Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Benedict C, Albensi"'
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial dysfunction and associated inflammatory signaling are pivotal in both aging and in Alzheimer’s disease (AD). Studies have also shown that hypothalamic function is affected in AD. The hypothalamus may be a target for AD drugs
Externí odkaz:
https://doaj.org/article/a114024dc7f94d288192c600397db89d
Autor:
Darcy Tocci, Tomas Ducai, C. A. Barry Stoute, Gabrielle Hopkins, Mohammad G. Sabbir, Afshin Beheshti, Benedict C. Albensi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The possibility of impaired cognitive function during deep space flight missions or while living on a Martian colony is a critical point of concern and pleads for further research. In addition, a fundamental gap exists both in our understanding and a
Externí odkaz:
https://doaj.org/article/cb42008fe6ea4755b919957a7810ba57
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: In a previous retrospective study using postmortem human brain tissues, we demonstrated that loss of Cholinergic Receptor Muscarinic 1 (CHRM1) in the temporal cortex of a subset of Alzheimer’s patients was associated with poor surviva
Externí odkaz:
https://doaj.org/article/1e25e7ee01224971b2338ad696fc4597
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Cholinergic Receptor Muscarinic 1 (CHRM1) is a G protein-coupled acetylcholine (ACh) receptor predominantly expressed in the cerebral cortex. In a retrospective postmortem brain tissues-based study, we demonstrated that severely (≥50%
Externí odkaz:
https://doaj.org/article/1cda8697117f4481a0288c0bd30d5143
Autor:
Sophia Mirkin, Benedict C. Albensi
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that affects memory, thinking, behavior, and other cognitive functions. Although there is no cure, detecting AD early is important for the development of a therapeutic plan and a
Externí odkaz:
https://doaj.org/article/0296fde855c044f3a868f92364432437
Autor:
Aida Adlimoghaddam, Wanda M. Snow, Greg Stortz, Claudia Perez, Jelena Djordjevic, Andrew L. Goertzen, Ji Hyun Ko, Benedict C. Albensi
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 264-277 (2019)
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. Although neurofibrillary tangles and amyloid beta are classic hallmarks of AD, the earliest deficits in AD progression may be caused by unknown factors. One suspected fa
Externí odkaz:
https://doaj.org/article/0200efb1991c48489b39efed5b6db455
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Dementia is an umbrella term—caused by a large number of specific diagnoses, including several neurodegenerative disorders. Alzheimer's disease (AD) is now the most common cause of dementia in advanced countries, while dementia due to neurosyphilis
Externí odkaz:
https://doaj.org/article/3ac41bf30dec4f0ebba0502a21bc0e11
Autor:
Hussein N. Yassine, Wade Self, Bilal E. Kerman, Giulia Santoni, NandaKumar Navalpur Shanmugam, Laila Abdullah, Lesley R. Golden, Alfred N. Fonteh, Michael G. Harrington, Johannes Gräff, Gary E. Gibson, Raj Kalaria, Jose A. Luchsinger, Howard H. Feldman, Russell H. Swerdlow, Lance A. Johnson, Benedict C. Albensi, Berislav V. Zlokovic, Rudolph Tanzi, Stephen Cunnane, Cécilia Samieri, Nikolaos Scarmeas, Gene L. Bowman
Publikováno v:
Alzheimer's & Dementia. 19:1041-1066
Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610baf6bd459f153d922cbd98565ac79
https://doi.org/10.1002/alz.12845
https://doi.org/10.1002/alz.12845
Autor:
Benedict C. Albensi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
A large body of literature supports the idea that nuclear factor kappa B (NF-κB) signaling contributes to not only immunity, but also inflammation, cancer, and nervous system function. However, studies on NF-κB activity in mitochondrial function ar
Externí odkaz:
https://doaj.org/article/0604978966f447139bcd7ef592d7c99b
Publikováno v:
Cells, Vol 10, Iss 8, p 1884 (2021)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcription factor that reduces oxidative stress. When reactive oxygen species (ROS) or reactive nitrogen species (RNS) are detected, Nrf2 translocates from the cytoplasm into the n
Externí odkaz:
https://doaj.org/article/559b9d4a019143e794ca95fb8d4a033f