Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Benedict R Capacio"'
Autor:
Jamal Chauhan, Steven Cardinale, Lei Fang, Jing Huang, Steven M Kwasny, M Ross Pennington, Kelly Basi, Robert diTargiani, Benedict R Capacio, Alexander D MacKerell, Timothy J Opperman, Steven Fletcher, Erik P H de Leeuw
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164515 (2016)
Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E,3E)-3-(1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)pyryl-1-ium) tetrafluoroborate is the first small molecul
Externí odkaz:
https://doaj.org/article/3b20d0e6c31f4ac6bf0d0a03d1cf8c71
Publikováno v:
Drug and Chemical Toxicology. 45:2185-2192
Prolonged seizures are a hallmark feature of intoxication with anticholinesterase nerve agents such as soman. While benzodiazepine drugs are typically used to control these seizures, studies in both rats and guinea pigs have shown that potent, centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5e8fb9c0229429227a5423200f84ae
https://doi.org/10.1080/01480545.2021.1916171
https://doi.org/10.1080/01480545.2021.1916171
Autor:
Sheena A Young, Benedict R. Capacio
Publikováno v:
Chemical research in toxicology. 33(7)
Exposures to sulfur mustard (HD; bis(2-chloroethyll) sulfide) are well-known to result in the formation of adducts with free aspartate and glutamate residues of plasma proteins (Lawrence, R. J., Smith, J. R., and Capacio, B. R. 2008 32, (1), 31-36).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66012f603eb0c121f7de03a9c548e1de
https://pubmed.ncbi.nlm.nih.gov/32567850
https://pubmed.ncbi.nlm.nih.gov/32567850
Autor:
Tamara C. Otto, Sean M. Hodgins, Douglas M. Cerasoli, Benedict R. Capacio, Robyn B. Lee-Stubbs, David E. Lenz, C. Linn Cadieux, Stuart J. Armstrong, Tony E. Reeves, Shane A. Kasten
Publikováno v:
Biochemical pharmacology. 171
Human butyrylcholinesterase (E.C. 3.1.1.8) purified from blood plasma has previously been shown to provide protection against up to five and a half times the median lethal dose of an organophosphorus nerve agent in several animal models. In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c33ce0a3135f70c40f82a482a17a538
https://pubmed.ncbi.nlm.nih.gov/31628910
https://pubmed.ncbi.nlm.nih.gov/31628910
Autor:
M. Ross Pennington, J. Richard Smith, Julian R. Haigh, Robert C. diTargiani, Brian J. Lukey, Benedict R. Capacio, Daniel Noort, John R. Barr, Richard K. Gordon
Publikováno v:
Chemical Warfare Agents ISBN: 9781498769235
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527716bca2c60455de9d1567a2262e9e
https://doi.org/10.1201/9781498769235-20
https://doi.org/10.1201/9781498769235-20
Publikováno v:
Toxicology and Applied Pharmacology. 415:115443
The brain is a critical target for the toxic action of organophosphorus (OP) inhibitors of acetylcholinesterase (AChE) such as the nerve agent sarin. However, the available oxime antidote 2-PAM only reactivates OP-inhibited AChE in peripheral tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a58cfe4cf6fe3e7b7bf9fc2162bbed
https://doi.org/10.1016/j.taap.2021.115443
https://doi.org/10.1016/j.taap.2021.115443
Autor:
Sheena A Young, Benedict R. Capacio
Publikováno v:
Journal of analytical toxicology. 43(3)
The development of one comprehensive gas chromatographic-triple quadrupole mass spectrometric (GC-MS-MS) method for the analysis of nerve agents and their breakdown products can pose a challenge due to significant differences in analyte volatility. N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f4a5f3dcbb4631024e65046e7571b4
https://pubmed.ncbi.nlm.nih.gov/30364974
https://pubmed.ncbi.nlm.nih.gov/30364974
Autor:
Benedict R. Capacio, Sunil D. Soni, Paul Chen, Susan M. Schultz, Irwin Koplovitz, Edward D. Clarkson, Julia Morgan
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd350ac7773744419d5ec7d2c7a9fa8a
https://doi.org/10.1096/fasebj.2018.32.1_supplement.691.2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.691.2
Autor:
Samantha R. Litvin, Sunil D. Soni, Sheena A Young, David A Orsini, Robert C. diTargiani, Justin N. Vignola, Amy S Rizkallah, Veera Venkata Ratnam Bandaru, Amber M Packer, M. Ross Pennington, Benedict R. Capacio
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999a473ebc4bb4cc4f44382e36691cc0
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb93
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb93
Autor:
Alexander D. MacKerell, Jing Huang, Robert C. diTargiani, Lei Fang, Timothy J. Opperman, Steven M. Kwasny, Erik de Leeuw, Benedict R. Capacio, M. Ross Pennington, Steven C. Cardinale, Kelly A. Basi, Steven Fletcher, Jamal Chauhan
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164515 (2016)
PLoS ONE
PLoS ONE
Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E,3E)-3-(1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)pyryl-1-ium) tetrafluoroborate is the first small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5987358213d373068f9a20741f6783
http://europepmc.org/articles/PMC5077133?pdf=render
http://europepmc.org/articles/PMC5077133?pdf=render