Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy

Autor: Zaid Taha, Mathieu Joseph François Crupi, Nouf Alluqmani, Duncan MacKenzie, Sydney Vallati, Jack Timothy Whelan, Faiha Fareez, Akram Alwithenani, Julia Petryk, Andrew Chen, Marcus Mathew Spinelli, Kristy Ng, Judy Sobh, Christiano Tanese de Souza, Priya Rose Bharadwa, Timothy Kit Hin Lee, Dylan Anthony Thomas, Ben Zhen Huang, Omar Kassas, Joanna Poutou, Victoria Heather Gilchrist, Stephen Boulton, Max Thomson, Ricardo Marius, Mohsen Hooshyar, Scott McComb, Rozanne Arulanandam, Carolina Solange Ilkow, John Cameron Bell, Jean-Simon Diallo

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Targeted antineoplastic immunotherapies have achieved remarkable clinical outcomes. However, resistance to these therapies due to target absence or antigen shedding limits their efficacy and excludes tumours from candidacy. To address this l

Externí odkaz: https://doaj.org/article/f45d398fc89f455a93faf9739ef489c7

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development

Autor: Stephen Boulton, Mathieu J.F. Crupi, Siddharth Singh, Madalina E. Carter-Timofte, Taha Azad, Bailey C. Organ, Xiaohong He, Rida Gill, Serge Neault, Taylor Jamieson, Jaahnavi Dave, Naziia Kurmasheva, Bradley Austin, Julia Petryk, Ragunath Singaravelu, Ben Zhen Huang, Noah Franco, Kaaviya Babu, Robin J. Parks, Carolina S. Ilkow, David Olagnier, John C. Bell

Publikováno v: Boulton, S, Crupi, M J F, Singh, S, Carter-Timofte, M E, Azad, T, Organ, B C, He, X, Gill, R, Neault, S, Jamieson, T, Dave, J, Kurmasheva, N, Austin, B, Petryk, J, Singaravelu, R, Huang, B Z, Franco, N, Babu, K, Parks, R J, Ilkow, C S, Olagnier, D & Bell, J C 2023, ' Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development ', The Journal of Biological Chemistry, vol. 299, no. 6, 104749 . https://doi.org/10.1016/j.jbc.2023.104749

The recent SARS-CoV-2 and mpox outbreaks have highlighted the need to expand our arsenal of broad-spectrum antiviral agents for future pandemic preparedness. Host-directed antivirals are an important tool to accomplish this as they typically offer pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b32745bd6947ccc21790ccd5e16728a
https://pure.au.dk/portal/da/publications/inhibition-of-exchange-proteins-directly-activated-by-camp-as-a-strategy-for-broadspectrum-antiviral-development(6acf2940-262b-421c-9f4c-6c2678322a6a).html

Inhibition of exchange proteins directly activated by cAMP as a strategy for broad-spectrum antiviral development.

Autor: Boulton, Stephen^1,2 sboulton@ohri.ca, Crupi, Mathieu J. F.^1,2, Singh, Siddharth^1,2, Carter-Timofte, Madalina E.³, Azad, Taha^1,2,4,5, Organ, Bailey C.^1,2, Xiaohong He^1,2, Gill, Rida^1,2, Neault, Serge^1,2, Jamieson, Taylor^1,2, Dave, Jaahnavi^1,2, Kurmasheva, Naziia³, Austin, Bradley¹, Petryk, Julia¹, Singaravelu, Ragunath^1,2,6, Ben Zhen Huang^1,2, Franco, Noah^1,2, Babu, Kaaviya^1,2, Parks, Robin J.^1,2,7, Ilkow, Carolina S.^1,2

Publikováno v: Journal of Biological Chemistry. Jun2023, Vol. 299 Issue 6, p1-17. 17p.