Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ben Saer"'
Autor:
Helen E. Chmura, Cassandra Duncan, Ben Saer, Jeanette T. Moore, Brian M. Barnes, C. Loren Buck, Helen C. Christian, Andrew S. I. Loudon, Cory T. Williams
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Arctic ground squirrels hibernating in darkness activate the pars tuberalis - hypothalamus thyroid hormone signaling pathway, remodel hypothalamic tanycytes, and activate the reproductive axis.
Externí odkaz:
https://doaj.org/article/6832b2903caa4c0e9e095e8e29ccf0e8
Autor:
Helen E Chmura, Cassandra Duncan, Ben Saer, Jeanette T Moore, Brian M Barnes, C Loren Buck, Andrew S I Loudon, Cory T Williams
Publikováno v:
Integr Comp Biol
Many animals adjust the timing of seasonal events, such as reproduction, molt, migration, and hibernation, in response to interannual variation and directional climate-driven changes in temperature. However, the mechanisms by which temperature influe
Autor:
John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell
Publikováno v:
Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p
Autor:
Helen E. Chmura, Cassandra Duncan, Ben Saer, Jeanette T. Moore, Brian M. Barnes, C. Loren Buck, Helen C. Christian, Andrew S. I. Loudon, Cory T. Williams
Publikováno v:
Communications biology. 5(1)
Hibernation involves prolonged intervals of profound metabolic suppression periodically interrupted by brief arousals to euthermy, the function of which is unknown. Annual cycles in mammals are timed by a photoperiodically-regulated thyroid-hormone-d
Autor:
Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley
Publikováno v:
Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z
The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe68ec4d59282f4ea3b26b1fb3be070
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d
Autor:
Zhenguang, Zhang, Louise, Hunter, Gang, Wu, Robert, Maidstone, Yasutaka, Mizoro, Ryan, Vonslow, Mark, Fife, Thomas, Hopwood, Nicola, Begley, Ben, Saer, Ping, Wang, Peter, Cunningham, Matthew, Baxter, Hannah, Durrington, John F, Blaikley, Tracy, Hussell, Magnus, Rattray, John B, Hogenesch, Julie, Gibbs, David W, Ray, Andrew S I, Loudon
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5)
Pulmonary airway epithelial cells (AECs) form a critical interface between host and environment. We investigated the role of the circadian clock using mice bearing targeted deletion of the circadian gene brain and muscle ARNT-like 1 (Bmal1) in AECs.
Autor:
Patricia L. Podolin, Justyna Wojno-Picon, Baoqiang Guo, Andrew S. I. Loudon, Ryan Vonslow, Ryan P. Trump, Daniel Grant, Andrew S. MacDonald, Yolanda Sanchez, Anthony William James Cooper, Marie Pariollaud, D. Heulyn Jones, Brian Bolognese, Nicholas C. O. Tomkinson, Thomas Hopwood, Stefano Bresciani, David W. Ray, William J. Zuercher, Nicola Begley, Timothy M. Willson, Sheila Brown, Toryn Poolman, James P. Tellam, Dion A. Daniels, Ben Saer, Julie E. Gibbs
Publikováno v:
Pariollaud, M, Gibbs, J, Hopwood, T, Brown, S, Begley, N, Vonslow, R, Poolman, T, Guo, B, Saer, B, Jones, D H, Tellam, J P, Bresciani, S, Tomkinson, N C, Wojno-Picon, J, Cooper, A W, Daniels, D A, Trump, R P, Grant, D, Zuercher, W, Willson, T M, MacDonald, A S, Bolognese, B, Podolin, P L, Sanchez, Y, Loudon, A S & Ray, D W 2018, ' Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation ', The Journal of clinical investigation, vol. 128, no. 6, pp. 2281-2296 . https://doi.org/10.1172/JCI93910
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Recent studies reveal that airway epithelial cells are critical pulmonary circadian pacemaker cells, mediating rhythmic inflammatory responses. Using mouse models, we now identify the rhythmic circadian repressor REV-ERBα as essential to the mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b850d90e252cb0cef62edd168f157db
https://strathprints.strath.ac.uk/64982/1/Pariollaud_etal_JCI2018_Circadian_clock_component_REV_ERBa_controls_homeostatic_regulation.pdf
https://strathprints.strath.ac.uk/64982/1/Pariollaud_etal_JCI2018_Circadian_clock_component_REV_ERBa_controls_homeostatic_regulation.pdf
Autor:
David W. Ray, Laura Matthews, Thomas J. Bell, Francesco J. DeMayo, Stuart N. Farrow, Nan Yang, Ben Saer, Julie E. Gibbs, Marie Pariollaud, G. Scott Worthen, Junjie Mei, Toryn Poolman, Nicola Begley, Tracy Hussell, Andrew S. I. Loudon, Louise Ince
Publikováno v:
Nature Medicine. 20:919-926
The circadian system is an important regulator of immune function. Human inflammatory lung diseases frequently show time-of-day variation in symptom severity and lung function, but the mechanisms and cell types underlying these effects remain unclear
Autor:
Andrew S. I. Loudon, Simon T. Hui, Stephan Steinlechner, David A. Bechtold, Laura E. Hand, Ben Saer, Hyder A. Jinnah
Publikováno v:
Endocrinology
Torpor is a physiological state characterized by controlled lowering of metabolic rate and core body temperature, allowing substantial energy savings during periods of reduced food availability or harsh environmental conditions. The hypothalamus coor
Autor:
Johanna E. Chesham, Raymond P. Boot-Handford, Nicola J. Smyllie, Michael R. H. White, David G. Spiller, Michael H. Hastings, Toke P. Krogager, Andrew S. I. Loudon, Elizabeth S. Maywood, Qing-Jun Meng, James Boyd, Ben Saer, Violetta Pilorz
Publikováno v:
Smyllie, N J, Pilorz, V, Boyd, J, Meng, Q-J, Saer, B, Chesham, J E, Maywood, E S, Krogager, T P, Spiller, D, Boot-Handford, R, White, M, Hastings, M H & Loudon, A 2016, ' Visualizing and Quantifying Intracellular Behavior and Abundance of the Core Circadian Clock Protein PERIOD2 ', Current Biology, vol. 26, no. 14, pp. 1880-1886 . https://doi.org/10.1016/j.cub.2016.05.018
Current Biology
CURRENT BIOLOGY
Current Biology
CURRENT BIOLOGY
Summary Transcriptional-translational feedback loops (TTFLs) are a conserved molecular motif of circadian clocks. The principal clock in mammals is the suprachiasmatic nucleus (SCN) of the hypothalamus. In SCN neurons, auto-regulatory feedback on cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e457860f22b427eb84962d76d42b25
https://doi.org/10.1016/j.cub.2016.05.018
https://doi.org/10.1016/j.cub.2016.05.018