Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Benedetta, Artegiani"'
Autor:
Delilah Hendriks, Benedetta Artegiani, Thanasis Margaritis, Iris Zoutendijk, Susana Chuva de Sousa Lopes, Hans Clevers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mechanisms underlying human hepatocyte growth in development and regeneration are incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as organoids, while adult primary human hepatocyte (PHH) organoids remain
Externí odkaz:
https://doaj.org/article/2af830c56ec0454f8a7fc1b29bfbca34
Autor:
Anna Pagliaro, Roxy Finger, Iris Zoutendijk, Saskia Bunschuh, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain development in vitro. Typically, the fate of PSCs is guided into subsequent specification steps through static medium switches. In vivo, morphogen grad
Externí odkaz:
https://doaj.org/article/13e3eca99244404e9802541b35f6f911
Autor:
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited, partly due to the scarcity of experimental models. Here, w
Externí odkaz:
https://doaj.org/article/99e2cf8fc901400ca1ace1c5e4c2a58d
Autor:
Arif Ibrahim Ardisasmita, Imre F. Schene, Indi P. Joore, Gautam Kok, Delilah Hendriks, Benedetta Artegiani, Michal Mokry, Edward E. S. Nieuwenhuis, Sabine A. Fuchs
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
A systematic comparison of transcriptomes across different hepatocyte models provides a valuable resource to determine the most suitable model for a particular application or research question.
Externí odkaz:
https://doaj.org/article/403bc2d40d484beeaa9b734f875b3b5d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/072328ce38bb4374ad6a64d27feff035
Autor:
Gabriel Berdugo-Vega, Gonzalo Arias-Gil, Adrian López-Fernández, Benedetta Artegiani, Joanna M. Wasielewska, Chi-Chieh Lee, Michael T. Lippert, Gerd Kempermann, Kentaroh Takagaki, Federico Calegari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Ageing affects several brain areas causing a decrease in cognitive abilities and memory. We find that increasing the endogenous potential of the hippocampus to generate new neurons throughout life rejuvenates learning and memory, indicating that neur
Externí odkaz:
https://doaj.org/article/053faa42850e4fdca82723e9f3346693
Autor:
Benedetta Artegiani, Anna Lyubimova, Mauro Muraro, Johan H. van Es, Alexander van Oudenaarden, Hans Clevers
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3271-3284 (2017)
Adult neurogenesis in the murine dentate gyrus occurs in a specialized microenvironment that sustains the generation of neurons during life. To fully understand adult neurogenesis, it is essential to determine the neural stem cell (NSC) and progenito
Externí odkaz:
https://doaj.org/article/50a33083432e4594aa4097662ebc4179
Autor:
Delilah Hendriks, Jos F. Brouwers, Karien Hamer, Maarten H. Geurts, Léa Luciana, Simone Massalini, Carmen López-Iglesias, Peter J. Peters, Maria J. Rodríguez-Colman, Susana Chuva de Sousa Lopes, Benedetta Artegiani, Hans Clevers
Publikováno v:
Nature Biotechnology. Nature Publishing Group
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery and compound screening. Here we use human fetal hepatocyte organoids to model the first stage of NAFL
Publikováno v:
Genomics Data, Vol 7, Iss , Pp 264-268 (2016)
In recent years, DNA adenine methyltransferase identification (DamID) has emerged as a powerful tool to profile protein-DNA interaction on a genome-wide scale. While DamID has been primarily combined with microarray analyses, which limits the spatial
Externí odkaz:
https://doaj.org/article/633406701c8d4c26b4b167629c439722
Autor:
Gabriel Berdugo-Vega, Gonzalo Arias-Gil, Adrian López-Fernández, Benedetta Artegiani, Joanna M. Wasielewska, Chi-Chieh Lee, Michael T. Lippert, Gerd Kempermann, Kentaroh Takagaki, Federico Calegari
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8f64781251524094a613455cffc29489