Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ben Zweifel"'
Publikováno v:
Journal of Receptors and Signal Transduction. 41:425-433
To compare the binding and agonistic activity of ActharActhar Gel and synthetic MCR agonists exhibited the highest binding at MC1R, lowest binding at MC5R, and moderate binding at MC3R and MC4R. Acthar Gel stimulated the production of cAMP in all 5 M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a163c2c226e01fc725b6bc37e3f1a
https://doi.org/10.1080/10799893.2020.1818094
https://doi.org/10.1080/10799893.2020.1818094
Publikováno v:
Abstracts Accepted for Publication.
Background: Melanocortin receptor agonists, such as αMSH have been shown to reduce inflammation in preclinical models, suppressing the production of proinflammatory cytokines. Natural and synthetic ACTH analogues remain linked to the induction of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45dd480795558b3d9022c0ad584ae27f
https://doi.org/10.1136/annrheumdis-2019-eular.4127
https://doi.org/10.1136/annrheumdis-2019-eular.4127
Publikováno v:
The Journal of Immunology. 198:127.9-127.9
Repository corticotropin injection (RCI: H.P. Acthar® gel) contains a purified porcine pituitary ACTH-analogue, and is an FDA-approved treatment for several inflammatory eye diseases. ACTH binds to all 5 known melanocortin receptors and may suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359d9b565fbcabf20d0762ad57ddaeef
https://doi.org/10.4049/jimmunol.198.supp.127.9
https://doi.org/10.4049/jimmunol.198.supp.127.9