Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Benedetta, Pollarolo"'
Autor:
Benedetta Pollarolo, M. Mazzei, Luis J. V. Galietta, Erika Nieddu, Maria Anzaldi, Mauro Mazzei, Silvia Schenone, Nicoletta Pedemonte
Publikováno v:
Archiv der Pharmazie. 349:112-123
The phenylhydrazone RDR-1 is endowed with moderate activity as F508del-CFTR corrector; nevertheless, its simple structure enables stimulating developments in this class of correctors. Therefore, we synthesized a number of phenylhydrazones 3 by reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3ad98e2d4821395e186f84ab70bb48
https://doi.org/10.1002/ardp.201500352
https://doi.org/10.1002/ardp.201500352
Autor:
Cinzia Domenicotti, Benedetta Pollarolo, Francesca Musumeci, Andrea Speciale, Mauro Mazzei, Lisa Senatore, Barbara Marengo, Silvano Garibaldi, Maria Adelaide Pronzato, Silvia Schenone, Erika Nieddu
Publikováno v:
Molecular Medicine Reports
Cystic fibrosis is caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and the predominant mutation is termed Phe508del (F508del). Therapy for F508del‑CFTR patients is based on the use of Orkambi®, a combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6dc270abac54d48fc563966a8ea8af
http://hdl.handle.net/11567/877175
http://hdl.handle.net/11567/877175
Autor:
Luis J. V. Galietta, Erika Nieddu, Benedetta Pollarolo, Mauro Mazzei, M. Mazzei, Maria Anzaldi, Emanuela Pesce, Silvia Schenone, Nicoletta Pedemonte
Publikováno v:
Future Medicinal Chemistry. 6:1857-1868
Background: The F508del mutation impairs the trafficking of CFTR from endoplasmic reticulum to plasma membrane and is responsible of a severe form of cystic fibrosis. Trafficking can be improved by small organic molecules called 'correctors'. Materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98828f857079bccd633a54d1e6961a3f
https://doi.org/10.4155/fmc.14.118
https://doi.org/10.4155/fmc.14.118
Autor:
Erika, Nieddu, Benedetta, Pollarolo, Marco T, Mazzei, Maria, Anzaldi, Silvia, Schenone, Nicoletta, Pedemonte, Luis J V, Galietta, Mauro, Mazzei
The phenylhydrazone RDR-1 is endowed with moderate activity as F508del-CFTR corrector; nevertheless, its simple structure enables stimulating developments in this class of correctors. Therefore, we synthesized a number of phenylhydrazones 3 by reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9dd40c55159ffbeaba1a97368ee9c547
http://hdl.handle.net/11588/728871
http://hdl.handle.net/11588/728871