Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Ben Z Stanger"'
Autor:
Yogev Sela, Jinyang Li, Paola Kuri, Allyson J Merrell, Ning Li, Chris Lengner, Pantelis Rompolas, Ben Z Stanger
Publikováno v:
eLife, Vol 10 (2021)
Cancer patients often harbor occult metastases, a potential source of relapse that is targetable only through systemic therapy. Studies of this occult fraction have been limited by a lack of tools with which to isolate discrete cells on spatial groun
Externí odkaz:
https://doaj.org/article/f4a63f76da2243cd878f4a9f62eef605
Autor:
Caitlin M Braitsch, D Berfin Azizoglu, Yadanar Htike, Haley R Barlow, Ulrike Schnell, Christopher P Chaney, Thomas J Carroll, Ben Z Stanger, Ondine Cleaver
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000382 (2019)
The Hippo pathway directs cell differentiation during organogenesis, in part by restricting proliferation. How Hippo signaling maintains a proliferation-differentiation balance in developing tissues via distinct molecular targets is only beginning to
Externí odkaz:
https://doaj.org/article/8326948c95cd4ccdb08daf2675630906
Autor:
Christopher A Natale, Jinyang Li, Junqian Zhang, Ankit Dahal, Tzvete Dentchev, Ben Z Stanger, Todd W Ridky
Publikováno v:
eLife, Vol 7 (2018)
Female sex and history of prior pregnancies are associated with favorable melanoma outcomes. Here, we show that much of the melanoma protective effect likely results from estrogen signaling through the G protein-coupled estrogen receptor (GPER) on me
Externí odkaz:
https://doaj.org/article/bb911bbd34eb401e861e22994ff670ef
Autor:
Benjamin Assouline, Rachel Kahn, Lutfi Hodali, Reba Condiotti, Yarden Engel, Ela Elyada, Tzlil Mordechai-Heyn, Jason R. Pitarresi, Dikla Atias, Eliana Steinberg, Tirza Bidany-Mizrahi, Esther Forkosh, Lior H. Katz, Ofra Benny, Talia Golan, Matan Hofree, Sheila A. Stewart, Karine A. Atlan, Gideon Zamir, Ben Z. Stanger, Michael Berger, Ittai Ben-Porath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions. However, the identities and traits of these cells, and the potential for improving cancer therapy through their targeting, remain poorly charac
Externí odkaz:
https://doaj.org/article/3aed130938ea4e87851508070eec5837
Autor:
Zhewei Shen, Ben Z Stanger
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117522 (2015)
The Hippo pathway regulates cell proliferation and apoptosis through the Yes-associated protein (YAP) transcriptional activator. YAP has a well-described role in promoting cell proliferation and survival, but the precise mechanisms and transcriptiona
Externí odkaz:
https://doaj.org/article/1c103ba04ca5412eac9cbab83816fdca
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132437 (2015)
Cell competition is a form of cell-cell interaction by which cells compare relative levels of fitness, resulting in the active elimination of less-fit cells, "losers," by more-fit cells, "winners." Here, we show that in three routinely-used mammalian
Externí odkaz:
https://doaj.org/article/60f0258ac87740b894524cd11be69d15
Autor:
Takeshi Katsuda, Jonathan H. Sussman, Kenji Ito, Andrew Katznelson, Salina Yuan, Naomi Takenaka, Jinyang Li, Allyson J. Merrell, Hector Cure, Qinglan Li, Reyaz Ur Rasool, Irfan A. Asangani, Kenneth S. Zaret, Ben Z. Stanger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors
Externí odkaz:
https://doaj.org/article/b2c5a3c430084dd3bae1dbe3580360ff
Autor:
Il-Kyu Kim, Mark S. Diamond, Salina Yuan, Samantha B. Kemp, Benjamin M. Kahn, Qinglan Li, Jeffrey H. Lin, Jinyang Li, Robert J. Norgard, Stacy K. Thomas, Maria Merolle, Takeshi Katsuda, John W. Tobias, Timour Baslan, Katerina Politi, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Acquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses,
Externí odkaz:
https://doaj.org/article/96e408eb89f447649478a14b903b0f6a
Autor:
Rena Zheng, Boris Rebolledo-Jaramillo, Yiwei Zong, Liqing Wang, Pierre Russo, Wayne Hancock, Ben Z Stanger, Ross C Hardison, Gerd A Blobel
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83723 (2013)
GATA transcription factors and their Friend of Gata (FOG) cofactors control the development of diverse tissues. GATA4 and GATA6 are essential for the expansion of the embryonic liver bud, but their expression patterns and functions in the adult liver
Externí odkaz:
https://doaj.org/article/cc1b818cb1d9408b9cafd0956bb7a359
Autor:
Ning Li, Qin Zhu, Yuhua Tian, Kyung Jin Ahn, Xin Wang, Zvi Cramer, Justine Jou, Ian W. Folkert, Pengfei Yu, Stephanie Adams-Tzivelekidis, Priyanka Sehgal, Najia N. Mahmoud, Cary B. Aarons, Robert E. Roses, Andrei Thomas-Tikhonenko, Emma E. Furth, Ben Z. Stanger, Anil Rustgi, Malay Haldar, Bryson W. Katona, Kai Tan, Christopher J. Lengner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenv
Externí odkaz:
https://doaj.org/article/27a70ad4c8a74c5881020e751a7a5388