Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Ben J A Janssen"'
Autor:
Marc van Bilsen, Anneleen Daniels, Olaf Brouwers, Ben J A Janssen, Wouter J A Derks, Agnieszka E Brouns, Chantal Munts, Casper G Schalkwijk, Ger J van der Vusse, Frans A van Nieuwenhoven
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85078 (2014)
BACKGROUND: Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db m
Externí odkaz:
https://doaj.org/article/0971133d3b4e4f369d73c74685f0d613
Autor:
Marina A Aleksinskaya, Ernst E H van Faassen, Jelly Nelissen, Ben J A Janssen, Jo G R De Mey, Roeland Hanemaaijer, Ton Rabelink, Anton Jan van Zonneveld
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57761 (2013)
Nitric oxide (NO) has been implicated in matrix metallopeptidase 9 (MMP9)-dependent mobilization of hematopoietic stem and progenitor cells from bone marrow (BM). However, direct measurement of NO in the BM remained elusive due to its low in situ con
Externí odkaz:
https://doaj.org/article/f5783a14b1194100aa250447e93a484b
Autor:
Bart F J Heijnen, Jelly Nelissen, Helma van Essen, Gregorio E Fazzi, Jan W Cohen Tervaert, Carine J Peutz-Kootstra, John J Mullins, Casper G Schalkwijk, Ben J A Janssen, Harry A J Struijker-Boudier
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57815 (2013)
Transient activation of the renin-angiotensin system (RAS) induces irreversible renal damage causing sustained elevation in blood pressure (BP) in Cyp1a1-Ren2 transgenic rats. In our current study we hypothesized that activation of the AT1-receptor (
Externí odkaz:
https://doaj.org/article/525f71f65d8845759ce3f3b41dd5aaf8
Autor:
Léon J A Spijkers, Rob F P van den Akker, Ben J A Janssen, Jacques J Debets, Jo G R De Mey, Erik S G Stroes, Bert-Jan H van den Born, Dayanjan S Wijesinghe, Charles E Chalfant, Luke MacAleese, Gert B Eijkel, Ron M A Heeren, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21817 (2011)
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is alte
Externí odkaz:
https://doaj.org/article/7ea95473f792457ab3148a3baa0d7cd5
Autor:
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29222 (2011)
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolate
Externí odkaz:
https://doaj.org/article/46004c2b269246d28a6a3d335037f686
Autor:
Merlijn J P M T Meens, Matthijs G Compeer, Tilman M Hackeng, Marc A van Zandvoort, Ben J A Janssen, Jo G R De Mey
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10917 (2010)
BACKGROUND: Endothelin-1 (ET-1), a long-acting paracrine mediator, is implicated in cardiovascular diseases but clinical trials with ET-receptor antagonists were not successful in some areas. We tested whether the quasi-irreversible receptor-binding
Externí odkaz:
https://doaj.org/article/362b3f3584494c208b7774510d6e5d4f
Publikováno v:
British Journal of Pharmacology, 177(8), 1841-1852. Wiley
British Journal of Pharmacology
British Journal of Pharmacology
Background and Purpose The flavonoid quercetin increased the in vitro potency of the alpha(1)-antagonist tamsulosin to reduce phenylephrine-dependent arterial contractions by 10-fold. To examine if this supplement-drug interaction luxates hypotensive
Autor:
Paul M. H. Schiffers, Stephan L. M. Peters, Ben J. A. Janssen, Jo G. R. De Mey, Jelly Nelissen, Léon J. A. Spijkers, Pieter Lemkens, Merlijn J. Meens
Publikováno v:
Hypertension research, 40(8), 738-745. Nature Publishing Group
Hypertension Research, 40(8), 738-745. Nature Publishing Group
Hypertension Research, Vol. 40, No 8 (2017) pp. 738-745
Lemkens, P, Spijkers, L J, Meens, M J, Nelissen, J, Janssen, B, Peters, S L, Schiffers, P M & De Mey, J G 2017, ' Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR ', Hypertension Research, vol. 40, pp. 738-745 . https://doi.org/10.1038/hr.2017.38
Hypertension Research, 40(8), 738-745. Nature Publishing Group
Hypertension Research, Vol. 40, No 8 (2017) pp. 738-745
Lemkens, P, Spijkers, L J, Meens, M J, Nelissen, J, Janssen, B, Peters, S L, Schiffers, P M & De Mey, J G 2017, ' Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR ', Hypertension Research, vol. 40, pp. 738-745 . https://doi.org/10.1038/hr.2017.38
Endothelin 1 (ET-1), a potent vasoconstrictor, pro-mitogenic and pro-inflammatory peptide, may promote development of endothelial dysfunction and arterial remodeling. ET-1 can be formed through cleavage of big-ET-1 by endothelin-converting enzyme (EC
Autor:
Agnieszka Strzelecka, L. H. T. M. Vervoort-Peters, W. Matthijs Blankesteijn, Jacques Debets, Ben J. A. Janssen, Evangelos P. Daskalopoulos, Peter Leenders, Kevin C.M. Hermans
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Frontiers in cardiovascular medicine, 6:118. Frontiers Media S.A.
Frontiers in Cardiovascular Medicine
Frontiers in cardiovascular medicine, 6:118. Frontiers Media S.A.
Frontiers in Cardiovascular Medicine
Introduction: An inadequate wound healing following myocardial infarction (MI) is one of the main etiologies of heart failure (HF) development. Interventions aiming at improving this process may contribute to preserving cardiac function after MI. Our
Autor:
Jaap A. Joles, Daniela Patinha, Maarten P. Koeners, Ben J. A. Janssen, C. T. Paul Krediet, Tonja W. Emans
Publikováno v:
Scientific Reports, 8:16342. Nature Publishing Group
Scientific Reports
Scientific reports, 8(1):16342. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific Reports
Scientific reports, 8(1):16342. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Activation of the renin-angiotensin system may initiate chronic kidney disease. We hypothesised that renal hypoxia is a consequence of hemodynamic changes induced by angiotensin II and occurs prior to development of severe renal damage. Male Sprague-