Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study.

Autor: Werfel TA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Chemical Engineering, University of Mississippi, Oxford, Mississippi., Hicks DJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Rahman B; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Bendeman WE; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Duvernay MT; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Maeng JG; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Hamm H; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee., Lavieri RR; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Joly MM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Pulley JM; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, Tennessee., Elion DL; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Brantley-Sieders DM; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Cook RS; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee. rebecca.cook@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Breast Cancer Research Program, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.; Department of Biomedical Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2020 Dec; Vol. 19 (12), pp. 2454-2464. Date of Electronic Publication: 2020 Oct 08.