Recruitment and remodeling of peridroplet mitochondria in human adipose tissue.

Autor: Acín-Perez R; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Petcherski A; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Veliova M; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA., Benador IY; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, 02118, USA., Assali EA; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Clinical Biochemistry, School of Medicine, Ben Gurion University of The Negev, Beer-Sheva, Israel., Colleluori G; Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, 60020, Italy., Cinti S; Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, 60020, Italy., Brownstein AJ; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Molecular Cellular Integrative Physiology, University of California, Los Angeles, CA, 90095, USA., Baghdasarian S; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Livhits MJ; Section of Endocrine Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Yeh MW; Section of Endocrine Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Krishnan KC; Department of Medicine, Division of Cardiology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, OH, USA., Vergnes L; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Winn NC; Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA; Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Padilla J; Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA., Liesa M; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA; Molecular Cellular Integrative Physiology, University of California, Los Angeles, CA, 90095, USA. Electronic address: mliesa@mednet.ucla.edu., Sacks HS; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Endocrine and Diabetes Division, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address: harold.sacks@va.org., Shirihai OS; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, 02118, USA; Molecular Cellular Integrative Physiology, University of California, Los Angeles, CA, 90095, USA. Electronic address: oshirihai@mednet.ucla.edu.

Publikováno v: Redox biology [Redox Biol] 2021 Oct; Vol. 46, pp. 102087. Date of Electronic Publication: 2021 Jul 30.

Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling.

Autor: Veliova M; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Ferreira CM; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Benador IY; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA., Jones AE; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Mahdaviani K; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA., Brownstein AJ; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Molecular Cellular Integrative Physiology, University of California, Los Angeles, CA, USA., Desousa BR; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Acín-Pérez R; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Petcherski A; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Assali EA; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Department of Clinical Biochemistry, School of Medicine, Ben Gurion University of The Negev, Beer-Sheva, Israel., Stiles L; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Divakaruni AS; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Prentki M; Department of Nutrition, , Université de Montréal, Montreal Diabetes Research Center and CRCHUM, Montréal, QC, Canada., Corkey BE; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA., Liesa M; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Oliveira MF; Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil., Shirihai OS; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA.

Publikováno v: EMBO reports [EMBO Rep] 2020 Dec 03; Vol. 21 (12), pp. e49634. Date of Electronic Publication: 2020 Dec 04.

A novel approach to measure mitochondrial respiration in frozen biological samples.

Autor: Acin-Perez R; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Benador IY; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA., Petcherski A; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Veliova M; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA., Benavides GA; Department of Pathology and Mitochondrial Medicine Laboratory, University of Alabama at Birmingham, Birmingham, AL, USA., Lagarrigue S; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Caudal A; Mitochondria and Metabolism Center, University of Washington, Seattle, WA, USA., Vergnes L; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Murphy AN; Department of Pharmacology, University of California, San Diego, CA, USA., Karamanlidis G; Cardiometabolic Disorders, Amgen Research, Thousand Oaks, CA, USA., Tian R; Mitochondria and Metabolism Center, University of Washington, Seattle, WA, USA., Reue K; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Wanagat J; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Medicine, Division of Geriatrics, University of California, Los Angeles, CA, USA., Sacks H; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Amati F; Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Darley-Usmar VM; Department of Pathology and Mitochondrial Medicine Laboratory, University of Alabama at Birmingham, Birmingham, AL, USA., Liesa M; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.; Molecular Biology Institute, UCLA, Los Angeles, CA, USA., Divakaruni AS; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA., Stiles L; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Shirihai OS; Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Metabolism Theme, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Nutrition and Metabolism, Graduate Medical Sciences, Boston University School of Medicine, Boston, MA, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA.; Molecular Biology Institute, UCLA, Los Angeles, CA, USA.

Publikováno v: The EMBO journal [EMBO J] 2020 Jul 01; Vol. 39 (13), pp. e104073. Date of Electronic Publication: 2020 May 20.

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion.

Autor: Benador IY; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Veliova M; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Mahdaviani K; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Petcherski A; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wikstrom JD; Dermatology and Venereology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Dermato-Venereology, Karolinska University Hospital, Stockholm, Sweden., Assali EA; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Clinical Biochemistry, School of Medicine, Ben Gurion University of The Negev, Beer-Sheva, Israel., Acín-Pérez R; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Shum M; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Oliveira MF; Institute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Cinti S; Department of Experimental and Clinical Medicine, University of Ancona, Ancona, Italy., Sztalryd C; Department of Medicine, School of Medicine, University of Maryland Baltimore, MD, USA., Barshop WD; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Wohlschlegel JA; Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Corkey BE; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Liesa M; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: mliesa@mednet.ucla.edu., Shirihai OS; Division of Endocrinology, Department of Medicine, and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Clinical Biochemistry, School of Medicine, Ben Gurion University of The Negev, Beer-Sheva, Israel. Electronic address: oshirihai@mednet.ucla.edu.

Publikováno v: Cell metabolism [Cell Metab] 2018 Apr 03; Vol. 27 (4), pp. 869-885.e6.

The rat with oxygen-induced retinopathy is myopic with low retinal dopamine.

Autor: Zhang N; Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts., Favazza TL, Baglieri AM, Benador IY, Noonan ER, Fulton AB, Hansen RM, Iuvone PM, Akula JD

Publikováno v: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2013 Dec 19; Vol. 54 (13), pp. 8275-84. Date of Electronic Publication: 2013 Dec 19.