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Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants.

Autor: Denardo A; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Ben Khlifa E; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Bignotti M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Giuliani R; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., D'Acunto E; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Miranda E; Department of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy., Irving JA; UCL Respiratory and the Institute of Structural and Molecular Biology, University College London, London, UK., Fra A; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. annamaria.fra@unibs.it.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Dec 13; Vol. 81 (1), pp. 6. Date of Electronic Publication: 2023 Dec 13.