Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ben Rollo"'
Autor:
Simon Maksour, Neville Ng, Amy J. Hulme, Sara Miellet, Martin Engel, Sonia Sanz Muñoz, Rachelle Balez, Ben Rollo, Rocio K. Finol-Urdaneta, Lezanne Ooi, Mirella Dottori
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e32680- (2024)
Repressor element-1 silencing transcription factor (REST) is a transcriptional repressor involved in neurodevelopment and neuroprotection. REST forms a complex with the REST corepressors, CoREST1, CoREST2, or CoREST3 (encoded by RCOR1, RCOR2, and RCO
Externí odkaz:
https://doaj.org/article/2ccd3caa1e844c4b86d0e4c2a10532f7
Autor:
Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O’Brien, David K. Wright
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-11 (2022)
Abstract Background Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (ALS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic function early in t
Externí odkaz:
https://doaj.org/article/72df01f2f3c644b5aedce4b1ed879bf4
Autor:
Lisseth Estefania Burbano, Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Kay Richards, Alicia Sedo, Armand Soriano, Ben Rollo, Linghan Jia, Elena V. Gazina, Sandra Piltz, Fatwa Adikusuma, Paul Q. Thomas, Helen Kopsidas, Frank Rigo, Christopher A. Reid, Snezana Maljevic, Steven Petrou
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Developmental and epileptic encephalopathies (DEEs) are characterized by pharmaco-resistant seizures with concomitant intellectual disability. Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the most severe of these syndromes. De
Externí odkaz:
https://doaj.org/article/94df65e871214a28a1b39d45e79f1372
Autor:
Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O'Brien, David K. Wright
Publikováno v:
NeuroImage: Clinical, Vol 34, Iss , Pp 103016- (2022)
Amyotrophic lateral sclerosis (ALS) is characterized by transactive response DNA-binding protein 43 (TDP-43) pathology, progressive loss of motor neurons and muscle dysfunction. Symptom onset can be insidious and diagnosis challenging. Conventional n
Externí odkaz:
https://doaj.org/article/057c1c687ea841a5b53dc2071a84a1bb
Autor:
Robert J. Hatch, Géza Berecki, Nikola Jancovski, Melody Li, Ben Rollo, Paymaan Jafar-Nejad, Frank Rigo, Kai Kaila, Christopher A. Reid, Steven Petrou
Publikováno v:
The Journal of Neuroscience. 43:1658-1667
Brain pH is a critical factor for determining neuronal activity, with alkalosis increasing and acidosis reducing excitability. Acid shifts in brain pH through the breathing of carbogen (5% CO2/95% O2) reduces seizure susceptibility in animal models a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720c03448515d174cd1c2af12ff86e89
https://doi.org/10.1523/jneurosci.1387-22.2022
https://doi.org/10.1523/jneurosci.1387-22.2022
Autor:
Nicole J. Van Bergen, Sean Massey, Anita Quigley, Ben Rollo, Alexander R. Harris, Robert M.I. Kapsa, John Christodoulou
Publikováno v:
Biochemical Society Transactions. 50:1207-1224
CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene. Individuals with CDD suffer infantile onset, drug-resistant seizures, severe neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b12ede1d806492cce1e10dcfe4a1c6
https://doi.org/10.1042/bst20220791
https://doi.org/10.1042/bst20220791
Autor:
Jo‐Anne Baltos, Pablo M. Casillas‐Espinosa, Ben Rollo, Karen J. Gregory, Paul J. White, Arthur Christopoulos, Patrick Kwan, Terence J. O'Brien, Lauren T. May
Publikováno v:
British Journal of Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70a8425ab851eb752c9615e13d4c5b9e
https://doi.org/10.1111/bph.16094
https://doi.org/10.1111/bph.16094
Autor:
Miaomiao Mao, Cristiana Mattei, Ben Rollo, Sean Byars, Claire Cuddy, Geza Berecki, Jacqueline Heighway, Svenja Pachernegg, Trevelyan Menheniott, Danielle Apted, Linghan Jia, Kelley Dalby, Alex Nemiroff, Saul Mullen, Christopher A. Reid, Snezana Maljevic, Steven Petrou
SCN2Aencodes NaV1.2, an excitatory neuron voltage-gated sodium channel and major monogenic cause of neurodevelopmental disorders, including developmental and epileptic encephalopathies (DEE) and autism. Clinical presentation and pharmocosensitivity v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c109162970dd262c7075eb176feae510
https://doi.org/10.1101/2023.02.14.528217
https://doi.org/10.1101/2023.02.14.528217
Autor:
Brett J. Kagan, Adeel Razi, Anjali Bhat, Andy C. Kitchen, Nhi T. Tran, Forough Habibollahi, Moein Khajehnejad, Bradyn J. Parker, Ben Rollo, Karl J. Friston
Publikováno v:
Neuron. 111:606-607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6aa5b54bedbcf2ea57f664c63f8f741
https://doi.org/10.1016/j.neuron.2023.02.008
https://doi.org/10.1016/j.neuron.2023.02.008
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2495
CRISPR/Cas9 system is a powerful genome-editing technology for studying genetics and cell biology. Safe harbor sites are ideal genomic locations for transgene integration with minimal interference in cellular functions. Gene targeting of the AAVS1 lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::022e437507ff9a502962a21c0b32eb08
https://pubmed.ncbi.nlm.nih.gov/35696030
https://pubmed.ncbi.nlm.nih.gov/35696030