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Akademický článek

Widespread chromatin context-dependencies of DNA double-strand break repair proteins

Autor: Xabier Vergara, Anna G. Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Christ Leemans, Anoek Friskes, Roderick L. Beijersbergen, Mathijs A. Sanders, René H. Medema, Bas van Steensel

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The balance of these pathways is dependent on the local chromatin context, but the underly

Externí odkaz: https://doaj.org/article/6009cbab086a43759a3f31b9c33c7f5d

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Akademický článek

Self-efficacy and alcohol consumption: Are efficacy measures confounded with motivation?

Autor: Tom St Quinton, Ben Morris, Alexander Lithopoulos, Paul Norman, Mark Conner, Ryan E. Rhodes

Publikováno v: Cogent Psychology, Vol 10, Iss 1 (2023)

AbstractRecent research has suggested self-efficacy measures (i.e., I can) are confounded with motivation (i.e., I will). The study tested whether two measurement conditions can disentangle motivation from self-efficacy in relation to alcohol consump

Externí odkaz: https://doaj.org/article/7f3b41a7923945f7984ae6bfcc84510f

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Akademický článek

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

Publikováno v: Cell Reports, Vol 42, Iss 5, Pp 112538- (2023)

Summary: BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPis), but they eventually acquire

Externí odkaz: https://doaj.org/article/fd908dcc7cb748d2901dfd4eb935d917

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Akademický článek

Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through

Externí odkaz: https://doaj.org/article/e4c712e9c2534821b3dbea828efb9470

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Akademický článek

Promoting physical activity through text messages: the impact of attitude and goal priority messages

Autor: Tom St Quinton, Ben Morris, Martin J. Barwood, Mark Conner

Publikováno v: Health Psychology and Behavioral Medicine, Vol 9, Iss 1, Pp 165-181 (2021)

Introduction Many young adults demonstrate insufficient rates of physical activity (PA) to yield health benefits. The study tested the effectiveness of a text messaging intervention targeting key psychological determinants and PA. Methods Participant

Externí odkaz: https://doaj.org/article/3579540bae514ad4bdacd15321eeca78

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Akademický článek

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

Autor: Liqin Wang, Rodrigo Leite de Oliveira, Cun Wang, João M. Fernandes Neto, Sara Mainardi, Bastiaan Evers, Cor Lieftink, Ben Morris, Fleur Jochems, Lisa Willemsen, Roderick L. Beijersbergen, René Bernards

Publikováno v: Cell Reports, Vol 21, Iss 3, Pp 773-783 (2017)

Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells can also undergo senescence, but the stresses that provoke cancer cells to undergo senescence are unclear. Here, we use both functional genetic and compound

Externí odkaz: https://doaj.org/article/6000ab834242421891249fb41a57f78a

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