Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Benedetto Daniele, Giaimo"'
Autor:
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH rec
Externí odkaz:
https://doaj.org/article/e94caf3b118449feae916a319b8e5115
Autor:
Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, Joost Gribnau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
Externí odkaz:
https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/25975dc79c764028a201b22db72cf816
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake, Tilman Borggrefe
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer. Here, we review the recent dev
Externí odkaz:
https://doaj.org/article/ed61ab6b1cc341758a41c4005dc851bd
Autor:
Juan Rodriguez-Vita, Andreas Fischer, Tilman Borggrefe, Adelheid Cerwenka, Benedetto Daniele Giaimo, Adrian Stögbauer, Francesca De Angelis Rigotti, Jacqueline Taylor, Eleni Zimmer, Tara Ziegelbauer, Lorea Jordana-Urriza, Lena Wiedmann, Sarah Böhn, Iris Moll, Ronja Mülfarth, Elisenda Alsina-Sanchis
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironment (TME). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eee1b23eccf95afa3f52802589d35780
https://doi.org/10.1158/0008-5472.c.6514245.v1
https://doi.org/10.1158/0008-5472.c.6514245.v1
Autor:
Juan Rodriguez-Vita, Andreas Fischer, Tilman Borggrefe, Adelheid Cerwenka, Benedetto Daniele Giaimo, Adrian Stögbauer, Francesca De Angelis Rigotti, Jacqueline Taylor, Eleni Zimmer, Tara Ziegelbauer, Lorea Jordana-Urriza, Lena Wiedmann, Sarah Böhn, Iris Moll, Ronja Mülfarth, Elisenda Alsina-Sanchis
It includes extended material and methods, and supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1029341a0d2ff1ed3e5aa52aaeb1e46a
https://doi.org/10.1158/0008-5472.22432767
https://doi.org/10.1158/0008-5472.22432767
Autor:
Tobias Friedrich, Francesca Ferrante, Léo Pioger, Andrea Nist, Thorsten Stiewe, Jean-Christophe Andrau, Marek Bartkuhn, Benedetto Daniele Giaimo, Tilman Borggrefe
Publikováno v:
Nucleic acids research. 50(14)
Signal transduction pathways often involve transcription factors that promote activation of defined target gene sets. The transcription factor RBPJ is the central player in Notch signaling and either forms an activator complex with the Notch intracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80d1d7889ebc9d6de3c07028b9064f6
https://pubmed.ncbi.nlm.nih.gov/35848919
https://pubmed.ncbi.nlm.nih.gov/35848919
Autor:
Tilman Borggrefe, Marek Bartkuhn, Thorsten Stiewe, Patricia Klöble, Daniel Mertens, Francesca Ferrante, Andrea Nist, Steffen Just, Viola Close, Johanna Meier-Soelch, Benedetto Daniele Giaimo, Franz Oswald, Michael Kracht, Tobias Zimmermann
Publikováno v:
Nucleic Acids Research
Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d336560bd7dff5889b69f6093f682
http://europepmc.org/articles/PMC7144913
http://europepmc.org/articles/PMC7144913
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89148f62ae614e32506b6ec7f5cac653
https://pubmed.ncbi.nlm.nih.gov/34382191
https://pubmed.ncbi.nlm.nih.gov/34382191