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The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice

Autor: Lisa A Adams, Carol S Himes, Ben M Amore, Kalpana M. Merchant, Shinji Yamazaki, Giovanni Pallante, Thomas A. Lanz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 305(3)

Acute, s.c. administration of a gamma-secretase inhibitor, N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT), to young PDAPP mice dose dependently decreases cortical amyloid-beta (A beta). The present studies replicated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bafcf64667ce6db3399f0a95cc38ce
https://pubmed.ncbi.nlm.nih.gov/12626636

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