Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benedict Rauser"'
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Autor:
Jessica Giehrl‐Schwab, Florian Giesert, Benedict Rauser, Chu Lan Lao, Sina Hembach, Sandrine Lefort, Ignacio L Ibarra, Christina Koupourtidou, Malte Daniel Luecken, Dong‐Jiunn Jeffery Truong, Judith Fischer‐Sternjak, Giacomo Masserdotti, Nilima Prakash, Jovica Ninkovic, Sabine M Hölter, Daniela M Vogt Weisenhorn, Fabian J Theis, Magdalena Götz, Wolfgang Wurst
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-20 (2022)
Abstract Direct reprogramming based on genetic factors resembles a promising strategy to replace lost cells in degenerative diseases such as Parkinson's disease. For this, we developed a knock‐in mouse line carrying a dual dCas9 transactivator syst
Externí odkaz:
https://doaj.org/article/d6d64f7bdd884a3b9299b97fa956cf9b
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 15 (2022)
Background: Systematic data are lacking on the immune response toward SARS-CoV-2 mRNA vaccination in SPMS patients on disease-modifying therapies (DMTs). Objective: The AMA-VACC clinical trial was designed to characterize immune responses to SARS-CoV
Externí odkaz:
https://doaj.org/article/5a92a8a8e61b43089f2bfa495a309e66
Autor:
Tjalf Ziemssen, Gavin Giovannoni, Enrique Alvarez, Virender Bhan, Carrie Hersh, Olaf Hoffmann, Celia Oreja-Guevara, Rene R Robles-Cedeño, Maria Trojano, Patrick Vermersch, Pamela Dobay, Mudeer Khwaja, Bianca Stadler, Benedict Rauser, Thomas Hach, Daniela Piani-Meier, Jason Burton
Publikováno v:
Journal of Medical Internet Research, Vol 23, Iss 10, p e29558 (2021)
BackgroundA digital tool, Multiple Sclerosis Progression Discussion Tool (MSProDiscuss), was developed to facilitate discussions between health care professionals (HCPs) and patients in evaluating early, subtle signs of multiple sclerosis (MS) diseas
Externí odkaz:
https://doaj.org/article/1a5b6a9f29e74885b0c70faf27a2f77e
Autor:
Parivash Nouri, Sebastian Götz, Benedict Rauser, Martin Irmler, Changgeng Peng, Dietrich Trümbach, Christian Kempny, Carina G. Lechermeier, Agnes Bryniok, Andrea Dlugos, Ellen Euchner, Johannes Beckers, Claude Brodski, Claudia Klümper, Wolfgang Wurst, Nilima Prakash
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The mesodiencephalic dopaminergic (mdDA) neurons, including the nigrostriatal subset that preferentially degenerates in Parkinson’s Disease (PD), strongly depend on an accurately balanced Wingless-type MMTV integration site family member 1 (WNT1)/b
Externí odkaz:
https://doaj.org/article/73bd6bb691e544a681511de22951a276
Autor:
Tjalf Ziemssen, Virender Bhan, Jeremy Chataway, Tanuja Chitnis, Bruce Anthony Campbell Cree, Eva Kubala Havrdova, Ludwig Kappos, Pierre Labauge, Aaron Miller, Jin Nakahara, Celia Oreja-Guevara, Jacqueline Palace, Barry Singer, Maria Trojano, Ashwini Patil, Benedict Rauser, Thomas Hach
Publikováno v:
Neurology - Neuroimmunology Neuroinflammation. 10:e200064
Many challenges exist in the precise diagnosis and clinical management of secondary progressive multiple sclerosis (SPMS) because of the lack of definitive clinical, imaging, immunologic, or pathologic criteria that demarcate the transition from rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c61df2ffce525410395118155772011
https://doi.org/10.1212/nxi.0000000000200064
https://doi.org/10.1212/nxi.0000000000200064
Autor:
Tjalf Ziemssen, Gavin Giovannoni, Enrique Alvarez, Virender Bhan, Carrie Hersh, Olaf Hoffmann, Celia Oreja-Guevara, Rene R Robles-Cedeño, Maria Trojano, Patrick Vermersch, Pamela Dobay, Mudeer Khwaja, Bianca Stadler, Benedict Rauser, Thomas Hach, Daniela Piani-Meier, Jason Burton
BACKGROUND A digital tool, Multiple Sclerosis Progression Discussion Tool (MSProDiscuss), was developed to facilitate discussions between health care professionals (HCPs) and patients in evaluating early, subtle signs of multiple sclerosis (MS) disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa30121ac83f8a41a52cee3255c570d
https://doi.org/10.2196/preprints.29558
https://doi.org/10.2196/preprints.29558
Autor:
Niklas Frahm, Firas Fneish, Vroni Vogelmann, Benedict Rauser, Uwe K. Zettl, David Ellenberger, Alexander Stahmann, Friedemann Friedemann, Clemens Warnke, Peter Flachenecker, Kleinschnitz Christoph
Publikováno v:
Multiple sclerosis and related disorders. 56
Background The tailored immunomodulatory treatment strategy for secondary progressive multiple sclerosis (SPMS) depends on disease activity. Objective To assess the real-world situation in monitoring disease activity in SPMS patients and to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12dc40cfdfa5aaac673c903f684d81e8
https://pubmed.ncbi.nlm.nih.gov/34624644
https://pubmed.ncbi.nlm.nih.gov/34624644
Publikováno v:
Multiple sclerosis and related disorders. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85c4eb210095a0e90114a3104bff305
https://pubmed.ncbi.nlm.nih.gov/32977073
https://pubmed.ncbi.nlm.nih.gov/32977073
Autor:
Tjalf Ziemssen, Luisa Klotz, Herbert Schreiber, Olaf Hoffmann, Martin S. Weber, Benedict Rauser
Publikováno v:
JMIR Research Protocols, Vol 9, Iss 7, p e19598 (2020)
JMIR Research Protocols
JMIR Research Protocols
Background A high proportion of patients with relapsing remitting multiple sclerosis convert to secondary progressive multiple sclerosis (SPMS) characterized by irreversibly progressing disability and cognitive decline. Siponimod (Mayzent), a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012c923739edf45b6ab677145a34b94b
http://www.researchprotocols.org/2020/7/e19598/
http://www.researchprotocols.org/2020/7/e19598/
Autor:
Tjalf Ziemssen, Olaf Hoffmann, Luisa Klotz, Herbert Schreiber, Martin S Weber, Benedict Rauser
BACKGROUND A high proportion of patients with relapsing remitting multiple sclerosis convert to secondary progressive multiple sclerosis (SPMS) characterized by irreversibly progressing disability and cognitive decline. Siponimod (Mayzent), a selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f4ff816616ec58de6aa6eb6ba3777c
https://doi.org/10.2196/preprints.19598
https://doi.org/10.2196/preprints.19598