Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Benedetta Mannini"'
Autor:
Michele Perni, Benedetta Mannini, Catherine K. Xu, Janet R. Kumita, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Misfolded protein oligomers are increasingly recognized as highly cytotoxic agents in a wide range of human disorders associated with protein aggregation. In this study, we assessed the possible uptake and resulting toxic effects of model pr
Externí odkaz:
https://doaj.org/article/a5a3433026d44b8ebabead4cd9d9b713
Autor:
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Joshi et al. identify two human metabolites, carnosine and kynurenic acid, that rescue a C. elegans model of Alzheimer’s disease by inhibiting the aggregation of the amyloid beta peptide in vivo. They find that these metabolites trigger a cytosolic
Externí odkaz:
https://doaj.org/article/b28a52b5717142fcbc1079229aedf157
Autor:
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Cataldi et al. investigates the impact of the dopamine derivative DOPAL on the Aβ peptide oligomer formation. They report that DOPAL promotes the formation of stable Aβ oligomers that exert toxicity on neuroblastoma cells by increasing cytosolic ca
Externí odkaz:
https://doaj.org/article/4d14647112154fb9bb2c49c0fb14d6b7
Autor:
Francesco Simone Ruggeri, Benedetta Mannini, Roman Schmid, Michele Vendruscolo, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
While infrared nanospectroscopy methods based on thermomechanical detection (AFM-IR) enables the acquisition of absorption spectra at the nanoscale, single molecule detection has not been possible so far. Here, the authors present off-resonance, low
Externí odkaz:
https://doaj.org/article/75fd9014aacf4a8eacc2ca3e369c4d03
Autor:
Diana C. Rodriguez Camargo, Sean Chia, Joseph Menzies, Benedetta Mannini, Georg Meisl, Martin Lundqvist, Christin Pohl, Katja Bernfur, Veronica Lattanzi, Johnny Habchi, Samuel IA Cohen, Tuomas P. J Knowles, Michele Vendruscolo, Sara Linse
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is resolved in terms of the unde
Externí odkaz:
https://doaj.org/article/06a8b25e7ff84e83a621b38a48768838
Autor:
Ryan Limbocker, Roxine Staats, Sean Chia, Francesco S. Ruggeri, Benedetta Mannini, Catherine K. Xu, Michele Perni, Roberta Cascella, Alessandra Bigi, Liam R. Sasser, Natalie R. Block, Aidan K. Wright, Ryan P. Kreiser, Edward T. Custy, Georg Meisl, Silvia Errico, Johnny Habchi, Patrick Flagmeier, Tadas Kartanas, Jared E. Hollows, Lam T. Nguyen, Kathleen LeForte, Denise Barbut, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Tuomas P. J. Knowles, Christopher M. Dobson, Fabrizio Chiti, Michele Vendruscolo
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The aberrant aggregation of proteins is a key molecular event in the development and progression of a wide range of neurodegenerative disorders. We have shown previously that squalamine and trodusquemine, two natural products in the aminosterol class
Externí odkaz:
https://doaj.org/article/dd03b8d056964d40bab6c08d74df6acb
Autor:
Ryan Limbocker, Sean Chia, Francesco S. Ruggeri, Michele Perni, Roberta Cascella, Gabriella T. Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C. T. Michaels, Pavan K. Challa, Minkoo Ahn, Samuel T. Casford, Nilumi Fernando, Catherine K. Xu, Nina D. Kloss, Samuel I. A. Cohen, Janet R. Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P. J. Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M. Dobson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Transient oligomeric species of the amyloid-β peptide (Aβ42) have been identified as key pathogenic agents in Alzheimer’s disease. Here the authors find that the aminosterol trodusquemine enhances Aβ42 aggregation and suppresses Aβ42-induced to
Externí odkaz:
https://doaj.org/article/e4aca3eea6e44315b03de5b6488da79d
Autor:
Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Publikováno v:
Molecules, Vol 27, Iss 4, p 1293 (2022)
A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the s
Externí odkaz:
https://doaj.org/article/22de59ffd416471b9dbd2a4adc27aee5
Autor:
Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/e05a7e29f624432dae137b070cefae43
Autor:
Rodrigo Cataldi, Sean Chia, Katarina Pisani, Francesco S. Ruggeri, Catherine K. Xu, Tomas Šneideris, Michele Perni, Sunehera Sarwat, Priyanka Joshi, Janet R. Kumita, Sara Linse, Johnny Habchi, Tuomas P. J. Knowles, Benedetta Mannini, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-01680-7
Externí odkaz:
https://doaj.org/article/dfee79f008f742058b9470e8d55da296