Calcineurin promotes adaptation to chronic stress through two distinct mechanisms.

Autor: Flynn MJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605.; Interdisciplinary Graduate Program, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605., Harper NW; Interdisciplinary Graduate Program, Morningside Graduate School of Biomedical Sciences, University of Massachusetts Chan Medical School, Worcester, MA 01605.; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605., Li R; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605., Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605.; Department of Genomics and Computational Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605., Lee MJ; Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605., Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2024 Oct 01; Vol. 35 (10), pp. ar123. Date of Electronic Publication: 2024 Jul 31.

Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1.

Autor: Conti MM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Li R; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Narváez Ramos MA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Fazzio TG; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. jennifer.benanti@umassmed.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 19; Vol. 14 (1), pp. 310. Date of Electronic Publication: 2023 Jan 19.

Repression of essential cell cycle genes increases cellular fitness.

Autor: Conti MM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Ghizzoni JM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Gil-Bona A; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Wang W; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America., Costanzo M; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Li R; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Flynn MJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.; Program in Bioinformatics and Integrative Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America., Myers CL; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America., Boone C; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Andrews BJ; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2022 Aug 29; Vol. 18 (8), pp. e1010349. Date of Electronic Publication: 2022 Aug 29 (Print Publication: 2022).

Ubc1 turnover contributes to the spindle assembly checkpoint in Saccharomyces cerevisiae.

Autor: Arsenault HE; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Ghizzoni JM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Leech CM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Diers AR; BERG, Framingham, MA 01710, USA., Gesta S; BERG, Framingham, MA 01710, USA., Vishnudas VK; BERG, Framingham, MA 01710, USA., Narain NR; BERG, Framingham, MA 01710, USA., Sarangarajan R; BERG, Framingham, MA 01710, USA., Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Dec 08; Vol. 11 (12).

The coordinate actions of calcineurin and Hog1 mediate the stress response through multiple nodes of the cell cycle network.

Autor: Leech CM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Flynn MJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Arsenault HE; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Ou J; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Liu H; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.; Program in Bioinformatics and Integrative Biology, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America., Benanti JA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Apr 28; Vol. 16 (4), pp. e1008600. Date of Electronic Publication: 2020 Apr 28 (Print Publication: 2020).