Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Ben Tseng"'
Publikováno v:
Case Reports in Neurological Medicine, Vol 2014 (2014)
Acute onset of psychosis in an older or elderly individual without history of previous psychiatric disorders should prompt a thorough workup for neurologic causes of psychiatric symptoms. This report compares and contrasts clinical features of new on
Externí odkaz:
https://doaj.org/article/275e6f050b214ee199a8c6aa023c0d5a
Autor:
Ritobrato Datta, Jongho Lee, Jeffrey Duda, Brian B. Avants, Charles H. Vite, Ben Tseng, James C. Gee, Gustavo D. Aguirre, Geoffrey K. Aguirre
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/916074a044e44ea8b4bfa83e747da80c
Autor:
Ritobrato Datta, Jongho Lee, Jeffrey Duda, Brian B Avants, Charles H Vite, Ben Tseng, James C Gee, Gustavo D Aguirre, Geoffrey K Aguirre
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52140 (2012)
There is a long history and a growing interest in the canine as a subject of study in neuroscience research and in translational neurology. In the last few years, anatomical and functional magnetic resonance imaging (MRI) studies of awake and anesthe
Externí odkaz:
https://doaj.org/article/5c35ef55cf384321b72870411e38fbf3
Autor:
Shailaja Kasibhatla, Sui Xiong Cai, Ben Tseng, John Drewe, Kurt Gehlsen, Han-Zhong Zhang, Jared Kuemmerle, Regina Brand, Ling Qiu, Shannon P. Archer, Sergei Maliartchouk, Jean Yu Wang, Nicole M. English, Katayoun A. Jessen
A novel series of 3,5-diaryl-oxadiazoles was identified as apoptosis-inducing agents through our cell and chemical genetics–based screening assay for compounds that induce apoptosis using a chemical genetics approach. Several analogues from this se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb3bfcd1dfef46e1a3e3bea0faec7fa
https://doi.org/10.1158/1535-7163.c.6531578
https://doi.org/10.1158/1535-7163.c.6531578
Autor:
Shailaja Kasibhatla, Sui Xiong Cai, Ben Tseng, John Drewe, Kurt Gehlsen, Han-Zhong Zhang, Jared Kuemmerle, Regina Brand, Ling Qiu, Shannon P. Archer, Sergei Maliartchouk, Jean Yu Wang, Nicole M. English, Katayoun A. Jessen
Expression profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9f90662c32766c201560f506e609a5
https://doi.org/10.1158/1535-7163.22484774.v1
https://doi.org/10.1158/1535-7163.22484774.v1
Autor:
Candace Crogan-Grundy, Nilantha Sudath Sirisoma, Shailaja Kasibhatla, Sui Xiong Cai, William Kemnitzer, Songchun Jiang, John Drewe, Ben Tseng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1288-1292
As a continuation of our studies of apoptosis inducing 9-oxo-9H-fluorene-1-carboxamides as potential anticancer agents, we explored modification of the 9-oxo-9H-fluorene ring. SAR studies showed that most changes to the 9-oxo-9H-fluorene ring were no
Autor:
John Drewe, Ben Tseng, William Kemnitzer, Shailaja Kasibhatla, Sui Xiong Cai, Han-Zhong Zhang, Jared Kuemmerle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4410-4415
As a continuation of our efforts to discover and develop the 3-aryl-5-aryl-1,2,4-oxadiazole series of apoptosis inducers as potential anticancer agents, we explored substitutions at the 2- and 3-positions of the 3-aryl group to improve the aqueous so
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3536-3540
We report the discovery of N-((benzo[d][1,3]dioxol-5-yl)methyl)-6-phenylthieno[3,2-d]pyrimidin-4-amine (2a) as an apoptosis inducer using our proprietary cell- and caspase-based ASAP HTS assay, and SAR study of HTS hit 2a which led to the discovery o
Autor:
William, Kemnitzer, Jared, Kuemmerle, Songchun, Jiang, Nilantha, Sirisoma, Shailaja, Kasibhatla, Candace, Crogan-Grundy, Ben, Tseng, John, Drewe, Sui Xiong, Cai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3481-3484
As a continuation of our efforts to discover and develop the apoptosis inducing 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as potential anticancer agents, we explored substitutions at the 4-, 5-, 6-, 7- and 8-positions of pyrrolo[1,2-a]quinoline. SAR
Autor:
William, Kemnitzer, Nilantha, Sirisoma, Bao, Nguyen, Songchun, Jiang, Shailaja, Kasibhatla, Candace, Crogan-Grundy, Ben, Tseng, John, Drewe, Sui Xiong, Cai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3045-3049
N-(2-Methylphenyl)-9-oxo-9H-fluorene-1-carboxamide (2a) was identified as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 2a was found to be active with sub-micromolar potencies for both caspase