Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ben Tsuda"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011618 (2023)
Animal models are used to understand principles of human biology. Within cognitive neuroscience, non-human primates are considered the premier model for studying decision-making behaviors in which direct manipulation experiments are still possible. S
Externí odkaz:
https://doaj.org/article/715556fec5b146619b7ec2eb7c346860
Autor:
Cleber A Trujillo, Jason W Adams, Priscilla D Negraes, Cassiano Carromeu, Leon Tejwani, Allan Acab, Ben Tsuda, Charles A Thomas, Neha Sodhi, Katherine M Fichter, Sarah Romero, Fabian Zanella, Terrence J Sejnowski, Henning Ulrich, Alysson R Muotri
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Duplication or deficiency of the X‐linked MECP2 gene reliably produces profound neurodevelopmental impairment. MECP2 mutations are almost universally responsible for Rett syndrome (RTT), and particular mutations and cellular mosaicism of M
Externí odkaz:
https://doaj.org/article/62a5f92686b74314967f1f52b82ce189
Autor:
H Efsun Arda, Stefan Taubert, Lesley T MacNeil, Colin C Conine, Ben Tsuda, Marc Van Gilst, Reynaldo Sequerra, Lynn Doucette‐Stamm, Keith R Yamamoto, Albertha J M Walhout
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principle
Externí odkaz:
https://doaj.org/article/3a65b7317a6a45a985811f7268e68db3
Mood, arousal, and other internal states can drastically alter behavior, even in identical external circumstances — a cold glass of water when you are thirsty is much more desirable than when you are sated. Neuromodulators are critical controllers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9782d0c6f1f50f06b949532e0bf3360f
https://doi.org/10.1101/2021.05.31.446462
https://doi.org/10.1101/2021.05.31.446462
Autor:
Keerthana Gnanapradeepan, Xiaolan Zhang, Robert H. Rice, Jose C. Florez, Marjoleine F. Broekema, Maura Agostini, Stephen O'Rahilly, Amit R. Majithia, Ben Tsuda, Inês Barroso, Kashyap A. Patel, Krishna Chatterjee, Tarjei S. Mikkelsen, Sekar Kathiresan, Eric Kalkhoven, Gina M. Peloso, Evan D. Rosen, Ted Sharpe, David Altshuler, David B. Savage, Marc Duby, Nick Patterson, Sian Ellard
Publikováno v:
Nature genetics
Amit Majithia and colleagues employ a pooled assay in human macrophages to assess the functional effects of all possible missense variants in PPARG. Their study shows the value of saturation mutagenesis and prospective experimental characterization t
Autor:
H. Efsun Arda, Lynn Doucette-Stamm, Ben Tsuda, Keith R. Yamamoto, Lesley T. MacNeil, Albertha J.M. Walhout, Colin C. Conine, Marc R. Van Gilst, Stefan Taubert, Reynaldo Sequerra
Publikováno v:
Molecular Systems Biology
We present the first gene regulatory network (GRN) that pertains to post-developmental gene expression. Specifically, we mapped a transcription regulatory network of Caenorhabditis elegans metabolic gene promoters using gene-centered yeast one-hybrid
Autor:
Volker Busskamp, Witold Filipowicz, Dasha Nelidova, Josephine Jüttner, Brigitte Gross Scherf, Naoyuki Tanimoto, Ben Tsuda, Michael B. Stadler, Karl Farrow, Tamas Szikra, Mathias W. Seeliger, Claudia Patricia Patino Alvarez, Markus Stoffel, Vithiyanjali Sothilingam, Jacek Krol, Christel Genoud, Janine M Daum, Botond Roska
Publikováno v:
Neuron
SummaryThe outer segments of cones serve as light detectors for daylight color vision, and their dysfunction leads to human blindness conditions. We show that the cone-specific disruption of DGCR8 in adult mice led to the loss of miRNAs and the loss