Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ben W. Blue"'
Autor:
Joseph D. Janizek, Anna Spiro, Safiye Celik, Ben W. Blue, John C. Russell, Ting-I Lee, Matt Kaeberlin, Su-In Lee
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)
Abstract As interest in using unsupervised deep learning models to analyze gene expression data has grown, an increasing number of methods have been developed to make these models more interpretable. These methods can be separated into two groups: po
Externí odkaz:
https://doaj.org/article/e28d031d40c24e3483d38d0e92b91ca7
Autor:
Matthew M. Crane, Mitsuhiro Tsuchiya, Ben W. Blue, Jared D. Almazan, Kenneth L. Chen, Siobhan R. Duffy, Alexandra Golubeva, Annaiz M. Grimm, Alison M. Guard, Shauna A. Hill, Ellen Huynh, Ryan M. Kelly, Michael Kiflezghi, Hyunsung D. Kim, Mitchell Lee, Ting-I. Lee, Jiayi Li, Bao M.G. Nguyen, Riley M. Whalen, Feng Y. Yeh, Mark McCormick, Brian K. Kennedy, Joe R. Delaney, Matt Kaeberlein
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss , Pp 104-108 (2019)
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicati
Externí odkaz:
https://doaj.org/article/c89ce9517266486f955ce79743486c70
Autor:
Naci Oz, Elena Vayndorf, Mitsuhiro Tsuchiya, Samantha McLean, Lesly Turcios-Hernandez, Jason N. Pitt, Ben W. Blue, Michael Muir, Michael G. Kiflezghi, Alexander Tyshkovskiy, Alexander Mendenhall, Matt Kaeberlein, Alaattin Kaya
Publikováno v:
GeroScience. 44:1995-2006
At the cellular level, many aspects of aging are conserved across species. This has been demonstrated by numerous studies in simple model organisms like Saccharomyces cerevisiae, Caenorhabdits elegans, and Drosophila melanogaster. Because most geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faeabfc061af5d3ce6682c958ec6a109
https://doi.org/10.1007/s11357-022-00604-5
https://doi.org/10.1007/s11357-022-00604-5
Autor:
Matthew M Crane, Adam E Russell, Brent J Schafer, Ben W Blue, Riley Whalen, Jared Almazan, Mung Gi Hong, Bao Nguyen, Joslyn E Goings, Kenneth L Chen, Ryan Kelly, Matt Kaeberlein
Publikováno v:
eLife, Vol 8 (2019)
Genome instability is a hallmark of aging and contributes to age-related disorders such as cancer and Alzheimer’s disease. The accumulation of DNA damage during aging has been linked to altered cell cycle dynamics and the failure of cell cycle chec
Externí odkaz:
https://doaj.org/article/bdc8a0476fd94e2ea008c1539e8f5cce
Autor:
Joseph D. Janizek, Anna Spiro, Safiye Celik, Ben W. Blue, Josh C. Russell, Ting-I Lee, Matt Kaeberlin, Su-In Lee
As interest in unsupervised deep learning models for the analysis of gene expression data has grown, an increasing number of methods have been developed to make these deep learning models more interpretable. These methods can be separated into two gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3450547f1c9a66466ca1c9fe69766bf2
https://doi.org/10.1101/2022.05.03.490535
https://doi.org/10.1101/2022.05.03.490535
Autor:
Hyunsung D. Kim, Michael G. Kiflezghi, Ting-I Lee, Ryan M. Kelly, Jared Almazan, Mitchell B. Lee, Siobhan R. Duffy, Shauna A. Hill, Riley Whalen, Feng Y. Yeh, Ellen Huynh, Mitsuhiro Tsuchiya, Bao M.G. Nguyen, Ken Chen, Brian K. Kennedy, Annaiz M. Grimm, Matt Kaeberlein, Joe R. Delaney, Mark A. McCormick, Matthew M. Crane, Ben W. Blue, Jiayi Li, Alison M. Guard, Alexandra Golubeva
Publikováno v:
Translational Medicine of Aging, Vol 3, Iss, Pp 104-108 (2019)
An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1477126f5f4ebb210b46df7d14b05
http://www.sciencedirect.com/science/article/pii/S2468501119300380
http://www.sciencedirect.com/science/article/pii/S2468501119300380
Autor:
Ryan P. Kelly, Matthew M. Crane, Bao Nguyen, Joslyn E Goings, Matt Kaeberlein, Jared Almazan, Ken Chen, Ben W. Blue, Mung Gi Hong, Riley Whalen, Adam E Russell, Brent J Schafer
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Genome instability is a hallmark of aging and contributes to age-related disorders such as cancer and Alzheimer’s disease. The accumulation of DNA damage during aging has been linked to altered cell cycle dynamics and the failure of cell cycle chec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5946abe26dff55603bd1b44afead0f9a
https://elifesciences.org/articles/50778
https://elifesciences.org/articles/50778
Autor:
Mung Gi Hong, Ben W. Blue, Bao Nguyen, Ryan P. Kelly, Joslyn E Goings, Ken Chen, Matt Kaeberlein, Matthew M. Crane, Jared Almazan, Riley Whalen, Adam E Russell, Brent J Schafer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e97d950b2cffd0cd0fc4648075e9b9e
https://doi.org/10.7554/elife.50778.032
https://doi.org/10.7554/elife.50778.032
Publikováno v:
Proteomics
All organisms age, but the extent to which all organisms age the same way remains a fundamental unanswered question in biology. Across species, it is now clear that at least some aspects of aging are highly conserved and are perhaps universal, but ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1e6e3718061e9084d24b30ab3c5a7f
https://pubmed.ncbi.nlm.nih.gov/31385433
https://pubmed.ncbi.nlm.nih.gov/31385433
Publikováno v:
Innovation in Aging
Over the past decade, the identification of potential genetic and pharmacological modifiers of lifespan and age-related pathologies in C. elegans and other model organisms has yielded fruitful leads for follow-up investigation. A major limitation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293336a10b73912b579f7567a2049bc4
http://europepmc.org/articles/PMC6846426
http://europepmc.org/articles/PMC6846426