Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen

Autor: Jackie Lighten, Alexander S. T. Papadopulos, Ryan S. Mohammed, Ben J. Ward, Ian G. Paterson, Lyndsey Baillie, Ian R. Bradbury, Andrew P. Hendry, Paul Bentzen, Cock van Oosterhout

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Host-parasite coevolution can lead to arms races favouring novel immunogenetic alleles or the maintenance of diversity in a balanced polymorphism. Here, Lighten et al. combine data on MHC diversity across three guppy species and simulations to show t

Externí odkaz: https://doaj.org/article/db49789d941e4957b4eb89088657f6bb

Adaptive phenotypic response to climate enabled by epigenetics in a K-strategy species, the fish Leucoraja ocellata (Rajidae)

Autor: Jackie Lighten, Danny Incarnato, Ben J. Ward, Cock van Oosterhout, Ian Bradbury, Mark Hanson, Paul Bentzen

Publikováno v: Royal Society Open Science, Vol 3, Iss 10 (2016)

The relative importance of genetic versus epigenetic changes in adaptive evolution is a hotly debated topic, with studies showing that some species appear to be able to adapt rapidly without significant genetic change. Epigenetic mechanisms may be pa

Externí odkaz: https://doaj.org/article/d86ed928d1a84332ae273f50c1faf5e9

Evolutionary genomics of anthroponosis in Cryptosporidium

Autor: Justin A. Pachebat, Cock van Oosterhout, Johanna L. Nader, Guy Robinson, Ben J. Ward, Kevin M. Tyler, Rachel M. Chalmers, Martin T. Swain, Thomas C. Mathers, Paul R. Hunter

Publikováno v: Nature Microbiology. 4:826-836

Human cryptosporidiosis is the leading protozoan cause of diarrhoeal mortality worldwide, and a preponderance of infections is caused by Cryptosporidium hominis and C. parvum. Both species consist of several subtypes with distinct geographical distri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437153ec578e8572c08d369e0c0a9602
https://doi.org/10.1038/s41564-019-0377-x

Pathogen enrichment sequencing (PenSeq) enables population genomic studies in oomycetes

Autor: Ben J. Ward, Katie Baker, Edgar Huitema, Jonathan D. G. Jones, Miles R. Armstrong, Agathe Jouet, Tze-Yin Lim, Paul R. J. Birch, Gaetan Thilliez, Ingo Hein, Cock van Oosterhout

Publikováno v: The New Phytologist

Summary The oomycete pathogens Phytophthora infestans and P. capsici cause significant crop losses world‐wide, threatening food security. In each case, pathogenicity factors, called RXLR effectors, contribute to virulence. Some RXLRs are perceived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505c2639090ce01cf898637249f8f842
http://europepmc.org/articles/PMC6492278

Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

Autor: Kerstin Howe, Thomas M. Keane, Paul Flicek, David Thybert, Bronwen Aken, David Martín-Gálvez, Golbahar Yazdanifar, Christine Feig, Cristina Sisu, Duncan T. Odom, Son Pham, Stefanie Nachtweide, Laura Clarke, Ian Streeter, Carla Cummins, Varshith Chakrapani, Lilue Jingtao, Cock van Oosterhout, Ian T. Fiddes, Alvis Brazma, David J. Adams, William Chow, Frédéric Veyrunes, Maša Roller, Mikhail Kolmogorov, Christina M. Laukaitis, Ambre Aurore Josselin, Matthew Howell, Fergal J. Martin, Klara Stefflova, Benedict Paten, Mario Stanke, Matthieu Muffato, Mark Gerstein, Leo Goodstadt, Fengtang Yang, Michael A. Quail, Anthony G. Doran, Václav Janoušek, Ben J. Ward, Sarah Aldridge, Amonida Zadissa, Fabio C. P. Navarro, Robert C. Karn, Matthew Dunn, Wasiu Akanni

Publikováno v: Genome Research
Genome Research, Cold Spring Harbor Laboratory Press, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩
Genome Research, 2018, 28 (4), pp.448-459. ⟨10.1101/gr.234096.117⟩

Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created chromosome-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fd04d943fa94511f96a605cf6355f
https://www.repository.cam.ac.uk/handle/1810/279898