Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ben K. Johnson"'
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S6 A) In vitro validation of NR0B1 immunofluorescent assay. Data shows images and quantitation of TC32 control cells or TC32 cells following siRNA silencing of NR0B1. B) ki67 and cleaved caspase 3 staining of Ewing sarcoma xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2f345a1354049abb2c9433fb5c3aa
https://doi.org/10.1158/0008-5472.22411779
https://doi.org/10.1158/0008-5472.22411779
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S2 Confocal imaging of TC32 cells treated with 5 nM lurbinectedin for 6 h shows EWS-FLI1 (green) localization. DAPI (blue) staining of the nucleus. C-Terminal FLI1 antibody was used at a concentration of 1:100.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364d07d1a4a1ac213ff9e34efeb07e6c
https://doi.org/10.1158/0008-5472.22411791.v1
https://doi.org/10.1158/0008-5472.22411791.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S5 Mean tumor volume and corresponding mouse weights for cohorts of mice bearing the Ewing sarcoma xenografts TC32 or TC71 as a function of days of treatment with vehicle control (black), lurbinectedin (red), irinotecan (blue) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1e3cc6228bfc91786cf4d6c6bc59d0
https://doi.org/10.1158/0008-5472.22411782.v1
https://doi.org/10.1158/0008-5472.22411782.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
There is a great need to develop novel approaches to target oncogenic transcription factors with small molecules. Ewing sarcoma is emblematic of this need, as it depends on the continued activity of the EWS-FLI1 transcription factor to maintain the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a41e5fed271b51614f576d25c55afa1
https://doi.org/10.1158/0008-5472.c.6508293.v1
https://doi.org/10.1158/0008-5472.c.6508293.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Table S3 Table showing list of EWS-FLI1 targets with corresponding references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8d3f08885189be9bcfca07658f53b4
https://doi.org/10.1158/0008-5472.22411770.v1
https://doi.org/10.1158/0008-5472.22411770.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S4 A) Effect of treatment with 5 nmol/L lurbinectedin for 12 hours on expression of the EWS-FLI1 target genes, BCL11B, LOX, PRKCB and STEAP1. B) Effect of treatment with 10 nmol/L lurbinectedin for 6 or 12 hours on the EWS-FLI1 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74974e6721d5f5357e2cd17cb9a1d8fa
https://doi.org/10.1158/0008-5472.22411785
https://doi.org/10.1158/0008-5472.22411785
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Table S2 EWS-FLI1 gene signature of 116 induced and 50 repressed targets (3,15).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca3df9251bd6b101d36c7192e8aef28
https://doi.org/10.1158/0008-5472.22411773
https://doi.org/10.1158/0008-5472.22411773
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Table S1 Sequences of primers used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007fb54b9acea82545537439c4893036
https://doi.org/10.1158/0008-5472.22411776.v1
https://doi.org/10.1158/0008-5472.22411776.v1
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Supplementary Figure S3 Single-cell imaging of HA-tagged TC32 cells treated with 2.5 nM trabectedin or lurbinectedin for 6 h shows EWS-FLI1 (green) localized into the nucleolus (red). DAPI (blue) staining of the nucleus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4554340bc1b14a2d2aff84709632aa
https://doi.org/10.1158/0008-5472.22411788
https://doi.org/10.1158/0008-5472.22411788
Autor:
Patrick J. Grohar, Pablo M. Aviles, Carlos María Galmarini, Galen Hostetter, Lisa Turner, Mary E. Winn, Maurizio D'Incalci, Megan J. Bowman, Ben K. Johnson, Zachary B. Madaj, Elissa A. Boguslawski, Susan M. Kitchen-Goosen, Matthew K. Easton, Maria Jose Guillen Navarro, Joseph Roland, Nichole Maloney, Matt L. Harlow
Legends for supplementary figures and tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e359a9dfb701c3a54fe1be9986c38d
https://doi.org/10.1158/0008-5472.22411797
https://doi.org/10.1158/0008-5472.22411797