Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Benedict, Seddon"'
Autor:
M Elise Bullock, Thea Hogan, Cayman Williams, Sinead Morris, Maria Nowicka, Minahil Sharjeel, Christiaan van Dorp, Andrew J Yates, Benedict Seddon
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002380 (2024)
Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central mem
Externí odkaz:
https://doaj.org/article/95c8fb670bbc40b195dd7e6e7aec8d73
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The dynamics of cell populations are frequently studied in vivo using pulse-chase DNA labeling techniques. When combined with mathematical models, the kinetic of label uptake and loss within a population of interest then allows one to estimate rates
Externí odkaz:
https://doaj.org/article/aac52fca7da34e0b83932c702b277971
Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells
Autor:
Sam Blanchett, Yves Dondelinger, Alessandro Barbarulo, Mathieu J. M. Bertrand, Benedict Seddon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-κB activation. More recently, IKK has also been shown to repress RIPK1 dependent extrinsic cell death pathways by directly phosphorylating RIPK1 at serine 25. In T cells, IK
Externí odkaz:
https://doaj.org/article/19e6cf8ee5f842abb86b828c6755a8fa
Publikováno v:
eLife, Vol 11 (2022)
Naive CD4 and CD8 T cells are cornerstones of adaptive immunity, but the dynamics of their establishment early in life and how their kinetics change as they mature following release from the thymus are poorly understood. Further, due to the diverse s
Externí odkaz:
https://doaj.org/article/1672013e0f1a4741bfb077a6afca2a2b
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108376- (2020)
Summary: Follicular mature (FM) and germinal center (GC) B cells underpin humoral immunity, but the dynamics of their generation and maintenance are not clearly defined. Here, we exploited a fate-mapping system in mice that tracks B cells as they dev
Externí odkaz:
https://doaj.org/article/ec56e120c6a942dda905ec078bac470e
Publikováno v:
eLife, Vol 8 (2019)
Laboratory mice develop populations of circulating memory CD4+ T cells in the absence of overt infection. We have previously shown that these populations are replenished from naive precursors at high levels throughout life (Gossel et al., 2017). Howe
Externí odkaz:
https://doaj.org/article/96567a4133f546699da8b9140eb311df
Autor:
João T. Barata, Benedict Seddon, J. Andrés Yunes, Jocelyne Demengeot, Bruno A. Cardoso, Leila R. Martins, Angelo B.A. Laranjeira, Ana Silva
Supplementary Figures 1-4 from IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4493bcc2174e1faf0bb6ff445c1dc3f2
https://doi.org/10.1158/0008-5472.22388313.v1
https://doi.org/10.1158/0008-5472.22388313.v1
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2003949 (2018)
The processes regulating peripheral naive T-cell numbers and clonal diversity remain poorly understood. Conceptually, homeostatic mechanisms must fall into the broad categories of neutral (simple random birth-death models), competition (regulation of
Externí odkaz:
https://doaj.org/article/953a414d97284e54a97a2c183fb8738a
Publikováno v:
Bio-Protocol, Vol 7, Iss 24 (2017)
This protocol was developed to increase the richness of information available from in vivo T cell proliferation studies. DNA labelling techniques such as BrdU incorporation allow precise control of label administration and withdrawal, so that the div
Externí odkaz:
https://doaj.org/article/2fc7caee8a284a78ad6049870c58e982
Publikováno v:
Bio-Protocol, Vol 7, Iss 24 (2017)
This protocol was developed to generate chimeric mice in which T lymphocytes could be stratified by age on the basis of congenic marker expression. The conditioning drug busulfan is used to ablate host haematopoietic stem cells while leaving the peri
Externí odkaz:
https://doaj.org/article/ff0ad5f9205f4181955468758a60d174