Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Benedicte A, Lie"'
Autor:
Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Pål Marius Bjørnstad, Maria Chernigovskaya, Quy Khang Le, Xavier Tekpli, Victor Greiff, Benedicte Alexandra Lie
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negative selection, or to agonist sel
Externí odkaz:
https://doaj.org/article/d5a96b0a6f914dc3b2b0e2e6a929aec5
Autor:
Marthe Ueland, Riad Hajdarevic, Olav Mella, Elin B. Strand, Daisy D. Sosa, Ola D. Saugstad, Øystein Fluge, Benedicte A. Lie, Marte K. Viken
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of symptoms such as post-exertional malaise, fatigue, and pain, but where aetiology and pathogenesis are unknown. An increasing number of studies have im
Externí odkaz:
https://doaj.org/article/b56bb96c126443c4b1e65929cd096284
Autor:
David J. Langton, Rohan M. Bhalekar, Thomas J. Joyce, Stephen P. Rushton, Benjamin J. Wainwright, Matthew E. Nargol, Nish Shyam, Benedicte A. Lie, Moreica B. Pabbruwe, Alan J. Stewart, Susan Waller, Shonali Natu, Renne Ren, Rachelle Hornick, Rebecca Darlay, Edwin P. Su, Antoni V. F. Nargol
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-12 (2022)
Plain language summary Millions of joint replacement surgeries are carried out across the world annually. In this surgery, the joint is replaced with an artificial implant. Most implants are made of cobalt chrome (CoCr). Some patients develop allergi
Externí odkaz:
https://doaj.org/article/c6f1f5e9d8674a9cb74fa7603dbbf39d
Autor:
Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Don Trinh, Michael Frisk, Karl-Andreas Dumont, Teodora Ribarska, Xavier Tekpli, Mario Saare, Benedicte Alexandra Lie
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and line
Externí odkaz:
https://doaj.org/article/8fa70d8dcdad4db181566a83767e34ff
Autor:
Maria Dehli Vigeland, Siri Tennebø Flåm, Magnus Dehli Vigeland, Ansgar Espeland, Per Martin Kristoffersen, Nils Vetti, Monica Wigemyr, Lars Christian Haugli Bråten, Elisabeth Gjefsen, Elina Iordanova Schistad, Anne Julsrud Haugen, Anne Froholdt, Jan Sture Skouen, John-Anker Zwart, Kjersti Storheim, Linda Margareth Pedersen, Benedicte Alexandra Lie, the AIM Study Group
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone
Externí odkaz:
https://doaj.org/article/2abb1ea3e4074eb08cd2be4fc3d9be88
Autor:
Maria Dehli Vigeland, Siri Tennebø Flåm, Magnus Dehli Vigeland, Ansgar Espeland, Manuela Zucknick, Monica Wigemyr, Lars Christian Haugli Bråten, Elisabeth Gjefsen, John-Anker Zwart, Kjersti Storheim, Linda Margareth Pedersen, Kaja Selmer, Benedicte Alexandra Lie, Kristina Gervin, The AIM Study Group
Publikováno v:
Antibiotics, Vol 12, Iss 7, p 1217 (2023)
Long-term antibiotics are prescribed for a variety of medical conditions, recently including low back pain with Modic changes. The molecular impact of such treatment is unknown. We conducted longitudinal transcriptome and epigenome analyses in patien
Externí odkaz:
https://doaj.org/article/642167277b8c4e4eafaa4d874192c719
Autor:
Elisabeth Gjefsen, Lars Christian Haugli Bråten, Guro Løvik Goll, Monica Wigemyr, Nils Bolstad, Morten Valberg, Elina Iordanova Schistad, Gunn Hege Marchand, Fredrik Granviken, Kaja Kristine Selmer, Anne Froholdt, Anne Julsrud Haugen, Magnhild Hammersland Dagestad, Nils Vetti, Gunnstein Bakland, Benedicte Alexandra Lie, Espen A. Haavardsholm, Aksel Thuv Nilsen, Thor Einar Holmgard, Thomas Istvan Kadar, Tore Kvien, Jan Sture Skouen, Lars Grøvle, Jens Ivar Brox, Ansgar Espeland, Kjersti Storheim, John Anker Zwart
Publikováno v:
BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized as Modic changes on m
Externí odkaz:
https://doaj.org/article/e9ce1cc99efa40358c1649a44a9788f5
Autor:
Genelle F Harrison, Laura Ann Leaton, Erica A Harrison, Katherine M Kichula, Marte K Viken, Jonathan Shortt, Christopher R Gignoux, Benedicte A Lie, Damjan Vukcevic, Stephen Leslie, Paul J Norman
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009059 (2022)
Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects severity of infections, immune-mediated disea
Externí odkaz:
https://doaj.org/article/a40864831cbd4d36b90418c41972b80d
Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells
Autor:
Hanna Helgeland, Ingvild Gabrielsen, Helle Akselsen, Arvind Y. M. Sundaram, Siri Tennebø Flåm, Benedicte Alexandra Lie
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background The thymus is a highly specialized organ of the immune system where T cell precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date have investigated how the human transcriptome profiles dif
Externí odkaz:
https://doaj.org/article/cb674693564f447e9069401c6fc14cfe
Autor:
Kari Guderud, Line H. Sunde, Siri T. Flåm, Marthe T. Mæhlen, Maria D. Mjaavatten, Ellen S. Norli, Ida M. Evenrød, Bettina K. Andreassen, Sören Franzenburg, Andre Franke, Simon Rayner, Kristina Gervin, Benedicte A. Lie
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundMethotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after treatment with MTX. We have investigated cell-type specific DNA methylation changes across the gen
Externí odkaz:
https://doaj.org/article/378fc971d1b14ca1be320098ff49f2fa