Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ben T. Jordan"'
Autor:
Vladimir B. C. de Souza, Ben T. Jordan, Elizabeth Tseng, Elizabeth A. Nelson, Karen K. Hirschi, Gloria Sheynkman, Mark D. Robinson
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Long-read RNA sequencing (lrRNA-seq) produces detailed information about full-length transcripts, including novel and sample-specific isoforms. Furthermore, there is an opportunity to call variants directly from lrRNA-seq data. However, most
Externí odkaz:
https://doaj.org/article/29a834968197445ca6a1f65ac1700bd1
Autor:
Madison M. Mehlferber, Erin D. Jeffery, Jamie Saquing, Ben T. Jordan, Leon Sheynkman, Mayank Murali, Gael Genet, Bipul R. Acharya, Karen K. Hirschi, Gloria M. Sheynkman
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 1228-1243 (2022)
Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isoforms. To char
Externí odkaz:
https://doaj.org/article/25c3d2515f1f46dfae2eadfff827bcc1
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Kinases are important drug targets, but predicting their activities from phosphoproteomics data remains challenging. While many existing prediction tools rely on phosphosite-specific quantitative data, Crowl et al. develop a kinase activity predictio
Externí odkaz:
https://doaj.org/article/17765b6e09df4c2d805f950c93df9c4b
Autor:
Rachel M. Miller, Ben T. Jordan, Madison M. Mehlferber, Erin D. Jeffery, Christina Chatzipantsiou, Simi Kaur, Robert J. Millikin, Yunxiang Dai, Simone Tiberi, Peter J. Castaldi, Michael R. Shortreed, Chance John Luckey, Ana Conesa, Lloyd M. Smith, Anne Deslattes Mays, Gloria M. Sheynkman
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-28 (2022)
Abstract Background The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteo
Externí odkaz:
https://doaj.org/article/776c8d64ef7d4a0fac40342a93d172bb
Autor:
Szi Kay Leung, Aaron R. Jeffries, Isabel Castanho, Ben T. Jordan, Karen Moore, Jonathan P. Davies, Emma L. Dempster, Nicholas J. Bray, Paul O’Neill, Elizabeth Tseng, Zeshan Ahmed, David A. Collier, Erin D. Jeffery, Shyam Prabhakar, Leonard Schalkwyk, Connor Jops, Michael J. Gandal, Gloria M. Sheynkman, Eilis Hannon, Jonathan Mill
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110022- (2021)
Summary: Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA molecules from a single pre-mRNA with a prominent role in the development and function of the central nervous system. We used long-read isoform seque
Externí odkaz:
https://doaj.org/article/1417caefb134428cac84fed4a4f86a78
Autor:
Madison M. Mehlferber, Ben T. Jordan, Erin D. Jeffery, Leon Sheynkman, Jamie Saquing, Bipul R. Acharya, Karen K. Hirschi, Gloria M. Sheynkman
Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by protein isoforms. To characterize the isoform landscape within ECs, we ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e72d29046c78f3634f1f0e9097c820b7
https://doi.org/10.1101/2022.05.17.490813
https://doi.org/10.1101/2022.05.17.490813
Autor:
Vladimir B. C. de Souza, Ben T. Jordan, Elizabeth Tseng, Elizabeth A. Nelson, Karen K. Hirschi, Gloria Sheynkman, Mark D. Robinson
Long-read RNA sequencing (lrRNA-seq) produces detailed information about full-length transcripts, including novel and sample-specific isoforms. Furthermore, there is an opportunity to call variants directly from lrRNA-seq data. However, most state-of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483b28b608c81a48edb0a395ddd3a8fc
https://doi.org/10.1101/2022.02.08.479579
https://doi.org/10.1101/2022.02.08.479579
Publikováno v:
Nature communications. 13(1)
Kinase inhibitors as targeted therapies have played an important role in improving cancer outcomes. However, there are still considerable challenges, such as resistance, non-response, patient stratification, polypharmacology, and identifying combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a31954e6538267dca9bd7631a96c00a
https://pubmed.ncbi.nlm.nih.gov/35879309
https://pubmed.ncbi.nlm.nih.gov/35879309
Kinase inhibitors are one of the largest classes of FDA-approved drugs and are major targets in oncology. Although kinase inhibitors have played an important role in improving cancer outcomes, major challenges still exist, including the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9c4400a47b601eb9a19d212945f5e8
https://doi.org/10.1101/2021.07.06.451378
https://doi.org/10.1101/2021.07.06.451378
Autor:
Paul O'Neill, Michael J. Gandal, Aaron R. Jeffries, Szi Kay Leung, Jonathan Mill, Connor Jops, Zeshan Ahmed, Emma Dempster, Nicholas John Bray, Shyam Prabhakar, Karen Moore, Jonathan P. Davies, Elizabeth Tseng, David A. Collier, Gloria M. Sheynkman, Ben T. Jordan, Erin D. Jeffery, Eilis Hannon, Isabel Castanho, Leonard C. Schalkwyk
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110022-(2021)
Cell Reports
Cell Reports
Summary Alternative splicing is a post-transcriptional regulatory mechanism producing distinct mRNA molecules from a single pre-mRNA with a prominent role in the development and function of the central nervous system. We used long-read isoform sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af2641cf58c273996e17d15728b8f61
https://doi.org/10.1016/j.celrep.2021.110022
https://doi.org/10.1016/j.celrep.2021.110022