Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ben Wilenkin"'
Autor:
David J Matson, Darryl T Hamamoto, Howard Bregman, Melanie Cooke, Erin F DiMauro, Liyue Huang, Danielle Johnson, Xingwen Li, Jeff McDermott, Carrie Morgan, Ben Wilenkin, Annika B Malmberg, Stefan I McDonough, Donald A Simone
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138140 (2015)
While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological N
Externí odkaz:
https://doaj.org/article/0837a210c9304876b8143a23aa472839
Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves
Autor:
Ben Wilenkin, Eric Nisenbaum, Fei Ru, Mònica Aparici, Baolin Li, R. Adam Herbstsomer, Jeffrey L. Krajewski, Montserrat Miralpeix, Michaela Kocmalova, Silvia Fonquerna, Sonya Meeker, Jeff McDermott, Bradley J. Undem, Xian Xuan Chi, Marian Kollarik, Brendan J. Canning
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(1)
Little is known about the neuronal voltage-gated sodium channels (NaVs) that control neurotransmission in the parasympathetic nervous system. We evaluated the expression of the α subunits of each of the nine NaVs in human, guinea pig, and mouse airw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2923ae10482661473884189700bc74b6
https://pubmed.ncbi.nlm.nih.gov/28138042
https://pubmed.ncbi.nlm.nih.gov/28138042
Autor:
Dong Liu, Xingwen Li, Hanh Nho Nguyen, Jeff S. McDermott, Stefan I. McDonough, Erin F. DiMauro, Liyue Huang, Anruo Zou, Elma Feric, Joseph Ligutti, Ben Wilenkin, Howard Bregman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2033-2042
Herein the discovery of a novel class of aminoheterocyclic Na(v)1.7 antagonists is reported. Hit compound 1 was potent but suffered from poor pharmacokinetics and selectivity. The compact structure of 1 offered a modular synthetic strategy towards a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9eee5de2f610f6e84172c5fe82a3589
https://doi.org/10.1016/j.bmcl.2012.01.023
https://doi.org/10.1016/j.bmcl.2012.01.023
Autor:
Elma Feric, Dong Liu, Joseph Ligutti, Liyue Huang, Hanh Nho Nguyen, Anruo Zou, John L. Buchanan, Jeff S. McDermott, Ben Wilenkin, Howie Bregman, David J. Matson, Bingfan Du, Annika B. Malmberg, Xingwen Li, Vinod F. Patel, Stefan I. McDonough, Erin F. DiMauro
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
Clinical genetic data have shown that the product of the SCN9A gene, voltage-gated sodium ion channel Nav1.7, is a key control point for pain perception and a possible target for a next generation of analgesics. Sodium channels, however, historically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471c64db91100bebeeedfbb41dafcef4
https://pubmed.ncbi.nlm.nih.gov/22209205
https://pubmed.ncbi.nlm.nih.gov/22209205
Autor:
Brett Janosky, April Chen, Elma Feric, John L. Buchanan, Xingwen Li, Peter Miu, Joseph Ligutti, Liyue Huang, Jeff S. McDermott, Markus Hierl, David C. Immke, David J. Matson, Stefan I. McDonough, Annika B. Malmberg, Dong Liu, Anruo Zou, Erin F. DiMauro, Bingfan Du, Xiao Mei Zheng, Hanh Nho Nguyen, Loren Berry, Vinod F. Patel, Daniel Waldon, Ben Wilenkin, Howard Bregman, Danielle Johnson
Publikováno v:
Journal of medicinal chemistry. 54(13)
Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0554d821ede56752ff72b8f427a167f
https://pubmed.ncbi.nlm.nih.gov/21634377
https://pubmed.ncbi.nlm.nih.gov/21634377