Multilevel X-ray imaging approach to assess the sequential evolution of multi-organ damage in multiple sclerosis

Autor: Francesca Palermo, Nicola Pieroni, Alessia Sanna, Benedetta Parodi, Consuelo Venturi, Ginevra Begani Provinciali, Lorenzo Massimi, Laura Maugeri, Gian Paolo Marra, Elena Longo, Lorenzo D’Amico, Giulia Saccomano, Jonathan Perrin, Giuliana Tromba, Inna Bukreeva, Michela Fratini, Giuseppe Gigli, Nicole Kerlero de Rosbo, Alessia Cedola

Publikováno v: Communications Physics, Vol 5, Iss 1, Pp 1-12 (2022)

X-ray phase-contrast tomography offers a highly sensitive 3D imaging approach to investigate different disease-relevant networks at levels ranging from single cell through to intact organ. The authors present a concomitant study of the evolution of t

Externí odkaz: https://doaj.org/article/5feaf8f1f96742e7acf3226f5b59ab42

Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS

Autor: Francesca Provenzano, Sophie Nyberg, Debora Giunti, Carola Torazza, Benedetta Parodi, Tiziana Bonifacino, Cesare Usai, Nicole Kerlero de Rosbo, Marco Milanese, Antonio Uccelli, Pamela J. Shaw, Laura Ferraiuolo, Giambattista Bonanno

Publikováno v: Cells, Vol 11, Iss 23, p 3923 (2022)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no effective cure. Astrocytes display a toxic phenotype in ALS and contribute to motoneuron (MN) degeneration. Modulating astrocytes’ neurotoxicity can reduce MN death. Our pre

Externí odkaz: https://doaj.org/article/67adbb1742a94f2bae3e34e04e252b01

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

Autor: Benedetta Parodi, Alessia Sanna, Alessia Cedola, Antonio Uccelli, Nicole Kerlero de Rosbo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Monomethyl fumarate (MMF), metabolite of dimethyl fumarate (DMF), an immunosuppressive drug approved for the treatment of multiple sclerosis (MS), is a potent agonist for hydroxycarboxylic acid receptor 2 (HCAR2), eliciting signals that dampen cell a

Externí odkaz: https://doaj.org/article/9f3716ca1e8146abbea98e12f039efa6

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

Autor: Robert H. Scannevin, Silvia Rossi, Sara Morando, Benedetta Parodi, Antonio Uccelli, Brian T. Wipke, Caterina Motta, Nicole Kerlero de Rosbo, Giovanni Luigi Mancardi, Cesare Usai, Alberto Bragoni, Diego Centonze, Christian Cordano

Publikováno v: Acta Neuropathologica
Acta neuropathologica 130 (2015): 279–295. doi:10.1007/s00401-015-1422-3
info:cnr-pdr/source/autori:Parodi B.; Rossi S.; Morando S.; Cordano C.; Bragoni A.; Motta C.; Usai C.; Wipke B.T.; Scannevin R.H.; Mancardi G.L.; Centonze D.; Kerlero de Rosbo N.; Uccelli A./titolo:Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS/doi:10.1007%2Fs00401-015-1422-3/rivista:Acta neuropathologica/anno:2015/pagina_da:279/pagina_a:295/intervallo_pagine:279–295/volume:130

Dimethyl fumarate (DMF), recently approved as an oral immunomodulatory treatment for relapsing-remitting multiple sclerosis (MS), metabolizes to monomethyl fumarate (MMF) which crosses the blood–brain barrier and has demonstrated neuroprotective ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b7cd4f7fd444a5c9904fd90ef84858
http://hdl.handle.net/11567/809538

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis

Autor: Antonio Uccelli, Nicole Kerlero de Rosbo, Debora Giunti, Benedetta Parodi, Christian Cordano

Microglia cells, the resident innate immune cells in the brain, are highly active, extending and retracting highly motile processes through which they continuously survey their microenvironment for 'danger signals' and interact dynamically with surro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d77a5c28d0433a97ee8f90d6fe3d01
http://hdl.handle.net/11567/691397