Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ben-gang You"'
Autor:
Wen-jun Wan, Ben-gang You, Xue-nong Zhang, Yu Wang, Meng-tian Chen, Ye-juan Zhou, Yao Tong, Yang Liu, Dan-dan Wang
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:1710-1724
Cancer cells have been reported to exhibit high resistance against immune system recognition through various cell intrinsic and extrinsic mechanisms. Considerable challenges have been encountered in monotherapy with chemotherapeutics to attain the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6085068fc811a94d05c1d93bb67079a3
https://doi.org/10.1002/jbm.b.34516
https://doi.org/10.1002/jbm.b.34516
Autor:
Wei-liang Chen, Chen-xi Qu, Xue-nong Zhang, Yang Liu, Dan-dan Wang, Meng-tian Chen, Yu Wang, Ye-juan Zhou, Fang Li, Ben-gang You, Shu-di Yang
Publikováno v:
Theranostics
Targeting tumor angiogenesis pathway via VEGF siRNA (siVEGF) has shown great potential in treating highly malignant and metastatic non-small cell lung cancer (NSCLC). However, anti-angiogenic monotherapy lacked sufficient antitumor efficacy which suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6030a4656780654df8a20f7dd9ebe14a
http://europepmc.org/articles/PMC6735374
http://europepmc.org/articles/PMC6735374
Autor:
Ye-juan Zhou, Wen-jun Wan, Ben-gang You, Xue-nong Zhang, Chen-xi Qu, Fang Li, Liang Zhang, Meng-tian Chen, Yang Liu, Dan-dan Wang
Publikováno v:
International Journal of Pharmaceutics. 566:731-744
Tumor cells avoid immunosurveillance during the tumorigenesis, metastasis and recurrence periods thanks to the overexpressed immunosuppressive molecules on their surface. For instance, the programmed cell death 1 ligand (PD-L1) binds with the T-cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403c0098062bccf952f4b1b9fdad64db
https://doi.org/10.1016/j.ijpharm.2019.06.030
https://doi.org/10.1016/j.ijpharm.2019.06.030
Autor:
Ying Wang, Yang Liu, Ben-gang You, Chen-xi Qu, Wei-liang Chen, Meng-tian Chen, Xue-nong Zhang, Zhaoxiang Ren, Shu-di Yang
Publikováno v:
Molecular Pharmaceutics. 15:314-325
In this article, a novel graft polymeric micelle with targeting function ground on aptamer AS1411 was synthesized. The micelle was based on chitosan-ss-polyethylenimine-urocanic acid (CPU) with dual pH/redox sensitivity and targeting effects. This mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568cd791d69a2a12301cdf676676b256
https://doi.org/10.1021/acs.molpharmaceut.7b01093
https://doi.org/10.1021/acs.molpharmaceut.7b01093
Publikováno v:
Materials Science and Engineering: C. 119:111583
Acute myeloid leukemia (AML) is the most universal type and fatal disease of hematological malignancy, with poor outcomes despite chemotherapy and bone marrow transplantations. Benefited from the narrow tissue specificity of folate receptor β (FRβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c327d9d14fd48ba4b6759dc77ae8f66c
https://doi.org/10.1016/j.msec.2020.111583
https://doi.org/10.1016/j.msec.2020.111583
Autor:
Shu-di Yang, Ben-gang You, Xue-nong Zhang, Ji-zhao Li, Chun-ge Zhang, Chun Liu, Zhi-qiang Yuan, Wen-jing Zhu, Wei-liang Chen, Xiao-feng Zhou, Yang Liu
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 105:2093-2106
P-glycoprotein (P-gp) plays an importantrole in multidrug resistance (MDR), proved to be one of the major obstacles in cancer chemotherapy. Cationic polymers could specifically deliver siRNA to tumor cells and thus reverse MDR by the downregulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efae23f99861abd13d8a063b5f1b42f0
https://doi.org/10.1002/jbm.b.33748
https://doi.org/10.1002/jbm.b.33748
Autor:
Gui Huang, Ye-juan Zhou, Yu Wang, Hui Li, Wei-liang Chen, Wen-jun Wan, Yang Liu, Ben-gang You, Xue-nong Zhang, Dan-dan Wang
Publikováno v:
International Journal of Pharmaceutics. 585:119456
How to overcome the cell membrane barriers and achieve release payloads efficiently in the cytoplasm have been major challenges for anticancer drug delivery and therapeutic effects with nanosystems. In this study, bovine serum albumin (BSA) was modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38c6b06c38d4de0ccae427e5ba0b9be
https://doi.org/10.1016/j.ijpharm.2020.119456
https://doi.org/10.1016/j.ijpharm.2020.119456
Autor:
Fang Li, Chen-xi Qu, Shu-di Yang, Wei-liang Chen, Xue-nong Zhang, Yang Liu, Ben-gang You, Ji-zhao Li, Zhi-qiang Yuan, Ye-juan Zhou
Publikováno v:
ACS applied materialsinterfaces. 10(43)
Drug development involves various evaluation processes to ascertain drug effects and rigorous analysis of biological indicators during in vitro preclinical studies. Two-dimensional (2D) cell cultures are commonly used in numerous in vitro studies, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfea8e31bc2d09551b3d0a0d3b0c446
https://pubmed.ncbi.nlm.nih.gov/30360129
https://pubmed.ncbi.nlm.nih.gov/30360129
Autor:
Ben-gang You, Xue-nong Zhang, Fang Li, Ye-juan Zhou, Ji-zhao Li, Chen-xi Qu, Shu-di Yang, Yang Liu, Wei-liang Chen
Publikováno v:
The AAPS journal. 20(2)
Low accumulation in tumor sites and slow intracellular drug release remain as the obstacles for nanoparticles to achieve effective delivery of chemotherapeutic drugs. In this study, multifunctional micelles were designed to deliver doxorubicin (Dox)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be21ba6fd7dd2f308b9eeb8783673f37
https://pubmed.ncbi.nlm.nih.gov/29476273
https://pubmed.ncbi.nlm.nih.gov/29476273
Autor:
Yang Liu, Ben-gang You, Wen-jing Zhu, Qiao-Ling Zhu, Chen-xi Qu, Zhi-qiang Yuan, Shu-di Yang, Fang Li, Xue-nong Zhang, Wei-liang Chen
Publikováno v:
International Journal of Nanomedicine
Wen-jing Zhu,1,* Shu-di Yang,1,* Chen-xi Qu,1 Qiao-ling Zhu,1,2 Wei-liang Chen,1 Fang Li,1 Zhi-qiang Yuan,1 Yang Liu,1 Ben-gang You,1 Xue-nong Zhang1 1Department of Pharmaceutics, College of Pharmaceutical Sciences, Soochow University, Suzhou, 2Depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8e6ed239da07c74fa00e6ba324a2fe
https://www.dovepress.com/low-density-lipoprotein-coupled-micelles-with-reduction-and-ph-dual-se-peer-reviewed-article-IJN
https://www.dovepress.com/low-density-lipoprotein-coupled-micelles-with-reduction-and-ph-dual-se-peer-reviewed-article-IJN