Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ben Umiker"'
Autor:
Ben Umiker, Yasmin Hashambhoy-Ramsay, Jeff Smith, Tanzila Rahman, Amy Mueller, Rachel Davidson, Christina Meyer, Gayatri Patankar, Mohammad Murshid Alam, Sarah Jaffe, Kristin Krukenberg, Allison Goodman, Vikki Spaulding, Michelle Priess, Abha Dhaneshwar, Masie Wong, Alexa Diiorio, Kristin O'Malley, Lara McGrath, Margaret Willer, Lauren Pepper, Monica Gostissa, Katalin Kis-Toth, Dmitri Wiederschain, Heather Cohen, Donald R. Shaffer
Publikováno v:
Molecular Cancer Therapeutics. 22:471-484
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdc9ed87146b6d569a16703ed901dc0f
https://doi.org/10.1158/1535-7163.mct-22-0351
https://doi.org/10.1158/1535-7163.mct-22-0351
Autor:
Edward Stack, Jeff Smith, Yasmin Hashambhoy-Ramsay, Vikki Spaulding, Michelle Priess, Kristin O’Malley, Monica Gostissa, Margaret Willer, Ben Umiker, Donald Shaffer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/945c3ea2eb844800ad50a8f0bfc39d5e
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Sensitivity of LILRB2 as a predictive biomarker for pharmacodynamic response as measured by the macrophage polarization score in histoculture explant cultures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7300803b6c2959ff55929ff818f38977
https://doi.org/10.1158/1535-7163.22551994.v1
https://doi.org/10.1158/1535-7163.22551994.v1
Autor:
Donald R. Shaffer, Heather Cohen, Dmitri Wiederschain, Katalin Kis-Toth, Monica Gostissa, Lauren Pepper, Margaret Willer, Lara McGrath, Kristin O'Malley, Alexa Diiorio, Masie Wong, Abha Dhaneshwar, Michelle Priess, Vikki Spaulding, Allison Goodman, Kristin Krukenberg, Sarah Jaffe, Mohammad Murshid Alam, Gayatri Patankar, Christina Meyer, Rachel Davidson, Amy Mueller, Tanzila Rahman, Jeff Smith, Yasmin Hashambhoy-Ramsay, Ben Umiker
Tumor-associated macrophages (TAM) play an important role in maintaining the immunosuppressive state of the tumor microenvironment (TME). High levels of CD163+ TAMs specifically are associated with poor prognosis in many solid tumor types. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e89f1a6392cc21d33474e1853be7817
https://doi.org/10.1158/1535-7163.c.6534805.v1
https://doi.org/10.1158/1535-7163.c.6534805.v1
Autor:
Jeffrey Smith, Amy Mueller, Vikki Spaulding, Michelle Priess, Krithi Bala, Andrew Dunn, Sarah Jaffe, Morgan Thompson, Jean-Christophe Pignon, Alexa Diiorio, Andre Cunha, Heather Condurso, Kristin O’Malley, Olivia Petrillo, Prashanna Balaji Venkatasubramanian, Geneva Young, Christina Meyer, Michael Meehl, Katalin Kis-Toth, Monica Gostissa, Dmitri Wiederschain, Ben Umiker, Yasmin Hashambhoy-Ramsay
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::505698af8389532225c27d5331c45b5e
https://doi.org/10.1136/jitc-2022-sitc2022.0945
https://doi.org/10.1136/jitc-2022-sitc2022.0945
Autor:
Kristin Shanea O'malley, Mark Yore, Reva Shenwai, Ben Umiker, Jeffrey W. Smith, Johan Baeck, Kristen Legendre, Lara McGrath, Allison L Naumovski, Margaret Willer, Tanzila Rahman, Andrew Dunn, Edward C. Stack, Amy Mueller
Publikováno v:
Cancer Research. 81:1727-1727
Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is expressed on myeloid cells and inhibits myeloid cell activation through binding Major Histocompatibility class I (MHC-I) molecules. These include Human Leukocyte Antigen-G (HLA-G), which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d49af4f3a7004b05a4469bea6e71fbe
https://doi.org/10.1158/1538-7445.am2021-1727
https://doi.org/10.1158/1538-7445.am2021-1727
Autor:
Donald R. Shaffer, Vikki Spaulding, Edward C. Stack, Kristin Shanea O'malley, Jeffrey W. Smith, Ben Umiker, Margaret Willer, Michelle Priess, Monica Gostissa, Yasmin Hashambhoy-Ramsay
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Leukocyte immunoglobulin-like receptor B2 (LILRB2; ILT4) is an immunoinhibitory protein expressed on the surface of myeloid cells that has been increasingly recognized as a therapeutic target of interest in immuno-oncology (IO). Upon bindi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc704ce7e919eef0c6929caeaabe8d18
https://doi.org/10.1136/jitc-2020-sitc2020.0217
https://doi.org/10.1136/jitc-2020-sitc2020.0217
Autor:
Donald R. Shaffer, Seema Naheed, Chang-Ai Xu, Michael A. Meehl, Jessica Weaver, Monica Gostissa, Edward C. Stack, Joshua Adam Buggé, Masie Wong, Yan Zhang, Vikki Spaulding, Margaret Willer, Alessandro Mora, Anirudh Singh, Kristan Meetze, Lara McGrath, Boris Klebanov, Christine Fregeau, Fabien Dépis, Dhruvkumar Upadhyay, Michelle Priess, Changyun Hu, Ben Umiker, Kristin Legendre
Publikováno v:
Cancer Research. 80:4532-4532
Introduction: Immune checkpoint blockade (ICB) has revolutionized the treatment of many cancers, still most patients do not respond to PD-1 or CTLA-4 inhibitors. Thus, new Immuno-Oncology (IO) therapies that could potentially benefit non-responding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14b5213193fab5060f3cc3592ee811dd
https://doi.org/10.1158/1538-7445.am2020-4532
https://doi.org/10.1158/1538-7445.am2020-4532
Autor:
Nehal Lakhani, Kyriakos P. Papadopoulos, Weidong Zhang, Elizabeth Trehu, Johan Baeck, Timothy A. Yap, Nancy Mota, Lara McGrath, Haley Laken, Allison L Naumovski, Ben Umiker, Karen Brown, Christina Tasillo, Gosia Riley, Edward C. Stack
Publikováno v:
Journal of Clinical Oncology. 39:TPS2672-TPS2672
TPS2672 Background: Leukocyte Immunoglobulin-like receptor B2 [LILRB2; immunoglobulin-like transcript 4 (ILT4)] is an immunoinhibitory protein expressed on the surface of myeloid cells and is a therapeutic target of interest in immuno-oncology. Publi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da4c67235b1bd81d0c7ae6c64877a691
https://doi.org/10.1200/jco.2021.39.15_suppl.tps2672
https://doi.org/10.1200/jco.2021.39.15_suppl.tps2672
Autor:
Jasbir Seehra, Ben Umiker, Joseph Barberio, Kathryn W. Underwood, Jeffrey A. Ucran, Alan Koncarevic, June Liu, Katia Liharska, Matthew S. Spaits, Jennifer Lachey, Monique V. Davies, Scott Pearsall, Kathleen N. Tomkinson, Ravindra Kumar, Theresa Baker, Abigail Pullen, Travis E. Monnell, Elizabeth Howard, Sako Dianne S, Milton Cornwall-Brady, Asya Grinberg
Publikováno v:
Endocrinology. 151(9)
Androgen deprivation, a consequence of hypogonadism, certain cancer treatments, or normal aging in men, leads to loss of muscle mass, increased adiposity, and osteoporosis. In the present study, using a soluble chimeric form of activin receptor type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f08f742b552fecca4ccc8de8af2a1c1
https://pubmed.ncbi.nlm.nih.gov/20573726
https://pubmed.ncbi.nlm.nih.gov/20573726