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Autor:
Enrique Gonzales, Wen Wei, Chiranjib Dasgupta, Ben-Xian Liu, Daniel Broek, Peng Li, Denise M. McKinney, Pritha Sanyal, Raymond D. Mosteller
Publikováno v:
Proceedings of the National Academy of Sciences. 89:7100-7104
The yeast Saccharomyces cerevisiae CDC25 gene encodes a nucleotide-exchange-factor (NEF) that can convert the inactive GDP-bound state of RAS proteins to an active RAS-GTP complex. CDC25 can activate the yeast RAS proteins as well as the human H-ras