Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bence Szilágyi"'
Autor:
Bence Szilágyi, Csilla Hargitai, Ádám A. Kelemen, Anita Rácz, György G. Ferenczy, Balázs Volk, György M. Keserű
Publikováno v:
Molecules, Vol 24, Iss 2, p 290 (2019)
Most of the known inhibitors of D-amino acid oxidase (DAAO) are small polar molecules recognized by the active site of the enzyme. More recently a new class of DAAO inhibitors has been disclosed that interacts with loop 218−224 at the top of the bi
Externí odkaz:
https://doaj.org/article/f10f017070194c2ea5f460e388e6ab09
Autor:
György M. Keserű, Balázs Volk, Bence Szilágyi, Attila Egyed, István Mándity, Tamás Nagy, Katalin Kátai-Fadgyas
Publikováno v:
Synthesis. 55:959-966
A safe and metal-free process using ethyl glycinate hydrochloride as the starting material has been developed for the preparation of ethyl 5-acetyl-1H-pyrazole-3-carboxylate, a key intermediate for the synthesis of potential blockbuster drug substanc
Autor:
Zita Hegedűs, Péter Ábrányi-Balogh, Gergely Mészáros, Bence Szilágyi, Lucia Wittner, Ivan Ranđelović, Dénes Szepesi Kovács, József Tóvári, György M. Keserű, Imre Hajdu, Tímea Szabó, Domokos Meszéna, Estilla Zsófia Tóth, Mátyás Milen
Publikováno v:
RSC advances. 11(21)
The first representatives of the new fluorescent boro-β-carboline family were synthesized by the insertion of the difluoroboranyl group into the oxaza or diaza core. The resulting compounds showed good photophysical properties with fine Stokes-shift
Autor:
Katalin Monostory, Anita Rácz, Pál Szabó, István Vincze, Krisztina Németh, Júlia Visy, György G. Ferenczy, Éva Szökő, György T. Balogh, Tamás Tábi, György M. Keserű, Peter Kovacs, Janez Ilaš, Bence Szilágyi
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1579-1587
d-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain d-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and
Autor:
Dávid Bajusz, Zoltán Orgován, György G. Ferenczy, Bence Szilágyi, Thomas Steinbrecher, György M. Keserű
Publikováno v:
Journal of Computer-Aided Molecular Design. 32:331-345
Optimization of fragment size D-amino acid oxidase (DAAO) inhibitors was investigated using a combination of computational and experimental methods. Retrospective free energy perturbation (FEP) calculations were performed for benzo[d]isoxazole deriva
Autor:
Martina Gobec, Izidor Sosič, György G. Ferenczy, Stanislav Gobec, Matic Proj, Levente Kollár, Tímea Imre, György M. Keserű, László Petri, Damijan Knez, Bence Szilágyi, Péter Ábrányi-Balogh, Dávid Bajusz
Publikováno v:
European Journal of Medicinal Chemistry. 219:113455
Proteasomes contribute to maintaining protein homeostasis and their inhibition is beneficial in certain types of cancer and in autoimmune diseases. However, the inhibition of the proteasomes in healthy cells leads to unwanted side-effects and signifi
Publikováno v:
Expert opinion on drug discovery. 13(10)
D-amino-acid oxidase (DAAO) degrades D-serine, a co-agonist of the NMDA receptor whose dysfunction is involved in the positive, negative, and cognitive symptoms of schizophrenia. The inhibition of DAAO appears to be a viable strategy to increase D-se
Autor:
Csilla Hargitai, Anita Rácz, Bence Szilágyi, Balázs Volk, Ádám Andor Kelemen, György M. Keserű, György G. Ferenczy
Publikováno v:
Molecules
Volume 24
Issue 2
Molecules, Vol 24, Iss 2, p 290 (2019)
Volume 24
Issue 2
Molecules, Vol 24, Iss 2, p 290 (2019)
Most of the known inhibitors of D-amino acid oxidase (DAAO) are small polar molecules recognized by the active site of the enzyme. More recently a new class of DAAO inhibitors has been disclosed that interacts with loop 218−224 at the top of the bi
Autor:
Mária Polyák, Joseph Hayes, Pál Gergely, Gergely Varga, Jaida Begum, László Juhász, Bence Szilágyi, László Somsák, Tibor Docsa
Publikováno v:
Bioorganicmedicinal chemistry. 21(18)
All possible isomers of N-β-D-glucopyranosyl aryl-substituted oxadiazolecarboxamides were synthesised. O-Peracetylated N-cyanocarbonyl-β-D-glucopyranosylamine was transformed into the corresponding N-glucosyl tetrazole-5-carboxamide, which upon acy