Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Benedict Pereira"'
Publikováno v:
Stroke. 53
Introduction: Transcranial Doppler (TCD) is a commonly used testing modality in the diagnosis of cerebral circulatory arrest (CCA). There is currently no consensus in the United States for which vessels must be insonated to establish a CCA diagnosis.
Autor:
Patrick D. Lyden, I-Farn Lei, Jilin Bai, John H. Griffin, José A. Fernández, Padmesh S. Rajput, Jessica Lamb, Jennifer Leung, Benedict Pereira
Publikováno v:
Brain Res
Thrombin and activated protein C (APC) are known coagulation factors that exhibit profound effects in brain by acting on the protease activated receptor (PAR). The wild type (WT) proteases appear to impact cell survival powerfully, and therapeutic fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9225bd3ef5328307365b75855fe896
https://europepmc.org/articles/PMC6500472/
https://europepmc.org/articles/PMC6500472/
Autor:
Jennifer E. Van Eyk, Daniel Soetkamp, Padmesh S. Rajput, Jessica Lamb, Eric S. Mullins, Yizhou Wang, Patrick D. Lyden, Benedict Pereira, Jie Tang, Shweta Kothari
Publikováno v:
Glia
Astrocytes protect neurons during cerebral injury through several postulated mechanisms. Recent therapeutic attention has focused on enhancing or augmenting the neuroprotective actions of astrocytes but in some instances astrocytes can assume a neuro
Autor:
Benedict Pereira, Padmesh S. Rajput, Lifu Zhao, Bo Chen, Jessica Lamb, Patrick D. Lyden, I-Farn Lei
Publikováno v:
Stroke. 45:896-899
Background and Purpose— We showed previously robust neuroprotection with the thrombin inhibitor argatroban and now sought additional support for its neuroprotective potential. Methods— We used behavioral and histological end points; rigorously bl
Autor:
Padmesh S. Rajput, Patrick D. Lyden, Alexander W. Lamb, Bo Chen, Lifu Zhao, Benedict Pereira, Jilin Bai, Jessica Lamb, I-Farn Lei
Protease activated receptors (PARs) populate neurons and astrocytes in the brain. The serine protease thrombin, which activates PAR-1 during the first hours after stroke, appears to be associated with the cytotoxicity. Thrombin antagonists and PAR-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81651cb063974de5d682ba2107b0ac3f
https://europepmc.org/articles/PMC4377119/
https://europepmc.org/articles/PMC4377119/
Publikováno v:
Stroke. 45
Background and Purpose: We showed previously that thrombin enters brain and causes damage to the neurovascular unit (NVU) during ischemia. We hypothesized that the direct thrombin inhibitor argatroban after MCAo would ameliorate behavioral deficits.
Autor:
Patrick D. Lyden, Padmesh S. Rajput, Benedict Pereira, I.-Farn Lei, Bo Chen, Jessica A. Van Winkle
Publikováno v:
Journal of neuroscience methods. 213(1)
Pre-clinical development of therapy for acute ischemic stroke requires robust animal models; the rodent middle cerebral artery occlusion (MCAo) model using a nylon filament inserted into the internal carotid artery is the most popular. Drug screening
Autor:
Michael A. Whitney, Beth Friedman, Lifu Zhao, Roger Y. Tsien, I-Farn Lei, Patrick D. Lyden, Jessica A. Van Winkle, Bo Chen, Qun Cheng, Emilia S. Olson, Benedict Pereira
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(22)
Mechanisms of ischemic neuronal and vascular injury remain obscure. Here we test the hypothesis that thrombin, a blood-borne coagulation factor, contributes to neurovascular injury during acute focal ischemia. Stroke was induced in adult Sprague Dawl