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Akademický článek

A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-16 (2024)

Abstract Background Group A streptococci (Strep A) orStreptococcus pyogenes is a major human pathogen causing an estimated 500,000 deaths worldwide each year. Disease can range from mild pharyngitis to more severe infections, such as necrotizing fasc

Externí odkaz: https://doaj.org/article/3b507af6859c43d3b742a62462d6dfde

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Akademický článek

Development and Evaluation of an Audit and Feedback Process for Prevention of Acute Kidney Injury During Coronary Angiography and Intervention

Autor: Bryan Ma, BSc, Peter Faris, PhD, Bryan J. Har, MD, MPH, Ben Tyrrell, MD, Eleanor Benterud, MN, John A. Spertus, MD, Neesh Pannu, MD, SM, Braden J. Manns, MD, MSc, Michelle M. Graham, MD, Matthew T. James, MD, PhD

Publikováno v: CJC Open, Vol 4, Iss 3, Pp 271-281 (2022)

Background: Contrast-associated acute kidney injury (CA-AKI) is a potentially preventable complication of coronary angiography and intervention. Relatively little research has been done to determine how knowledge on CA-AKI prevention can be translate

Externí odkaz: https://doaj.org/article/0c5548c3e58b429cbf206492e92dc389

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Patient Experience After Risk Stratification and Follow-up for Acute Kidney Injury After Cardiac Catheterization: Patient Survey

Autor: Zhi Tan, Eleanor Benterud, Matthew T. James, Denise Kruger, Ben Tyrrell, Pantea Amin Javaheri, Winnie Pearson, Bryan Ma, Bryan Har, Jennifer Natha, Michelle M. Graham

Publikováno v: CJC Open, Vol 3, Iss 3, Pp 337-344 (2021)
CJC Open

Background: Acute kidney injury (AKI) after cardiac catheterization procedures is associated with poor health outcomes. We sought to characterize the experiences of patients after receiving standardized information on their risk of AKI accompanied by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a268ae7578a7b01948f7891336225f7c
http://www.sciencedirect.com/science/article/pii/S2589790X20301918

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Development and Evaluation of an Audit and Feedback Process for Prevention of Acute Kidney Injury During Coronary Angiography and Intervention

Autor: Matthew T. James, Peter Faris, Eleanor Benterud, Bryan Ma, Braden Manns, Michelle M. Graham, Ben Tyrrell, Bryan Har, Neesh Pannu, John A. Spertus

Publikováno v: CJC open. 4(3)

Contrast-associated acute kidney injury (CA-AKI) is a potentially preventable complication of coronary angiography and intervention. Relatively little research has been done to determine how knowledge on CA-AKI prevention can be translated into clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610f7938203fbce91c96fe3a4b11f832
https://pubmed.ncbi.nlm.nih.gov/35386131

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Clinical Decision Support to Reduce Contrast-Induced Kidney Injury During Cardiac Catheterization: Design of a Randomized Stepped-Wedge Trial

Autor: Neesh Pannu, Matthew T. James, Tolulope T. Sajobi, David Allen, Ben Tyrrell, Bryan Ma, Michelle M. Graham, John A. Spertus, Peter Faris, Stephen B. Wilton, Bryan Har, Scott Klarenbach

Publikováno v: The Canadian journal of cardiology. 35(9)

Background Contrast-induced acute kidney injury (CI-AKI) is a common and serious complication of invasive cardiac procedures. Quality improvement programs have been associated with a lower incidence of CI-AKI over time, but there is a lack of high-qu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da50ad0506b0bdee17f8fc2e97fd81e0
https://pubmed.ncbi.nlm.nih.gov/35114163

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Preferential Expression and Function of Voltage-Gated, O 2 -Sensitive K + Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction

Autor: Kyoko Hashimoto, M. Sean McMurtry, Gwyneth Harry, Stephen L. Archer, Xichen Wu, Ben Tyrrell, Sébastien Bonnet, Evangelos D. Michelakis, Bernard Thébaud, Ali Nsair

Publikováno v: Circulation Research. 95:308-318

Hypoxic pulmonary vasoconstriction (HPV) is initiated by inhibition of O 2 -sensitive, voltage-gated (Kv) channels in pulmonary arterial smooth muscle cells (PASMCs). Kv inhibition depolarizes membrane potential (E M ), thereby activating Ca 2+ influ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d2bcbe8cc2361c577948f465338ca46
https://doi.org/10.1161/01.res.0000137173.42723.fb

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REAL WORLD RELATIONSHIPS BETWEEN BASELINE Q WAVES, TIME FROM SYMPTOM ONSET AND CLINICAL OUTCOMES IN ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS: INSIGHT FROM THE VITAL HEART RESPONSE REGISTRY

Autor: Robert C. Welsh, Kevin R. Bainey, Ben Tyrrell, Paul W. Armstrong, Yinggan Zheng, Neil Brass

Publikováno v: Journal of the American College of Cardiology. 69:170

Background: Baseline Q waves on the initial 12-lead ECG in clinical trials has been shown to be a simple predictor of clinical outcomes in STEMI patients. Whether this relationship applies in real world STEMI care is unknown. Using a large comprehens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89741ec8fc5e715f6a4920c83664618b
https://doi.org/10.1016/s0735-1097(17)33559-3

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Impact of reperfusion strategy on aborted myocardial infarction: insights from a large Canadian ST-Elevation Myocardial Infarction Clinical Registry

Autor: Craig Ferguson, Robert C. Welsh, Kevin R. Bainey, Ben Tyrrell, Quazi Ibrahim

Publikováno v: The Canadian journal of cardiology. 30(12)

Reperfusion in ST-elevation myocardial infarction (STEMI) improves survival. Moreover, early reperfusion can abort the infarct and avoid significant myocardial necrosis. Yet, limited real world data exist and comparison between reperfusion strategies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3249178da80925e3ae6e76fe0a7d3d2
https://pubmed.ncbi.nlm.nih.gov/25475462

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