asbach, Volker Sandig, Nigel Temperton, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The accelerated development of the first generation COVID-19 vaccines has saved millions of lives, and potentially more from the long-term sequelae of SARS-CoV-2 infection. The most successful vaccine candidates have used the full-length SARS-CoV-2 s
Externí odkaz:
https://doaj.org/article/5fafe0eee11e411abff937e7564a9d5d
Autor:
Beatriz Perdiguero, Benedikt Asbach, Carmen E. Gómez, Josef Köstler, Susan W. Barnett, Marguerite Koutsoukos, Deborah E. Weiss, Anthony D. Cristillo, Kathryn E. Foulds, Mario Roederer, David C. Montefiori, Nicole L. Yates, Guido Ferrari, Xiaoying Shen, Sheetal Sawant, Georgia D. Tomaras, Alicia Sato, William J. Fulp, Raphael Gottardo, Song Ding, Jonathan L. Heeney, Giuseppe Pantaleo, Mariano Esteban, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific antibodies and, at the
Externí odkaz:
https://doaj.org/article/6036c61a4c684d169531306cb6b2b597
Autor:
Patrick Neckermann, Ditte Rahbaek Boilesen, Torsten Willert, Cordula Pertl, Silke Schrödel, Christian Thirion, Benedikt Asbach, Peter Johannes Holst, Ralf Wagner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Persistent human papillomavirus (HPV) infections are causative for cervical neoplasia and carcinomas. Despite the availability of prophylactic vaccines, morbidity and mortality induced by HPV are still too high. Thus, an efficient therapy, such as a
Externí odkaz:
https://doaj.org/article/cb37000a98b34924874487cd719fc1c7
Autor:
Kelly A. S. da Costa, Joanne Marie M. Del Rosario, Matteo Ferrari, Sneha Vishwanath, Benedikt Asbach, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1520 (2022)
To better understand how inhibition of the influenza neuraminidase (NA) protein contributes to protection against influenza, we produced lentiviral vectors pseudotyped with an avian H11 hemagglutinin (HA) and the NA of all influenza A (N1–N9) subty
Externí odkaz:
https://doaj.org/article/1f440601fb19487f84e9944df055f866
Autor:
David Peterhoff, Sebastian Einhauser, Stephanie Beileke, Hans-Helmut Niller, Felix Günther, Michael Schachtner, Benedikt Asbach, Philipp Steininger, Matthias Tenbusch, Antonia S. Peter, Andre Gessner, Ralph Burkhardt, Iris M. Heid, Ralf Wagner, Klaus Überla
Publikováno v:
Vaccines, Vol 10, Iss 2, p 324 (2022)
To assess vaccine immunogenicity in non-infected and previously infected individuals in a real-world scenario, SARS-CoV-2 antibody responses were determined during follow-up 2 (April 2021) of the population-based Tirschenreuth COVID-19 cohort study c
Externí odkaz:
https://doaj.org/article/f3d9ef5fbe344190848271f6388c70c0
Autor:
Alexander Thomas Sampson, Jonathan Heeney, Diego Cantoni, Matteo Ferrari, Maria Suau Sans, Charlotte George, Cecilia Di Genova, Martin Mayora Neto, Sebastian Einhauser, Benedikt Asbach, Ralf Wagner, Helen Baxendale, Nigel Temperton, George Carnell
Publikováno v:
Viruses, Vol 13, Iss 8, p 1579 (2021)
The novel coronavirus SARS-CoV-2 is the seventh identified human coronavirus. Understanding the extent of pre-existing immunity induced by seropositivity to endemic seasonal coronaviruses and the impact of cross-reactivity on COVID-19 disease progres
Externí odkaz:
https://doaj.org/article/f0dbf2fae91a450ab1b663d93e579583
Autor:
Joanne Marie M. Del Rosario, Kelly A. S. da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A. Wells, Gurdip Singh Mann, Veronica O. Ameh, Claude T. Sabeta, Ashley C. Banyard, Rebecca Kinsley, Simon D. Scott, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Publikováno v:
Vaccines, Vol 9, Iss 7, p 741 (2021)
We developed an influenza hemagglutinin (HA) pseudotype library encompassing Influenza A subtypes HA1-18 and Influenza B subtypes (both lineages) to be employed in influenza pseudotype microneutralization (pMN) assays. The pMN is highly sensitive and
Externí odkaz:
https://doaj.org/article/20645bc3db454cf08ad9a355855ec117