Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ben van Ravenzwaay"'
Autor:
Abdulkarim Najjar, Ans Punt, John Wambaugh, Alicia Paini, Corie Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis Mueller, Hequn Li, Quan Shi, Timothy W. Gant, Phil Botham, Rémi Bars, Aldert Piersma, Ben van Ravenzwaay, Nynke I. Kramer
Publikováno v:
Archives of Toxicology 96 (2022) 12
Archives of Toxicology, 96(12), 3407-3419
Archives of Toxicology, 96(12), 3407-3419
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes
Autor:
Carole L. Yauk, Brian N. Chorley, Timothy W. Gant, Stefania Perdichizzi, Alan Poole, Knut E. Tollefsen, Weida Tong, Jörg Hackermüller, Shu-Dong Zhang, Ben van Ravenzwaay, Ursula G. Sauer
Publikováno v:
Regulatory Toxicology and Pharmacology. 91:S36-S45
A generic Transcriptomics Reporting Framework (TRF) is presented that lists parameters that should be reported in ‘omics studies used in a regulatory context. The TRF encompasses the processes from transcriptome profiling from data generation to a
Autor:
Tewes Tralau, Roland Buesen, Jim Bridges, Mark Pemberton, Ben van Ravenzwaay, Alan Poole, Lize Deferme, Ursula G. Sauer, Knut E. Tollefsen
Publikováno v:
Regulatory Toxicology and Pharmacology. 91:S46-S60
A framework for the quantitative weight-of-evidence (QWoE) analysis of 'omics data for regulatory purposes is presented. The QWoE framework encompasses seven steps to evaluate 'omics data (also together with non-'omics data): (1) Hypothesis formulati
Autor:
Alberto Mantovani, Tanja Waldmann, Bob van de Water, Cristina Cadenas, Hennicke Kamp, Thomas Braunbeck, Annemarie H. Meijer, Mathieu Vinken, Sylvia Escher, Domenico Gadaleta, Patricio Godoy, Anna Forsby, Stefan Schildknecht, Chris T. Evelo, Stefan Höhme, Rosemarie Marchan, Gerhard F. Ecker, Harry Vrieling, Susanne Hougaard Bennekou, Ciarán Fisher, Alice Limonciel, Enrico Mombelli, Rabea Graepel, Marcel Leist, Ahmed Ghallab, Michael Schwarz, Joost B. Beltman, Jens M. Kelm, Albert Braeuning, Olivier Taboureau, Bart van der Burg, Andrea Terron, Ferran Sanz, Frédéric Y. Bois, Steven Dooley, Dinant Kroese, Jan G. Hengstler, Paul Jennings, Egon Willighagen, Barbara Zdrazil, Barry Hardy, Erik H.J. Danen, Bjørn E. V. Koch, David A. Fluri, Christoph van Thriel, Dirk Drasdo, Ben van Ravenzwaay, Iain Gardner, Franz Oesch, Reham Hassan, Raymond Reif, Marvin Martens, Thomas Hartung
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3
Archives of Toxicology, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, Springer Verlag, 2017, 91 (11), pp.3477-3505. ⟨10.1007/s00204-017-2045-3⟩
Archives of Toxicology, 91(11), 3477-3505. Springer Verlag
Archives of Toxicology, 91(11), 3477-3505
Archives of Toxicology, 91(11), 3477-3505. Springer
Archives of Toxicology, 11, 91, 3477-3505
Leist, M, Ghallab, A, Graepel, R, Marchan, R, Hassan, R, Bennekou, S H, Limonciel, A, Vinken, M, Schildknecht, S, Waldmann, T, Danen, E H J, van Ravenzwaay, B, Kamp, H, Gardner, I, Godoy, P, Bois, F Y, Braeuning, A, Reif, R, Oesch, F, Drasdo, D, Höhme, S, Schwarz, M, Hartung, T, Braunbeck, T, Beltman, J, Vrieling, H, Sanz, F, Forsby, A, Gadaleta, D, Fisher, C, Kelm, J, Fluri, D, Ecker, G F, Zdrazil, B, Terron, A, Jennings, P, van der Burg, B, Dooley, S, Meijer, A H, Willighagen, E, Martens, M, Evelo, C T, Mombelli, E, Taboureau, O, Mantovani, A, Hardy, B, Koch, B, Escher, S, van Thriel, C, Cadenas, C, Kroese, D, van de Water, B & Hengstler, J G 2017, ' Adverse outcome pathways : opportunities, limitations and open questions ', Archives of Toxicology, vol. 91, no. 11, pp. 3477-3505 . https://doi.org/10.1007/s00204-017-2045-3
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (
Autor:
Tewes Tralau, Regine Fuchs, Knut E. Tollefsen, Hennicke Kamp, Ben van Ravenzwaay, Jörg Hackermüller, Stefania Perdichizzi, Hans-Martin Kauffmann, Timothy M. D. Ebbels, Carole L. Yauk, Ursula G. Sauer, Lize Deferme, Brian N. Chorley, Alan Poole
Publikováno v:
S35
S27
S27
‘Omics technologies are gaining importance to support regulatory toxicity studies. Prerequisites for performing ‘omics studies considering GLP principles were discussed at the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3533e927ebc27a7dc84ffc4b04b33764
http://hdl.handle.net/10044/1/56974
http://hdl.handle.net/10044/1/56974
Publikováno v:
Toxicology in Vitro. 29(1):113-123
Skin absorption testing in vitro is a regulatory accepted alternative method (OECD Guideline 428). Different tests can be applied to evaluate the integrity of the skin samples. Here, we compared the pre- or post-run integrity tests (transepidermal el
Autor:
Ben van Ravenzwaay, Jörg Hackermüller, Alan Poole, Ursula G. Sauer, Laura Gribaldo, Timothy W. Gant, Lize Deferme, Carole L. Yauk, Tewes Tralau, Weida Tong
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 91
This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that 'omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard assessment. While they are
Autor:
Ben van Ravenzwaay, Tzutzuy Ramirez, Tilmann B. Walk, Werner Mellert, Hennicke Kamp, Thomas Hofmann, Erik Peter, Hans Albrecht Huener, Xiaoqi Jiang, Thomas Hartung, Alexander Strigun, Michael Manfred Herold, A. Verlohner, Michael Spitzer, Natalie Bordag, Saskia Sperber
Publikováno v:
Archives of Toxicology
Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal welfare, in vitro techniques facilitate exploring and unders
Autor:
Lan Ma-Hock, Hans-Juergen Haussmann, Karin Wiench, Martin Kayser, Robert Landsiedel, Ben van Ravenzwaay
Publikováno v:
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 4:399-413
While technical and medical potential offered by nanotechnologies increase, the safety assessment of engineered nanomaterials (NMs) needs to follow this pace. Inhalation is a major route of occupational and environmental exposure, and is most relevan
Autor:
Franz Oesch, Eric Fabian, Wendel Wohlleben, Robert Landsiedel, Lan Ma-Hock, Karin Wiench, Ben van Ravenzwaay
Publikováno v:
Archives of Toxicology. 86:1021-1060
Nanomaterials (NM) offer great technological advantages but their risks to human health are still under discussion. For toxicological testing and evaluation, information on the toxicokinetics of NM is essential as it is different from that of most ot