Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Ben N G, Giepmans"'
Autor:
Mette C. Dekkers, Joost M. Lambooij, Xudong Pu, Raphael R. Fagundes, Agustin Enciso-Martinez, Kim Kats, Ben N. G. Giepmans, Bruno Guigas, Arnaud Zaldumbide
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveBeta cell destruction in type 1 diabetes (T1D) results from the combined effect of inflammation and recurrent autoimmunity. In recent years, the role played by beta cells in the development of T1D has evolved from passive victims of the immu
Externí odkaz:
https://doaj.org/article/2b3c885eac0a4db1b569f2a73fe0eacb
Autor:
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Belend Mahmoud, Albert Gerding, Justina C. Wolters, Anouk H. G. Wolters, Ben N. G. Giepmans, Herman H. W. Silljé, Rudolf A. de Boer, Barbara M. Bakker, B. Daan Westenbrink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes mitochondrial respiration and attenuates mitochondrial oxidative stress in cultured cardiomyocytes. We sought to determine whether AKIP1 influences mitochondrial fu
Externí odkaz:
https://doaj.org/article/0f6febf0dad84f44a4fe25e6b176abbe
Autor:
Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen, Wia Baron
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which increases axo
Externí odkaz:
https://doaj.org/article/95bce4d9d47941768755f87d87b64b26
Autor:
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Harmen G. Booij, Silke U. Oberdorf-Maass, Martin M. Dokter, Anouk H. G. Wolters, Ben N. G. Giepmans, Wiek H. van Gilst, Joan H. Brown, Rudolf A. de Boer, Herman H. W. Silljé, B. Daan Westenbrink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes physiological hypertrophy in vitro. The purpose of this study is to determine if AKIP1 promotes physiological cardiomyocyte hypertrophy in vivo. Therefore, adult ma
Externí odkaz:
https://doaj.org/article/ed562cee66ed427ca8cecb89312bca87
Autor:
Pascal de Boer, Nicole M. Pirozzi, Anouk H. G. Wolters, Jeroen Kuipers, Irina Kusmartseva, Mark A. Atkinson, Martha Campbell-Thompson, Ben N. G. Giepmans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Type 1 diabetes is associated with autoimmune destruction of pancreatic beta-cells. Here the authors compose a large-scale electron microscopy image data base of pancreatic organ donor tissue to enable data mining and further understanding of the dis
Externí odkaz:
https://doaj.org/article/b384446e156a477db4af65825afe3aac
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Volume electron microscopy (EM) of biological systems has grown exponentially in recent years due to innovative large-scale imaging approaches. As a standalone imaging method, however, large-scale EM typically has two major limitations: slow rates of
Externí odkaz:
https://doaj.org/article/febd4f135f224aa09537176997074b33
Autor:
Theodorus W. J. Gadella, Laura van Weeren, Jente Stouthamer, Mark A. Hink, Anouk H. G. Wolters, Ben N. G. Giepmans, Sylvain Aumonier, Jérôme Dupuy, Antoine Royant
Publikováno v:
Nature Methods, 20(4), 541-545. Nature Publishing Group
Nature Methods
Nature Methods, 2023, 20 (4), pp.541-545. ⟨10.1038/s41592-023-01809-y⟩
Nature Methods
Nature Methods, 2023, 20 (4), pp.541-545. ⟨10.1038/s41592-023-01809-y⟩
We report the evolution of mScarlet3, a cysteine-free monomeric red fluorescent protein with fast and complete maturation, as well as record brightness, quantum yield (75%) and fluorescence lifetime (4.0 ns). The mScarlet3 crystal structure reveals a
Autor:
Marit A. de Beer, Ben N. G. Giepmans
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Understanding how building blocks of life contribute to physiology is greatly aided by protein identification and cellular localization. The two main labeling approaches developed over the past decades are labeling with antibodies such as immunoglobu
Externí odkaz:
https://doaj.org/article/079c23b049de47da9145328d9ad54321
Autor:
E. F. Elsiena Kuiper, Paola Gallardo, Tessa Bergsma, Muriel Mari, Maiara Kolbe Musskopf, Jeroen Kuipers, Ben N. G. Giepmans, Anton Steen, Harm H. Kampinga, Liesbeth M. Veenhoff, Steven Bergink
Publikováno v:
Kuiper, E F E, Gallardo, P, Bergsma, T, Mari, M, Kolbe Musskopf, M, Kuipers, J, Giepmans, B N G, Steen, A, Kampinga, H H, Veenhoff, L M & Bergink, S 2022, ' The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis ', Nature Cell Biology, vol. 24, no. 11, pp. 1584-1594 . https://doi.org/10.1038/s41556-022-01010-x
Nature Cell Biology, 24, 1584-1594. Nature Publishing Group
Nature Cell Biology, 24, 1584-1594. Nature Publishing Group
Biogenesis of nuclear pore complexes (NPCs) includes the formation of the permeability barrier composed of phenylalanine-glycine-rich nucleoporins (FG-Nups) that regulate the selective passage of biomolecules across the nuclear envelope. The FG-Nups
Autor:
René van Tienhoven, Maria J. L. Kracht, Arno R. van der Slik, Sofia Thomaidou, Anouk H. G. Wolters, Ben N. G. Giepmans, Juan Pablo Romero Riojas, Michael S. Nelson, Françoise Carlotti, Eelco J. P. de Koning, Rob C. Hoeben, Arnaud Zaldumbide, Bart O. Roep
Publikováno v:
Diabetologia, 66(5), 884-896. SPRINGER
Aims/hypothesis Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative splicing of human INS mRNA in pancreatic islets. Methods Alternative splicing of insulin pre-mRNA was determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078ebd9b4dbdb4aa6a72a2035c08148
http://hdl.handle.net/1887/3619412
http://hdl.handle.net/1887/3619412