Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ben M Abell"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46221 (2012)
G-protein-coupled receptors (GPCRs) are prime drug targets and targeted by approximately 60% of current therapeutic drugs such as β-blockers, antipsychotics and analgesics. However, no biophysical methods are available to quantify their interactions
Externí odkaz:
https://doaj.org/article/a1863166997b4653b776ec3a04f4f05f
Autor:
Verena Kriechbaumer, Alexei Nabok, Mohd K Mustafa, Rukaiah Al-Ammar, Anna Tsargorodskaya, David P Smith, Ben M Abell
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34455 (2012)
Membrane bound receptors play vital roles in cell signaling, and are the target for many drugs, yet their interactions with ligands are difficult to study by conventional techniques due to the technical difficulty of monitoring these interactions in
Externí odkaz:
https://doaj.org/article/136e8c3b151042559651f420fefe2fb9
Publikováno v:
Journal of Biological Chemistry. 277:8602-8610
Oleosin proteins from Arabidopsis assume a unique endoplasmic reticulum (ER) topology with a membrane-integrated hydrophobic (H) domain of 72 residues, flanked by two cytosolic hydrophilic domains. We have investigated the targeting and topological d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514bdd253c03c80b7d8bd7e20ced85ea
https://doi.org/10.1074/jbc.m103712200
https://doi.org/10.1074/jbc.m103712200
Autor:
Ben M. Abell, Verena Kriechbaumer
Publikováno v:
Frontiers in Plant Science
Frontiers in Plant Science, Vol 3 (2012)
Frontiers in Plant Science, Vol 3 (2012)
The general mechanisms of intracellular protein targeting are well established, and depend on a targeting sequence in the protein, which is recognized by a targeting factor. Once a membrane protein is delivered to the correct organelle its targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6794a9e38d3994784cae063cefe46618
Publikováno v:
The Plant journal : for cell and molecular biology. 70(2)
Auxin is a major growth hormone in plants, and recent studies have elucidated many of the molecular mechanisms underlying its action, including transport, perception and signal transduction. However, major gaps remain in our knowledge of auxin biosyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96b3dee7bd2d6b2bb8f0d656eefa44e0
https://pubmed.ncbi.nlm.nih.gov/22233288
https://pubmed.ncbi.nlm.nih.gov/22233288
Autor:
Verena Kriechbaumer, Susann Lehmann, Rafal Jonczyk, Ottilie von Loeffelholz, Jason C. Young, Richard A. Ewan, Ben M. Abell
Publikováno v:
The Biochemical journal. 438(1)
Chloroplast precursor proteins encoded in the nucleus depend on their targeting sequences for delivery to chloroplasts. There exist different routes to the chloroplast outer envelope, but a common theme is the involvement of molecular chaperones. Hsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99b8004d19164b37a0d1109ca0ad3d9
https://pubmed.ncbi.nlm.nih.gov/21612577
https://pubmed.ncbi.nlm.nih.gov/21612577
Publikováno v:
The Plant journal : for cell and molecular biology. 37(4)
Oleosin protein is targeted to oil bodies via the endoplasmic reticulum (ER) and consists of a lipid-submerged hydrophobic (H) domain that is flanked by cytosolic hydrophilic domains. We investigated the relationship between oleosin ER topology and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::904f1102f0e9e41eee00ba3b7dbb130c
https://pubmed.ncbi.nlm.nih.gov/14756765
https://pubmed.ncbi.nlm.nih.gov/14756765
Autor:
Maurice M. Moloney, Ben M. Abell, Malleva Abenes, Matthew J. Hills, Larry A. Holbrook, Denis J. Murphy
Publikováno v:
The Plant Cell. 9:1481
An Arabidopsis oleosin was used as a model to study oleosin topology and targeting to oil bodies. Oleosin mRNA was in vitro translated with canine microsomes in a range of truncated forms. This allowed proteinase K mapping of the membrane topology. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2005f842a6d2e2246edb10e07e614f36
https://doi.org/10.2307/3870397
https://doi.org/10.2307/3870397